Generic Name: Nicotinamide Brand Name(s): Generics only. No brands available.


What is nicotinamide used for?

Nicotinamide is a vitamin (B3), used to increase the “good” cholesterol (High Density Lipoprotein, HDL) level and decrease triglyceride levels in your blood.

How should I take nicotinamide?

For orally taken form, you should:

  • Take nicotinamide by mouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using nicotinamide.
  • Consult your doctor for any information on the label that you do not clearly understand.
  • It is best to take this medicine after your last meal of the day.
  • Swallow the extended­-release tablet whole. Do not crush, break, or chew it.

How do I store nicotinamide?

Nicotinamide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store nicotinamide in the bathroom or the freezer. There may be different brands of nicotinamide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush nicotinamide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using nicotinamide?

Before using nicotinamide, tell your doctor if you have:

  • Allergic reaction: to nicotinamide, excipients using for dosage form containing nicotinamide. The information is detailed in the leaflet.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Pediatric.
  • Geriatric.
  • Used any other health conditions, drugs that have a risk of interaction with nicotinamide.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using nicotinamide during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking nicotinamide.

Side effects

What side effects can occur from nicotinamide?

As taking others medicines, taking nicotinamide can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Headache;
  • Lightheadedness or fainting;
  • Mild diarrhea, vomiting, or upset stomach;
  • Muscle pain, tenderness, or weakness;
  • Vision changes.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with nicotinamide?

Nicotinamide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, such as:







Vitamin supplements;

Nitrate medicine such as Nitroglycerin















Does food or alcohol interact with nicotinamide?

Nicotinamide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with nicotinamide?

Nicotinamide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as angina (chest pain) or low blood pressure, history of liver or gallbladder disease, ulcers, gout, or jaundice (skin or eyes turn yellow).


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using nicotinamide.

What is the dose of nicotinamide for an adult?

Consult your doctor for information about the dose of nicotinamide hydrochloride.

Recommended doses in some cases are listed below:

  • For age-related macular disease (eye disease), 500 milligrams of immediate-release niacin can be taken by mouth.
  • For preventing clogged arteries, 3,000-4,000 milligrams of niacin can be taken by mouth daily alone or in combination with other cholesterol therapy for 0.5-6.2 years.
  • For heart disease, 0.125-12 grams of niacin can be taken by mouth daily for up to five years.
  • For erectile dysfunction, 500-1,500 milligrams of niacin (Niaspan®) can be taken by mouth for 12 weeks.
  • For high cholesterol, 300-1,2000 milligrams of niacin can be taken by mouth daily for 6-44 weeks as wax-matrix, immediate-release (crystalline); 2 grams of niacin can be injected into the vein over 11 hours. The maximum recommended daily dose is 3 grams.
  • For high cholesterol (in combination with statins or bile acid sequestrants) 500-4,000 milligrams of extended-release or regular niacin can be taken by mouth daily for eight weeks to 6.2 years. Extended-or sustained-release niacin may be started at a dose of 500 milligrams daily and titrated up to 3 grams daily.
  • For high cholesterol levels in HIV-infected patients 500-2,000 milligrams of extended-release niacin (Niaspan®) can be taken by mouth daily for 44 weeks to two years.
  • For high blood phosphorous levels, a single 375 milligram dose of extended-release nicotinic acid can be taken by mouth.
  • For osteoarthritis, 3 grams of niacinamide can be taken by mouth daily for 12 weeks.
  • For pellagra or niacin deficiency, 50-1,000 milligrams of niacin can be taken by mouth daily.
  • For skin conditions, 2-5% of niacinamide cream can be applied to the skin for up to 12 weeks.
  • For type 1 diabetes mellitus prevention, 200-3,000 milligrams of niacinamide can be taken by mouth daily for up to one year; 20-40 milligrams per kilogram of niacinamide can be taken daily by mouth for up to one year and lacked evidence of benefit.
  • For type 2 diabetes, 0.5 grams of nicotinamide can be taken by mouth three times daily for six months.

What is the dose of nicotinamide for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is nicotinamide available?

Nicotinamide is available in the following dosage forms and strengths:

  • Capsules 250mg, 500mg, 1000 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of nicotinamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 6, 2016 | Last Modified: January 4, 2017