Ofloxacin

By Medically reviewed by hellodoktor

Generic Name: Ofloxacin Brand Name(s): Generics only. No brands available.

Uses

What is Ofloxacin used for?

Ofloxacin is used to treat a variety of bacterial infections. Ofloxacin belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

How should I take Ofloxacin?

Take this medication by mouth with or without food as directed by your doctor, usually twice a day (every 12 hours). The dosage and length of treatment is based on your medical condition and response to treatment.

Drink plenty of fluids while taking this medication unless your doctor tells you otherwise.

Take this medication at least 2 hours before or 2 hours after taking other products that may bind to it, decreasing its effectiveness. Ask your pharmacist about the other products you take. Some examples include: quinapril, sucralfate, vitamins/minerals (including iron and zinc supplements), and products containing magnesium, aluminum, or calcium (such as antacids, didanosine solution, calcium supplements).

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

How do I store Ofloxacin?

Ofloxacin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Ofloxacin in the bathroom or the freezer. There may be different brands of Ofloxacin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Ofloxacin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Ofloxacin?

Before taking ofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (such as ciprofloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizure disorder, conditions that increase your risk of seizures (such as brain/head injury, brain tumors), nerve problems (such as peripheral neuropathy), kidney disease, liver disease, mental/mood disorders (such as depression), myasthenia gravis, joint/tendon problems (such as tendonitis, bursitis).

Ofloxacin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ofloxacin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using ofloxacin safely.

This medication may rarely cause serious changes in blood sugar, especially if you have diabetes. Check your blood sugar regularly as directed and share the results with your doctor. Watch for symptoms of high blood sugar, such as increased thirst/urination. Also watch for symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or by drinking fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Your doctor may need to switch you to another antibiotic or adjust your diabetes medications if any reaction occurs.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Ofloxacin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be more sensitive to the side effects of this drug, especially joint/tendon problems.

Older adults may be more sensitive to the side effects of this drug, such as tendon problems (especially if they are also taking corticosteroids such as prednisone or hydrocortisone) and QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Ofloxacin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Ofloxacin. Ofloxacin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Ofloxacin?

Upset stomach, nausea, diarrhea, headache, dizziness, lightheadedness, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, signs of a new infection (such as new/persistent fever, persistent sore throat), signs of kidney problems (such as change in the amount of urine), signs of liver problems (such as unusual tiredness, stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine).

Get medical help right away if you have any very serious side effects, including: hearing changes, unsteadiness, severe dizziness, fainting, fast/irregular heartbeat.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Ofloxacin?

Some products that may interact with this drug include: “blood thinners” (such as acenocoumarol, warfarin), strontium.

Many drugs besides ofloxacin may affect the heart rhythm (QT prolongation), including dofetilide, procainamide, amiodarone, quinidine, sotalol, among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

Ofloxacin is very similar to levofloxacin. Do not use medications containing levofloxacin while using ofloxacin.

This medication may interfere with certain laboratory tests (such as urine screening for opiates), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Ofloxacin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Ofloxacin?

Ofloxacin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Ofloxacin?

Ofloxacin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Ofloxacin.

What is the dose of Ofloxacin for an adult?

Usual Adult Dose for Bronchitis

400 mg orally every 12 hours for 10 days

Comments:

-Since fluoroquinolones (including this drug) have been associated with serious side effects and acute bacterial exacerbations of chronic bronchitis (ABECB) is self-limiting for some patients, this drug should be saved for treatment of ABECB in patients with no alternative treatment options.

Use: For the treatment of ABECB due to Haemophilus influenzae or Streptococcus pneumoniae

Usual Adult Dose for Pneumonia

400 mg orally every 12 hours for 10 days

Uses: For the treatment of community-acquired pneumonia due to H influenzae or S pneumoniae; for the treatment of uncomplicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, S pyogenes, or Proteus mirabilis

Usual Adult Dose for Skin and Structure Infection

400 mg orally every 12 hours for 10 days

Uses: For the treatment of community-acquired pneumonia due to H influenzae or S pneumoniae; for the treatment of uncomplicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, S pyogenes, or Proteus mirabilis

Usual Adult Dose for Gonococcal Infection – Uncomplicated

400 mg orally once

Uses: For the treatment of acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae

US CDC recommendations:

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.

-Antimicrobial susceptibility patterns should be monitored.

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Nongonococcal Urethritis

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:

-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.

-Antimicrobial susceptibility patterns should be monitored.

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Chlamydia Infection

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:

-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.

-Antimicrobial susceptibility patterns should be monitored.

