By Medically reviewed by hellodoktor

Generic Name: Operoxolid Brand Name(s): Generics only. No brands available.


What is operoxolid (roxithromycin) used for?

Operoxolid is commonly used for the treatment of ear, nose and throat infections, pneumonia (lung infection), skin infections and infections of the genitalia.

How should I take operoxolid (roxithromycin)?

Swallow tablets whole with a full glass of water.

Taking it at the same time each day will have the best effect and will also help you remember when to take it.

Operoxolid should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Operoxolid works best if you take it on an empty stomach.

Continue taking your medicine for as long as your doctor tells you.

For treating infections, operoxolid is usually taken for 5 to 10 days. However, your doctor may prescribe operoxolid for longer periods.

Check with your doctor if you are not sure how long to take this medicine for.

How do I store operoxolid (roxithromycin)?

Operoxolid is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store operoxolid in the bathroom or the freezer. There may be different brands of operoxolid that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush operoxolid down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using operoxolid (roxithromycin)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of operoxolid or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are planning to have surgery or an anesthetic.
  • You are currently receiving or are planning to receive dental treatment.
  • You are hypersensitive to, or have had an allergic reaction to, roxithromycin or any other macrolide antibiotics (e.g., azithromycin, clarithromycin or erythromycin).

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using operoxolid during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking operoxolid.

Side effects

What side effects can occur from operoxolid (roxithromycin)?

Tell your doctor if you notice any of the following:

  • Oral thrush – white, furry, sore tongue and mouth
  • Vaginal thrush – sore and itchy vagina and/or discharge
  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Flatulence
  • Reflex
  • Loss of appetite
  • Red and/or itchy skin
  • Headache
  • Dizziness
  • Deafness/ringing in the ears
  • Hallucinations
  • Confusion
  • Tiredness
  • Altered taste
  • Rash
  • Cough
  • Shortness of breath
  • Wheezing or difficulty breathing
  • Swelling of the face, lips, tongue, or other parts of the body
  • Itching or hives on the skin
  • Fainting
  • Hay fever-like symptoms

Tell your doctor as soon as possible if you notice any of the following, particularly if they occur several weeks after stopping treatment with roxithromycin.

  • Severe abdominal cramps or stomach cramps
  • Watery and severe diarrhea, which may also be bloody
  • Fever, in combination with one or both of the above

These are serious side effects. You may have a serious condition affecting your bowel. You may need urgent medical attention.

  • Upper abdominal pain, which may radiate up to your back
  • Nausea
  • Vomiting (possible symptoms of pancreatitis)
  • Severe persistent diarrhea
  • Progressive skin rash often with blisters or mucosal lesions (e.g. around the eyes, nose, mouth and genitals)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with operoxolid (roxithromycin)?

Operoxolid may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some medicines may interact with roxithromycin, include:

  • Theophylline
  • Ergot alkaloids
  • Disopyramide
  • Terfenadine
  • Astemizole
  • Warfarin
  • Digoxin
  • Midazolam
  • Cyclosporin
  • Cisapride
  • Pimozide
  • Rifabutin and bromocriptine (which use the CYP3A liver enzyme)

Does food or alcohol interact with operoxolid (roxithromycin)?

Operoxolid may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with operoxolid (roxithromycin)?

Operoxolid may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have kidney problems (impaired function) or liver problems (hepatic cirrhosis with jaundice and/or ascites).


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using operoxolid (roxithromycin).

What is the dose of Operoxolid (roxithromycin) for an adult?

The recommended adult dosage is 300 mg per day, which may be taken according to one of the following dosage regimens:

  • One 300 mg tablet once a day
  • One 150 mg tablet twice a day
  • Two 150 mg tablets once a day

However, depending on your condition and how you react to the medicine, your doctor may tell you to take a different dose.

What is the dose of Operoxolid (roxithromycin) for a child?

The dosage of roxithromycin given to children is dependent upon the child’s weight.

The recommended dosage for children weighing 40 kg and over is 300 mg per day, taken according to the following dosage regimen:

  • One 150 mg tablet in the morning and one 150 mg tablet in the evening

This medicine is not recommended for use in children weighing less than 40 kg.

How is Operoxolid (roxithromycin) available?

Operoxolid is available in the following dosage forms and strengths:

  • Operoxolid 150 mg x 1 Blister 10 Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of operoxolid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 20, 2017 | Last Modified: September 12, 2019

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