Onkovertin

By Medically reviewed by hellodoktor

Generic Name: Onkovertin Brand Name(s): Onkovertin and Onkovertin.

Uses

What is onkovertin (dextran 40, sodium chloride) used for?

Onkovertin is commonly used for plasma substitute in surgery, trauma, shocks, burns, and hemorrhage.

How should I take onkovertin (dextran 40, sodium chloride)?

This drug is injected through IV infusion by your doctor.

How do I store onkovertin (dextran 40, sodium chloride)?        

Onkovertin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store onkovertin in the bathroom or the freezer. There may be different brands of onkovertin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush onkovertin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Dextran flakes may form in solution when stored for long periods or if storage temperature varies greatly. Dissolve flakes by heating solution in a water bath at 100°C until clear, or by autoclaving at 110°C for 15 minutes.

Precautions & warnings

What should I know before using onkovertin (dextran 40, sodium chloride)?

Infusion rate is dependent on patient-specific requirements (e.g., amount of fluid loss, resultant hemoconcentration). May infuse the first 500 mL (10 mL/kg) of solution rapidly if closely monitoring central venous pressure; however, infuse the remainder of the dose slowly.

If not monitoring central venous pressure, infuse drug more slowly; closely observe patient for signs of circulatory overload.

This drug is contraindicated in case of:

  • Severe CHF or cardiac decompensation
  • Thrombocytopenia
  • Renal failure with anuria or severe oliguria

Also, there are some warnings that you may notice:

  • Impaired renal function
  • Clotting defects, polycythemia, hemorrhage
  • Chronic liver disease or hypovolemia
  • Correct deficiency of coagulation factors before use
  • Maintain fluid and electrolyte balance

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using onkovertin during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking onkovertin.

Side effects

What side effects can occur from onkovertin (dextran 40, sodium chloride)?

Some side effects may occur when using this drug, including:

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with onkovertin (dextran 40, sodium chloride)?

Onkovertin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Aminoglycosides
  • Anticoagulants

Does food or alcohol interact with onkovertin (dextran 40, sodium chloride)?

Onkovertin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with onkovertin (dextran 40, sodium chloride)?

Onkovertin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using onkovertin (dextran 40, sodium chloride).

What is the dose of Onkovertin (dextran 40, sodium chloride) for an adult?

Shock

Adjust dosage and rate of infusion based on individual patient requirements, amount of fluid loss, and resultant hemoconcentration.

Maximum total dosage (first 24 hours) is 2 g/kg (20 mL/kg); thereafter, maximum dosage of 1 g/kg (10 mL/kg) daily for up to 5 days.

Extracorporeal Circulation

Usual dose is 1–2 g/kg (10–20 mL/kg).

Maximum dose is 2 g/kg (20 mL/kg).

The amount of solution used varies with the volume of the pump oxygenator.

Prophylaxis of Thromboembolic Disorders

Select dosage according to the risk of thromboembolic complications (e.g., type of surgery, duration of immobilization).

Generally, the day of surgery, 50–100 g (500–1000 mL [approximately 10 mL/kg]). Then, 50 g (500 mL) daily for an additional 2–3 days. Thereafter, may give 50 g (500 mL) every 2–3 days for up to 2 weeks, according to the risk of thromboembolic complications.

What is the dose of Onkovertin (dextran 40, sodium chloride) for a child?

Shock

Adjust dosage and rate of infusion based on individual patient requirements, amount of fluid loss and resultant hemoconcentration.

Infants: the recommended dose is 0.5 g/kg (5 mL/kg).

Children: the recommended dose is 1 g/kg (10 mL/kg).

Adolescents: Maximum total dosage (first 24 hours) is 2 g/kg (20 mL/kg); thereafter, maximum dosage is 1 g/kg (10 mL/kg) daily for up to 5 days.

Extracorporeal Circulation

Infants: the recommended dose is 0.5 g/kg (5 mL/kg).

Children: the recommended dose is 1 g/kg (10 mL/kg).

Prophylaxis of Thromboembolic Disorders

Infants: the recommended dose is 0.5 g/kg (5 mL/kg).

Children: the recommended dose is 1 g/kg (10 mL/kg).

Adolescents: Select dosage according to the risk of thromboembolic complications (e.g., type of surgery, duration of immobilization). Generally, the day of surgery, 50–100 g (500–1000 mL [approximately 10 mL/kg]). Then, 50 g (500 mL) daily for an additional 2–3 days. Thereafter, may give 50 g (500 mL) every 2–3 days for up to 2 weeks, according to the risk of thromboembolic complications.

How is Onkovertin (dextran 40, sodium chloride) available?

Onkovertin is available in the following dosage forms and strengths:

  • Onkovertin injection solution Dextran 40 in NaCl 0.9% 500ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of onkovertin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 15, 2017 | Last Modified: September 12, 2019

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