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Cervicitis

300 mg orally every 12 hours for 7 days

Uses: For the treatment of nongonococcal cervicitis and urethritis due to Chlamydia trachomatis; for the treatment of mixed infection of the cervix and urethra due to C trachomatis and N gonorrhoeae

US CDC recommendations: 300 mg orally twice a day for 7 days

Comments:

-Recommended as an alternative regimen for nongonococcal urethritis and for chlamydial infection

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; dual therapy with ceftriaxone and azithromycin is the recommended regimen for treatment of gonorrhea in the US.

-Antimicrobial susceptibility patterns should be monitored.

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Pelvic Inflammatory Disease

400 mg orally every 12 hours for 10 to 14 days

Comments:

-If suspect infecting pathogens include anaerobic microorganisms, appropriate treatment for anaerobic pathogens should be used.

Use: For the treatment of acute pelvic inflammatory disease (including severe infection) due to C trachomatis and/or N gonorrhoeae

US CDC recommendations: 400 mg orally twice a day for 14 days

Comments:

-Recommended as an alternative agent for mild to moderately severe acute pelvic inflammatory disease (PID)

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; as a result, regimens that include a quinolone are not recommended for the treatment of PID.

-If parenteral cephalosporin therapy is not possible, use of this drug (with oral metronidazole) can be considered if community prevalence and individual risk for gonorrhea are low.

-Prior to therapy, diagnostic tests for gonorrhea must be performed; if test results are positive for quinolone-resistant N gonorrhoeae and cephalosporin therapy is not possible, an infectious-disease specialist should be consulted.

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Cystitis

200 mg orally every 12 hours

Duration of therapy:

-For infections due to Escherichia coli or Klebsiella pneumoniae: 3 days

-For infections due to other organisms: 7 days

Comments:

-Since fluoroquinolones (including this drug) have been associated with serious side effects and uncomplicated cystitis is self-limiting for some patients, this drug should be saved for treatment of uncomplicated cystitis in patients with no alternative treatment options.

Use: For the treatment of uncomplicated cystitis due to Citrobacter diversus, Enterobacter aerogenes, E coli, K pneumoniae, P mirabilis, or Pseudomonas aeruginosa

Usual Adult Dose for Urinary Tract Infection

200 mg orally every 12 hours for 10 days

Use: For the treatment of complicated urinary tract infections due to E coli, K pneumoniae, P mirabilis, C diversus, or P aeruginosa

Usual Adult Dose for Prostatitis

300 mg orally every 12 hours for 6 weeks

Use: For the treatment of prostatitis due to E coli

Usual Adult Dose for Epididymitis – Non-Specific

US CDC recommendations: 300 mg orally twice a day for 10 days

Comments:

-A recommended regimen for acute epididymitis most likely due to enteric organisms

-With ceftriaxone, a recommended regimen for acute epididymitis most likely due to sexually-transmitted chlamydia and gonorrhea and enteric organisms (men practicing insertive anal sex)

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; use of this drug should be considered if infection is most likely due to enteric organisms and tests have ruled out gonorrhea.

-All patients should be tested for other sexually-transmitted infections (including HIV).

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Epididymitis – Sexually Transmitted

US CDC recommendations: 300 mg orally twice a day for 10 days

Comments:

-A recommended regimen for acute epididymitis most likely due to enteric organisms

-With ceftriaxone, a recommended regimen for acute epididymitis most likely due to sexually-transmitted chlamydia and gonorrhea and enteric organisms (men practicing insertive anal sex)

-Due to high rates of resistance, fluoroquinolones are not recommended for treatment of gonococcal infections in the US; use of this drug should be considered if infection is most likely due to enteric organisms and tests have ruled out gonorrhea.

-All patients should be tested for other sexually-transmitted infections (including HIV).

-The patient’s sexual partner(s) should also be evaluated/treated.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Pyelonephritis

Some experts recommend: 200 to 400 mg orally every 12 hours for 7 to 14 days

Comments:

-Recommended as empiric therapy in uncomplicated acute pyelonephritis

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Shigellosis

Infectious Diseases Society of America (IDSA) recommendations: 300 mg orally twice a day

Duration of Therapy:

-Immunocompetent patients: 3 days

-Immunocompromised patients: 7 to 10 days (Shigella species); 3 days (other listed pathogens)

Comments:

-Recommended for Shigella species, E coli species (enterotoxigenic, enteropathogenic, enteroinvasive), Aeromonas, Plesiomonas

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Infectious Diarrhea

Infectious Diseases Society of America (IDSA) recommendations: 300 mg orally twice a day

Duration of Therapy:

-Immunocompetent patients: 3 days

-Immunocompromised patients: 7 to 10 days (Shigella species); 3 days (other listed pathogens)

