Oxaprozin

By Medically reviewed by hellodoktor

Generic Name: Oxaprozin Brand Name(s): Generics only. No brands available.

Uses

What is Oxaprozin used for?

Oxaprozin is used to treat arthritis. It reduces pain, swelling, and stiffness of the joints. Oxaprozin is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

How should I take Oxaprozin?

Take this medication by mouth as directed by your doctor, usually once daily. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid.

The dosage is based on your medical condition, body weight, and response to treatment. The manufacturer recommends that adults should not take more than 1,800 milligrams per day or 26 milligrams per kilogram per day, whichever is lower. To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take this drug more often than directed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

In certain conditions (such as arthritis), it may take up to 2 weeks when this drug is taken regularly before you notice the full benefits.

Tell your doctor if your condition worsens.

How do I store Oxaprozin?

Oxaprozin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Oxaprozin in the bathroom or the freezer. There may be different brands of Oxaprozin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Oxaprozin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Oxaprozin?

Before taking oxaprozin, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as history of heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including oxaprozin. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Older adults may be more sensitive to the side effects of this drug, especially stomach bleeding and kidney problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Oxaprozin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Oxaprozin. Oxaprozin is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Oxaprozin?

Upset stomach, constipation, diarrhea, nausea, vomiting, gas, heartburn, drowsiness, dizziness, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: vision changes, hearing changes (such as ringing in the ears), mental/mood changes, persistent/severe headache, unexplained stiff neck, signs of kidney problems (such as change in the amount of urine), easy bruising/bleeding, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Oxaprozin?

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, lithium, methotrexate, “water pills” (diuretics such as furosemide).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac). These drugs are similar to oxaprozin and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Oxaprozin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Oxaprozin?

Oxaprozin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Oxaprozin?

Oxaprozin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Oxaprozin.

What is the dose of Oxaprozin for an adult?

Usual Adult Dose for Osteoarthritis

Loading dose: 1200 mg to 1800 mg orally; not to exceed 26 mg/kg

Maintenance dose: 1200 mg orally once a day

Maximum dose: 1800 mg or 26 mg/kg orally per day, whichever is less, in divided doses

Comments:

-A one-time loading dose may be given if quick onset of action is needed.

-Doses larger than 1200 mg orally per day on a chronic basis are reserved for patients weighing more than 50 kg, with normal renal and hepatic function, at low risk for peptic ulcer, and whose disease severity justifies maximal therapy.

-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient’s treatment goals.

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis

Usual Adult Dose for Rheumatoid Arthritis

Loading dose: 1200 mg to 1800 mg orally; not to exceed 26 mg/kg

Maintenance dose: 1200 mg orally once a day

Maximum dose: 1800 mg or 26 mg/kg orally per day, whichever is less, in divided doses

Comments:

-A one-time loading dose may be given if quick onset of action is needed.

-Doses larger than 1200 mg orally per day on a chronic basis are reserved for patients weighing more than 50 kg, with normal renal and hepatic function, at low risk for peptic ulcer, and whose disease severity justifies maximal therapy.

-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient’s treatment goals.

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis

Renal Dose Adjustments

Severe renal dysfunction (CrCl less than 30 mL/min):

-Initial dose: 600 mg orally once a day

-Maintenance dose: May increase cautiously to 1200 mg with close monitoring if insufficient relief of symptoms

Liver Dose Adjustments

-Patients who have an abnormal liver test or who develop signs or symptoms of liver dysfunction should be evaluated for hepatic dysfunction.

-If liver disease develops or if systemic manifestations such as eosinophilia or rash occur, this drug should be discontinued.

Dose Adjustments

Less than 50 kg:

-Initial dose: 600 mg orally once a day

-Maintenance dose: May increase cautiously to 1200 mg with close monitoring if insufficient relief of symptoms

-Doses larger than 1200 mg orally per day on a chronic basis are reserved for patients weighing more than 50 kg, with normal renal and hepatic function, at low risk for peptic ulcer, and whose disease severity justifies maximal therapy.

Dialysis

-Initial dose: 600 mg orally once a day

-Maintenance dose: May increase cautiously to 1200 mg with close monitoring if insufficient relief of symptoms.

Other Comments

Administration advice:

-Take orally once a day; doses may be divided in patients unable to tolerate single doses.

Storage requirements:

-Protect from light.

-Store at 25C (77F).

General:

-Doses should be individualized to the lowest effective dose for the shortest duration possible to minimize adverse effects.

-Physicians should ensure that patients tolerate doses of 600 mg to 1200 mg orally per day without gastroenterologic, renal, hepatic, or dermatologic adverse effects prior to increasing the dose.

-There is an increased risk of heart attack, heart failure, and stroke when taking nonsteroidal anti-inflammatory drugs (NSAIDs); these events may occur at any time during treatment and risk increases with long term use, a history of cardiovascular (CV) disease or risk factors for CV disease, and higher doses.

Monitoring:

-Cardiovascular: Monitor blood pressure closely during initiation and throughout course of therapy.

-Gastrointestinal: Monitor for signs/symptoms of gastrointestinal bleeding.

-Renal function: Monitor renal status, especially in patients with conditions where renal prostaglandins have a supportive role in the maintenance of renal perfusion.

-Monitor blood counts, renal, and hepatic function periodically for patients receiving long-term therapy.

Patient advice:

-Patients should seek medical advice for signs and symptoms of cardiovascular events, gastrointestinal events, adverse skin reactions, allergic reactions, hepatotoxicity, or unexplained weight gain or edema.

-Patients should seek medical attention immediately if signs/symptoms of cardiovascular events occur, including, shortness of breath, slurred speech, chest pain, or weakness on one side of the body.

-Patients should talk to their health care provider if they are pregnant, planning to become pregnant, or breastfeeding; this drug should not be used during pregnancy at 30 weeks gestation or later.

-Patients should be aware that there are a number of potential drug interactions with this drug and they should speak with a healthcare professional before starting any new medications including over the counter medications.

What is the dose of Oxaprozin for a child?

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis

6 to 16 years:

22 to 31 kg: 600 mg orally once a day

32 to 54 kg: 900 mg orally once a day

55 kg or greater: 1200 mg orally once a day

Maximum dose: 1200 mg orally per day

Comments:

-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient’s treatment goals.

Use: For the relief of signs and symptoms of juvenile rheumatoid arthritis

Usual Pediatric Dose for Osteoarthritis

17 to 18 years:

1200 mg orally once a day

Maximum dose: 1200 mg orally per day

Comment:

-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient’s treatment goals.

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis

Usual Pediatric Dose for Rheumatoid Arthritis

17 to 18 years:

1200 mg orally once a day

Maximum dose: 1200 mg orally per day

Comment:

-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient’s treatment goals.

Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

How is Oxaprozin available?

Oxaprozin is available in the following dosage forms and strengths:

  • Oral tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Oxaprozin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: April 5, 2018 | Last Modified: September 12, 2019

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