What is omeprazole?

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Generic Name: Omeprazole Brand Name(s): Generics only. No brands available.

Know the basics

What is omeprazole used for?

Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Omeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

If you are self-treating with this medication, over-the-counter omeprazole products are used to treat frequent heartburn (occurring 2 or more days a week). Since it may take 1 to 4 days to have full effect, these products do not relieve heartburn right away.

For over-the-counter products, carefully read the package instructions to make sure the product is right for you. Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar brand names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

How should I take omeprazole?

Read the Patient Information Leaflet if available from your pharmacist before you start taking omeprazole and each time you get a refill.

Take this medication by mouth as directed by your doctor, usually once daily, before a meal. If you are self-treating, follow all directions on the product package. Dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on weight. Do not increase your dose or take this drug more often than directed. If you have any questions, ask your doctor or pharmacist.

Do not crush, break, or chew the tablets. Swallow this medication whole with a glass of water.

If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take omeprazole at least 30 minutes before sucralfate.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better. If you are self-treating with the over-the-counter product, do not take it for more than 14 days unless directed by your doctor.

Tell your doctor if your condition persists or worsens. If you are self-treating, tell your doctor if your heartburn persists after 14 days or if you need to use this medication more than once every 4 months. If you think you may have a serious medical problem, get medical help right away.

How do I store omeprazole?

Omeprazole is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store omeprazole in the bathroom or the freezer. There may be different brands of omeprazole that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush omeprazole down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using omeprazole?

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of omeprazole in children 1 to 16 years of age. Safety and efficacy have not been established in children younger than 1 year of age. .

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of omeprazole in the elderly.

Is it safe to take omeprazole during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Know the side effects

What are the side effects of omeprazole?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody; or
  • low magnesium (dizziness, confusion, fast or uneven heart rate, jerking muscle movements, jittery feeling, muscle cramps, muscle weakness or limp feeling, cough or choking feeling, seizure).

Common side effects may include:

  • fever;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • stomach pain, gas;
  • nausea, vomiting, mild diarrhea; or
  • headac

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with omeprazole?

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atazanavir
  • Bendamustine
  • Bosutinib
  • Citalopram
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Dabrafenib
  • Dasatinib
  • Delavirdine
  • Erlotinib
  • Eslicarbazepine Acetate
  • Indinavir
  • Ketoconazole
  • Ledipasvir
  • Methotrexate
  • Mycophenolate Mofetil
  • Nelfinavir
  • Nilotinib
  • Pazopanib
  • Saquinavir
  • Tacrolimus
  • Topotecan
  • Vismodegib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Armodafinil
  • Carbamazepine
  • Cilostazol
  • Cranberry
  • Digoxin
  • Disulfiram
  • Fluconazole
  • Ginkgo Biloba
  • Iron
  • Levothyroxine
  • Raltegravir
  • St John’s Wort
  • Tipranavir
  • Triazolam
  • Voriconazole
  • Warfarin

Does food or alcohol interact with omeprazole?

Omeprazole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with omeprazole?

Omeprazole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Diarrhea or
  • Hypomagnesemia (low magnesium in the blood), history of or
  • Osteoporosis (bone problem) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of omeprazole for an adult?

Usual Adult Dose for Duodenal Ulcer:

20 mg orally once a day before a meal. Most patients heal within 4 to 8 weeks.

Usual Adult Dose for Gastric Ulcer:

40 mg orally once a day before a meal for 4 to 8 weeks.

Usual Adult Dose for Erosive Esophagitis:

20 mg orally once a day before a meal. This dosage may be increased to 40 mg per day based on desired clinical response and patient tolerance. Studies have been completed up to 12 months for maintenance therapy of erosive esophagitis.

Usual Adult Dose for Zollinger-Ellison Syndrome:

Initial: 60 mg orally once a day. Dosage should be individualized to patient’s needs.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Gastroesophageal Reflux Disease:

Initial: 20 mg orally once a day before a meal for 4 to 8 weeks. This dosage may be increased to 40 mg per day if needed.

Maintenance: long-term treatment with doses of 10 to 20 mg per day may be required for maintenance therapy of refractory disease and appears to be safe.

Usual Adult Dose for Multiple Endocrine Adenomas:

Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Systemic Mastocytosis:

Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Dyspepsia:

Prevention of frequent heartburn: 20 mg orally once daily, before a meal, for 14 days.

What is the dose of omeprazole for a child?

Usual Pediatric Dose for Erosive Esophagitis:

Oral:

Infants:

GERD: 0.7 mg/kg/dose once daily reduced the percentage of time gastric and esophageal pH less than 4, as well as the number of reflux episodes in 10 neonates [mean PMA: 36.1 weeks, (34 to 40 weeks)] in a trial. Higher doses of 1 to 1.5 mg/kg/day have been reported

Children and Adolescents 1 to 16 years:

GERD, ulcers, esophagitis:

Manufacturer recommendations:

5 kg to less than 10 kg: 5 mg once daily

10 kg to less than or equal to 20 kg: 10 mg once daily

Greater than 20 kg: 20 mg once daily

Alternate dosing:

Children 1 to 16 years:

1 mg/kg/dose once or twice daily

Adjunctive therapy of duodenal ulcers associated with Helicobacter pylori (in combination with antibiotic therapy either clarithromycin or clarithromycin and amoxicillin) in children:

15 to 30 kg: 10 mg twice daily

Greater than 30 kg: 20 mg twice daily

Comment: The safety and efficacy of omeprazole use in patients less than 1 year of age and for pediatric uses other than the treatment of GERD and maintenance of healing of erosive esophagitis has not been established.

Usual Pediatric Dose for Gastroesophageal Reflux Disease:

Oral:

Infants:

GERD: 0.7 mg/kg/dose once daily reduced the percentage of time gastric and esophageal pH less than 4, as well as the number of reflux episodes in 10 neonates [mean PMA: 36.1 weeks, (34 to 40 weeks)] in a trial. Higher doses of 1 to 1.5 mg/kg/day have been reported

Children and Adolescents 1 to 16 years:

GERD, ulcers, esophagitis:

Manufacturer recommendations:

5 kg to less than 10 kg: 5 mg once daily

10 kg to less than or equal to 20 kg: 10 mg once daily

Greater than 20 kg: 20 mg once daily

Alternate dosing:

Children 1 to 16 years:

1 mg/kg/dose once or twice daily

Adjunctive therapy of duodenal ulcers associated with Helicobacter pylori (in combination with antibiotic therapy either clarithromycin or clarithromycin and amoxicillin) in children:

15 to 30 kg: 10 mg twice daily

Greater than 30 kg: 20 mg twice daily

How is omeprazole available?

Omeprazole is available in the following dosage forms and strengths:

Capsule 10 mg; 20 mg; 40 mg

Suspension 2,5 mg; 10 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdose may include the following:

  • confusion
  • drowsiness
  • blurred vision
  • fast or pounding heartbeat
  • nausea
  • vomiting
  • sweating
  • flushing (feeling of warmth)
  • headache
  • dry mouth

What should I do if I miss a dose?

If you miss a dose of omeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: May 30, 2016 | Last Modified: January 4, 2017

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