Comments:

-Recommended for Shigella species, E coli species (enterotoxigenic, enteropathogenic, enteroinvasive), Aeromonas, Plesiomonas

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Salmonella Enteric Fever

IDSA recommendations: 300 mg orally twice a day

Duration of Therapy:

-Immunocompetent patients: 5 to 7 days

-Immunocompromised patients: 14 days (or longer if relapsing)

Comments:

-Recommended for non-typhi species of Salmonella if severe, patient is older than 50 years, or patient has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Salmonella Gastroenteritis

IDSA recommendations: 300 mg orally twice a day

Duration of Therapy:

-Immunocompetent patients: 5 to 7 days

-Immunocompromised patients: 14 days (or longer if relapsing)

Comments:

-Recommended for non-typhi species of Salmonella if severe, patient is older than 50 years, or patient has prostheses, valvular heart disease, severe atherosclerosis, malignancy, or uremia

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Traveler’s Diarrhea

IDSA recommendations: 200 mg orally twice a day

Duration of therapy: 24 hours to 3 days

Comments:

-Travelers should be provided with 3 days of treatment and should be advised to reevaluate themselves 24 hours after starting therapy; if not completely well at 24 hours, patients should be advised to continue therapy until well or until they have completed the 3-day regimen.

-Current guidelines should be consulted for additional information.

Renal Dose Adjustments

CrCl 20 to 50 mL/min: After a normal initial dose, the usual recommended dose every 24 hours

CrCl less than 20 mL/min: After a normal initial dose, one-half the usual recommended dose every 24 hours

Comments:

-This drug should be used with caution in patients with renal dysfunction.

-Careful clinical monitoring and appropriate laboratory studies recommended before and during therapy.

Liver Dose Adjustments

Severe liver dysfunction (e.g., cirrhosis with or without ascites): Maximum dose should not exceed 400 mg/day.

Comments:

-This drug should be used with caution in patients with liver dysfunction.

-Careful clinical monitoring and appropriate laboratory studies recommended before and during therapy.

Other Comments

Administration advice:

-May administer without regard to food

-Administer this drug at least 2 hours before or 2 hours after iron-, zinc-, calcium-, aluminum-, or magnesium-containing products (e.g., antacids, sucralfate, mineral supplements/multivitamins, buffered didanosine).

-Maintain adequate hydration of patients to prevent formation of highly-concentrated urine.

Storage requirements:

-Store at 20C to 25C (68F to 77F) in well-closed container.

General:

-This drug is indicated for the treatment of adults with mild to moderate infections (unless otherwise indicated) due to susceptible strains of the designated bacteria.

-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

-Appropriate culture and susceptibility testing recommended before therapy to isolate and identify infecting organisms and to establish susceptibility to this drug. Therapy may be started before test results are known; appropriate therapy should be continued when results are available.

-Some strains of P aeruginosa may develop resistance relatively quickly during therapy.

Monitoring:

-Hematologic: Organ system functions, including hematopoietic (periodically during prolonged therapy)

-Hepatic: Organ system functions, including hepatic (periodically during prolonged therapy)

-Infections/Infestations: Culture and susceptibility (periodically during therapy)

-Metabolic: Blood glucose in diabetics

-Renal: Organ system functions, including renal (periodically during prolonged therapy)

Patient advice:

-Read the US FDA-approved Medication Guide.

-Drink plenty of fluids.

-Avoid missing doses and complete the entire course of therapy.

-Avoid or minimize exposure to natural or artificial sunlight; use sun protection (e.g., protective clothing, sunscreen) if sun exposure cannot be avoided. Contact physician if sunburn-like reaction or skin eruption develops.

-Do not drive, operate machinery, or engage in other tasks that require mental alertness or coordination until you know how the drug affects you.

-Stop this drug immediately and contact healthcare provider if a serious side effect occurs.

-Stop this drug and contact healthcare provider if tendon pain, swelling, or inflammation develops or you have weakness or are unable to use 1 of your joints; rest and do not exercise.

-Stop this drug at once and contact physician if symptoms of peripheral neuropathy develop.

-Contact physician immediately if any muscle weakness worsens or respiratory problems develop or if watery and bloody stools occur; contact physician if persistent headache (with or without blurred vision) or signs/symptoms of liver injury occur.

-Stop this drug immediately at first sign of rash or other symptoms of allergic reaction.

What is the dose of Ofloxacin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Ofloxacin available?

Ofloxacin is available in the following dosage forms and strengths:

  • Oral tablet,
  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Ofloxacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: April 5, 2018 | Last Modified: September 12, 2019

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