Generic Name: Novocain Brand Name(s): Generics only. No brands available.


What is Novocain® (procaine) used for?

Novocain® is a local anesthetic. Procaine causes loss of feeling (numbness) of skin and mucous membranes.

Novocain® is used as an injection during surgery and other medical and dental procedures.

Novocain® may also be used for purposes other than those listed here.

How should I take Novocain® (procaine)?

Your healthcare provider will administer procaine as an injection.

How do I store Novocain® (procaine)?

Novocain® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Novocain® in the bathroom or the freezer. There may be different brands of Novocain® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Novocain® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Novocain® (procaine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Novocain® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Before using Novocain®, talk to your healthcare provider if you have

  • Liver problems
  • Bleeding or blood clotting problems
  • Heart problems
  • A neuromuscular disease such as myasthenia gravis
  • Other serious medical conditions

You may not be able to use procaine, or you may require a dosage adjustment or special monitoring during treatment.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Novocain® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Novocain®. Novocain® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Novocain® (procaine)?

Stop using procaine and seek emergency medical attention or contact your doctor immediately if you experience any of the following rare but serious side effects:

  • An allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • Chest pain or slow or irregular heartbeats
  • Dizziness or drowsiness
  • Anxiety or restlessness
  • Nausea or vomiting
  • Trembling, shaking, or seizures (convulsions)

Other less serious side effects such as numbness, tingling, or minor pain at or around the injection site are more likely to occur. Contact your healthcare provider if these effects seem excessive or prolonged.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Novocain® (procaine)?

Novocain® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Warfarin (Coumadin)
  • A monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate)
  • Mecamylamine (Inversine)
  • Guanadrel (Hylorel) or guanethidine (Ismelin)
  • A medicine to treat high blood pressure
  • A medicine to improve muscle strength or tone for conditions such as myasthenia gravis

Does food or alcohol interact with Novocain® (procaine)?

Novocain® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Novocain® (procaine)?

Novocain® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Novocain® (procaine).

What is the dose of Novocain® (procaine) for an adult?

As with all local anesthetics, the dose of Novocain® varies and depends upon the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, individual tolerance, and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.

What is the dose of Novocain® (procaine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Novocain® (procaine) available?

Novocain® is available in the following dosage forms and strengths:

  • Injection, USP: procaine hydrochloride

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Novocain®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia


Review Date: August 28, 2017 | Last Modified: September 3, 2017

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