Oxcarbazepine

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Generic Name: Oxcarbazepine Brand Name(s): Generics only. No brands available.

Uses

What is oxcarbazepine used for?

Oxcarbazepine is commonly used for treating certain types of seizures in patients with epilepsy. It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Oxcarbazepine is an anticonvulsant. It works by slowing abnormal nerve impulses in the brain.

How should I take oxcarbazepine?

Use oxcarbazepine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take oxcarbazepine by mouth with or without food.

It is important to take all doses on time to keep the level of medicine in your blood constant. Take doses at evenly spaced intervals. Do not skip doses.

Taking oxcarbazepine at the same times each day will help you remember to take it.

Continue to take oxcarbazepine even if you feel well. Do not miss any doses. Oxcarbazepine works best when there is a constant level of it in your body.

If oxcarbazepine is stopped, it should be done gradually as directed by your doctor. The risk of seizures may be increased if oxcarbazepine is suddenly stopped.

How do I store oxcarbazepine?

Oxcarbazepine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store oxcarbazepine in the bathroom or the freezer. There may be different brands of oxcarbazepine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush oxcarbazepine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using oxcarbazepine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of oxcarbazepine or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have kidney or liver problems or low blood sodium levels.
  • You have a history of mental or mood problems (e.g., depression), or suicidal thoughts or actions.
  • You have been tested and know whether or not you have a gene type called HLA-B*1502.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using oxcarbazepine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking oxcarbazepine. Oxcarbazepine is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from oxcarbazepine?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Headache
  • Indigestion
  • Mild stomach pain
  • Nausea
  • Tiredness
  • Vomiting

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, eyes, face, lips, or tongue; unusual hoarseness)
  • Blood in the stool
  • Chest pain
  • Decreased coordination
  • Decreased urination
  • Difficulty concentrating or speaking
  • Double vision, changes in vision, or involuntary eye movement
  • Dulled sense of touch; fast, slow, or irregular heartbeat
  • Fever, chills, or sore throat
  • Joint or muscle pain, swelling, or weakness
  • New or worsening mental or mood changes (e.g., depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, behavior changes, suicidal thoughts or actions)
  • New or worsening seizures
  • Nosebleed
  • Severe or persistent stomach pain
  • Shortness of breath
  • Swollen lymph nodes
  • Symptoms of liver problems (e.g., dark urine, loss of appetite, pale stools, yellowing of the skin or eyes)
  • Symptoms of low sodium levels (nausea, general body discomfort, headache, lack of energy, confusion, decreased consciousness, increased frequency or severity of seizures)
  • Tremor
  • Trouble sleeping
  • Trouble walking
  • Uncontrolled muscle movements
  • Unusual bruising or bleeding
  • Unusual tiredness or weakness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with oxcarbazepine?

Oxcarbazepine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with oxcarbazepine?

Oxcarbazepine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with oxcarbazepine?

Oxcarbazepine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using oxcarbazepine.

What is the dose of oxcarbazepine for an adult?

Usual Adult Dose for Epilepsy

Monotherapy:

Initiation of monotherapy:

Immediate-release:

  • Initial dose: 300 mg orally twice a day, increased by increments of 300 mg per day every third day as clinically indicated
  • Maintenance dose: 300 to 1,200 mg orally twice a day
  • Maximum dose: 1,200 mg orally twice a day

Conversion to monotherapy:

Immediate-release:

  • Initial dose: 300 mg orally twice a day, increased by increments of up to 600 mg per day at approximately weekly intervals as clinically indicated
  • Maintenance dose: 300 to 1,200 mg orally twice a day
  • Maximum dose: 1,200 mg orally twice a day

Adjunctive Therapy:

Immediate-release:

  • Initial dose: 300 mg orally twice a day, increased by increments of up to 600 mg per day at approximately weekly intervals as clinically indicated
  • Maintenance dose: 300 mg to 1,200 mg orally twice a day
  • Maximum dose: 1,200 mg orally twice a day

Extended-release:

  • Initial dose: 600 mg orally once a day for one week, increased by increments of 600 mg per day at weekly intervals as clinically indicated
  • Maintenance dose: 1,200 to 2,400 mg orally once a day
  • Maximum dose: 2,400 mg orally once a day

Usual Geriatric Dose for Epilepsy

Extended-release:

Initial dose: 300 to 450 mg orally once a day, increased by increments of 300 to 450 mg per day at weekly intervals as clinically indicated.

What is the dose of oxcarbazepine for a child?

Usual Pediatric Dose for Epilepsy

Monotherapy:

4 to 16 years of age:

Immediate-release:

  • Initiation of monotherapy: 4 to 5 mg/kg orally twice a day (up to 600 mg per day), increased by an increment of 5 mg/kg per day every third day as clinically indicated
  • Conversion to monotherapy: 4 to 5 mg/kg orally twice a day (up to 600 mg per day), increased by an increment of 10 mg/kg per day at approximately weekly intervals as clinically indicated

Maintenance dose:

Body weight:

  • 20 kg: 300 to 450 mg orally twice a day
  • 25 to 30 kg: 450 to 600 mg orally twice a day
  • 35 to 40 kg: 450 to 750 mg orally twice a day
  • 45 kg: 600 to 750 mg orally twice a day
  • 50 to 55 kg: 600 to 900 mg orally twice a day
  • 60 to 65 kg: 600 to 1,050 mg orally twice a day
  • 70 kg: 750 to 1,050 mg orally twice a day

Adjunctive therapy:

2 to 4 years of age:

Immediate-release:

Initial dose:

Body weight:

  • 20 kg or more: 4 to 5 mg/kg orally twice a day (up to 600 mg per day)
  • Less than 20 kg: 8 to 10 mg/kg orally twice a day

Maximum dose: 30 mg/kg orally twice a day

4 to 16 years of age:

Immediate-release:

Initial dose: 4 to 5 mg/kg orally twice a day (up to 600 mg per day)

Maintenance dose:

Body weight:

  • 20 to 29 kg: 900 mg orally per day
  • 1 to 39 kg: 1,200 mg orally per day
  • Greater than 39 kg: 1,800 mg orally per day

6 to 17 years of age:

Extended-release:

Initial dose: 8 to 10 mg/kg (up to 600 mg) orally once a day, increased by an increment of 8 to 10 mg/kg per day (up to 600 mg) at weekly intervals if clinically indicated.

Maintenance dose:

Body weight:

  • 20 to 29 kg: 900 mg orally once a day
  • 1 to 39 kg: 1,200 mg orally once a day
  • Greater than 39 kg: 1,800 mg orally once a day

How is oxcarbazepine available?

Oxcarbazepine is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of oxcarbazepine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: September 2, 2017 | Last Modified: September 2, 2017

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