Generic Name: Opeazitro Brand Name(s): Generics only. No brands available.

Uses

What is Opeazitro® (azithromycin) used for?

Opeazitro® is commonly used for bacterial infections caused by susceptible organisms, such as:

  • Lower respiratory tract infections, e.g., community-acquired pneumonia, bronchitis
  • Upper respiratory tract infections, e.g., pharyngitis, tonsillitis, sinusitis and otitis media
  • Skin and soft tissue infections
  • Uncomplicated genital infections due to Chlamydia trachomatis

How should I take Opeazitro® (azithromycin)?

Opeazitro® is usually given as an injection at your doctor’s office, hospital, or clinic. If you use Opeazitro® at home, a health care provider will teach you how to use it. Be sure you understand how to use Opeazitro®. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Opeazitro® if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Use Opeazitro® on a regular schedule to get the most benefit from it. Using rosampline at the same time each day will help you remember to use it.

To clear up your infection completely, use Opeazitro® for the full course of treatment. Keep using it even if you feel better in a few days.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

How do I store Opeazitro® (azithromycin)?

Opeazitro® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Opeazitro® in the bathroom or the freezer. There may be different brands of Opeazitro® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Opeazitro® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Opeazitro® (azithromycin)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in Opeazitro®.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Since there is a risk of superinfection with non-susceptible bacteria and risk of pseudomembranous colitis while using any broad spectrum antibiotics, caution should be exercised while using azithromycin.

Serious allergic reactions, such as angioedema and anaphylaxis have been reported rarely in patients on azithromycin and other macrolide therapies.

Renal impairment: No dose adjustment is needed in patients with mild renal failure (creatinine clearance > 40 mL/min). However, as no data is available regarding the use of azithromycin in patients with more severe renal impairment, caution should be exercised while using the drug in these patients.

Hepatic impairment: As the hepato-biliary system is the principal route of excretion of azithromycin, it should not be used in patients with hepatic impairment.

Azithromycin is not expected to affect your ability to drive or operate machinery.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Opeazitro® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Opeazitro®.

Side effects

What side effects can occur from Opeazitro® (azithromycin)?

Some side effects may be nausea, vomiting, flatulence diarrhea, skin rash, and pruritus. Occasionally, reversible elevations in liver transaminases can be seen similar to other macrolides.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Opeazitro® (azithromycin)?

Opeazitro® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Antacids reduce the absorption of azithromycin, so when co-administrated it should be taken 1 hour before or 2 hours after the antacid administration.
  • Because of potential interaction between azithromycin and cyclosporin, cyclosporin levels should be monitored and the dose should be adjusted if co-administration is necessary.
  • Some of the macrolide antibiotics are known to decrease the biotransformation of digoxin. Although there is no report regarding such an effect with the use of azithromycin, the possibility of an interaction with concomitant use should be borne in mind and digoxin levels should be monitored.
  • As with other macrolide antibiotics, azithromycin should not be co-administered with ergot derivatives.

Does food or alcohol interact with Opeazitro® (azithromycin)?

Opeazitro® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Opeazitro® (azithromycin)?

Opeazitro® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Opeazitro® (azithromycin).

What is the dose of Opeazitro® (azithromycin) for an adult?

Acute Bacterial Exacerbations of Chronic Obstructive Pulmonary Disease

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Alternatively, the recommended dose is 500 mg PO qDay for 3 days.

Acute Otitis Media

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Genital Ulcer Disease (Chancroid)

The recommended dose is 1 g PO once.

Acute Bacterial Sinusitis

The recommended dose is 500 mg/day PO for 3 days or 2 g PO once.

Community-Acquired Pneumonia

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

The recommended dose is 2 g extended release suspension PO once.

The recommended dose is 500 mg IV as single dose for at least 2 days; follow with oral therapy with single dose of 500 mg to complete 7-10 days course of therapy.

Pharyngitis/Tonsillitis

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Alternatively, the recommended dose is 12 mg/kg PO; not to exceed 500 mg on day 1 followed by 6 mg/kg; not to exceed 250 mg on days 2 through 5.

Uncomplicated Skin/Skin Structure Infections

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Cat Scratch Disease

>45.5 kg: The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Pertussis (Off-label)

The recommended dose is 500 mg PO once, then 250 mg once daily for 4 days.

Acute Pelvic Inflammatory Disease

The recommended dose is 500 mg IV over 1 hour once daily for 1-2 days; follow therapy by oral route with 250 mg qDay for 5 days to complete a 7-day therapy.

Uncomplicated Gonococcal Infections

Infection of pharynx, cervix, urethra, or rectum: Ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days.

Sexual assault

Prophylaxis of sexually transmitted diseases (STDs) such as gonorrhea after sexual assault per CDC guidelines includes the following 3-drug regimen:

  • Ceftriaxone: The recommended dose is 250 mg IM once PLUS.
  • Azithromycin: The recommended dose is 1 g PO once PLUS.
  • Metronidazole or tinidazole: The recommended dose is 2 g PO once.

If alcohol has been recently ingested or emergency contraception is provided, metronidazole or tinidazole can be taken by the victim at home rather than as directly observed therapy to avoid drug interactions.

Mycobacterium Avium Complex Infection

Prevention

  • Primary prophylaxis: The recommended dose is 1.2 g PO once weekly or 600 mg PO twice weekly; with or without rifabutin 300 mg once daily.
  • Secondary prophylaxis: The recommended dose is 500-600 mg PO qDay in combination with ethambutol.

Treatment

  • The recommended dose is 250 mg PO once daily in combination with ethambutol 15 mg/kg/day with or without rifabutin 300 mg/day.
  • Alternative regimen: The recommended dose is 500 mg PO 3 times weekly in combination with ethambutol 15 mg/kg/day with or without rifabutin 300 mg/day.

Endocarditis (Off-label) – Prophylaxis

The recommended dose is 500 mg PO 30-60 min before procedure.

What is the dose of Opeazitro® (azithromycin) for a child?

3-day regimen:

The recommended dose in children is 10 mg/kg as a single daily dose for 3 days. The total dose is 30mg/kg.

Doctors also recommend the single daily dose for 3 days by age and weight as follows:

  • 6 months – 3 years/ 8 – 15kg: the single daily dose is 10mg/kg.
  • 3 – 7 years/ 15 – 25kg: the single daily dose is 200mg.
  • 8 – 11 years/ 26 – 35kg: the single daily dose is 300mg.
  • 12 – 14 years/ 36 – 45kg: the single daily dose is 400mg.

Efficacy and safety information in children under 6 months of age is lacking, so the use of drugs is not recommended in this age group.

5-day regimen:

The recommended dose in children is 10 mg/kg as a single dose on the first day, followed by 5 mg/kg on day 2 through day 5 of the regimen.

How is Opeazitro® (azithromycin) available?

Opeazitro® is available in the following dosage forms and strengths:

  • Box of 6 sachets x 2.5 g oral powder
  • Box of 3 sachets x 2.5 g oral powder
  • Box of 1 blister x 6 film coated caplets
  • Box of 1 blister x 3 film coated caplets

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Opeazitro®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 15, 2017 | Last Modified: April 15, 2017

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