Nuril

By Medically reviewed by hellodoktor

Generic Name: Nuril Brand Name(s): Nuril.

Uses

What is Nuril® (enalapril) used for?

Nuril® is commonly used for treating high blood pressure (hypertension) in adults and children who are at least 1 month old; congestive heart failure in adults and disorder of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart).

How should I take Nuril® (enalapril)?

To take Nuril®,

  • Take Nuril® with or without food.
  • Dose adjustment is required for better results.
  • Do not take this medication longer than recommended.

How do I store Nuril® (enalapril)?

Nuril® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Nuril® in the bathroom or the freezer. There may be different brands of Nuril® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Nuril® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Nuril® (enalapril)?

You should not use Nuril® if:

  • You are allergic to ingredients of Nuril®.
  • You have a history of angioedema.
  • You are allergic to any other ACE inhibitor, such as benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.
  • You have diabetes. Do not use Nuril® together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).
  • You have kidney disease.

Is it safe during pregnancy or breastfeeding?

Pregnancy

There are no adequate studies in women for determining risk when using Nuril® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Nuril®. Nuril® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Breastfeeding

Nuril® can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using this medicine.

Side effects

What side effects can occur from Nuril® (enalapril)?

The common side effects when using this drug including:

  • Dizziness
  • Tired feeling
  • Cough
  • Feeling light-headed

If you have some symptoms below, call your doctor at once:

  • Feeling light-headed
  • Feeling pass out
  • Pounding heartbeats or fluttering in your chest
  • High potassium – slow heart rate
  • Weak pulse
  • Muscle weakness
  • Tingly feeling
  • Low white blood cell counts – sudden weakness or ill feeling
  • Fever
  • Chills
  • Painful mouth sores
  • Pain when swallowing
  • Skin sores
  • Cold or flu symptoms
  • Cough
  • Trouble breathing
  • Signs of a kidney problem – little or no urinating, painful or difficult urination
  • Swelling in your feet or ankles
  • Feeling tired or short of breath

Get emergency medical help if you have any of these signs of an allergic reaction:

  • Hives
  • Severe stomach pain
  • Difficult breathing
  • Swelling of your face, lips, tongue, or throat

Interactions

What drugs may interact with Nuril® (enalapril)?

Nuril® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • Aliskiren
  • Everolimus or sirolimus
  • Lithium
  • ARBs including losartan/valsartan, birth control pills containing drospirenone
  • Sacubitril

Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure or worsen your heart failure. Ask your pharmacist for more details.

Does food or alcohol interact with Nuril® (enalapril)?

Nuril® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Nuril® (enalapril)

Nuril® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure Nuril® is safe for you, tell your doctor if you have:

  • Kidney disease
  • Liver disease
  • A history of blood clot or stroke
  • An electrolyte imbalance (such as high levels of potassium in your blood)
  • Heart disease or congestive heart failure

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Nuril® (enalapril).

What is the dose of Nuril® (enalapril) for an adult?

Usual adult dose for hypertension:

Initial dose (oral tablets or solution): 5 mg orally once a day.

Maintenance dose (oral tablets or solution): 10 to 40 mg orally per day as a single dose or in 2 divided doses.

Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses.

In combination with diuretics:

Initial dose: 2.5 mg orally once a day.

If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with Nuril® (2.5 mg).

If required, diuretic therapy may be gradually resumed.

Parenteral: 1.25 to 5 mg IV over a 5-minute period every 6 hours.

Comments:

  • Clinical response is usually seen within 15 minutes after IV administration.
  • If required, diuretic therapy may be gradually resumed.

Usual adult dose for congestive heart failure:

Initial dose: 2.5 mg orally once a day.

Maintenance dose: 2.5 to 20 mg daily in 2 divided doses.

Maximum dose: 40 mg orally per day in 2 divided doses.

Comments:

  • Treatment is usually combined with diuretics and digitalis.
  • Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual adult dose for left ventricular dysfunction:

Initial dose: 2.5 mg orally twice a day.

Maintenance dose: 20 mg orally per day in 2 divided doses.

Comments:

  • After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour.
  • If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

What is the dose of Nuril® (enalapril) for a child?

Usual pediatric dose for hypertension:

Children 1 month to 17 years (oral tablets or solution)

  • Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response.
  • Maximum dose: doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients.

Comment:

  • Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 ml/min, as no data are available.

How is Nuril® (enalapril) available?

Nuril® is available in the following dosage forms and strengths:

  • Nuril® tablet 2.5mg
  • Nuril® tablet 5mg
  • Nuril® tablet 10mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Nuril®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: December 26, 2016 | Last Modified: September 13, 2019

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