Neupogen

By Medically reviewed by hellodoktor

Generic Name: Neupogen Brand Name(s): Generics only. No brands available.

Uses

What is Neupogen® (filgrastim) used for?

Neupogen® is commonly used for the treatment of neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions.

Neupogen® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Neupogen® (filgrastim)?

Neupogen® should not be given within a day before or a day after you have chemotherapy.

Neupogen® is given into a vein or under the skin. Your care provider will show you the best places on your body to inject Neupogen® and how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Follow all directions on your prescription label. Do not use Neupogen® in larger or smaller amounts or for longer than recommended.

Neupogen® vials and prefilled syringes do not contain the same concentrations of this medicine. Do not give an injection unless you are trained in properly measuring your dose from either the vial or the prefilled syringe.

Do not shake the medicine. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it.

Use a different place each time you give an injection. Do not inject into the same place two times in a row.

Each single-use vial or prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. Do not use Neupogen® if the expiration date on the label has passed.

Ask your health care provider any questions you may have about how to use medication.

How do I store Neupogen® (filgrastim)?

Neupogen® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Neupogen® in the bathroom or the freezer. There may be different brands of Neupogen® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Neupogen® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Neupogen® (filgrastim)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Neupogen® or other medications.
  • You are receiving chemotherapy or radiation treatment.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Is it safe during pregnancy or breastfeeding?

Pregnancy

There are no adequate studies in women for determining risk when using Neupogen® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. Neupogen® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Breastfeeding:

Excretion in milk unknown; use with caution.

Always consult your health care provider prior to using Neupogen® if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Neupogen® (filgrastim)?

Here are side effects:

  • Allergic reaction (hives, sweating; dizziness, fast heart rate; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat)
  • Fever
  • Cough
  • Trouble breathing
  • Nosebleeds
  • Bone pain, muscle or joint pain
  • Diarrhea
  • Headache
  • Numbness
  • Rash, thinning hair

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Neupogen® (filgrastim)?

Neupogen® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

 

Does food or alcohol interact with Neupogen® (filgrastim)?

Neupogen® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

 

What health conditions may interact with Neupogen® (filgrastim)?

Neupogen® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as:

  • A blood cell disorder (e.g., sickle cell anemia)
  • Kidney disease
  • Fatal splenic rupture
  • Acute respiratory distress syndrome (ARDS)

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Neupogen® (filgrastim) for an adult?

Patients with cancer receiving myelosuppressive chemotherapy or induction and/or consolidation chemotherapy for acute myeloid leukemia:

The recommended starting dose is 5 mcg/kg/day subcutaneous injection, short intravenous infusion (15 to 30 minutes), or continuous intravenous infusion.

Patients with cancer undergoing bone marrow transplantation:

10mcg/kg/day given as an intravenous infusion no longer than 24 hours.

Patients undergoing autologous peripheral blood progenitor cell collection and therapy:

10 mcg/kg/day subcutaneous injection; administer for at least 4 days before first leukapheresis procedure and continue until last leukapheresis

Patients with congenital neutropenia:

The recommended starting dose is 6 mcg/kg subcutaneous injection twice daily.

Patients with cyclic or idiopathic neutropenia:

The recommended starting dose is 5 mcg/kg subcutaneous injection daily.

Patients acutely exposed to myelosuppressive doses of radiation:

10 mcg/kg/day subcutaneous injection.

What is the dose of Neupogen® (filgrastim) for a child?

Peripheral blood progenitor cell collection

As adults; 10 mcg/kg/day subcutaneous injection.

Initiate 4 days before leukapheresis; continue until last day of leukapheresis.

Myelosuppressive Chemotherapy Treatment (Off-label)

5-10 mcg/kg qDay intravenous /subcutaneous injection for 14 days.

Give daily until ANC >10,000/mm³.

Congenital neutropenia or agranulocytosis (off-label)

As adults: Initial 6 mcg/kg subcutaneous injection every 12 hours.

Dosage range: 3-15 mcg/kg/day subcutaneous injection daily or divided every 12 hours.

How is Neupogen® (filgrastim) available?

Neupogen® is available in the following dosage forms and strengths:

Vial

  • Injection: 300 mcg/ml in a single-dose vial.
  • Injection: 480 mcg/1.6 ml in a single-dose vial.

Prefilled syringe

  • Injection: 300 mcg/0.5 ml in a single-dose prefilled syringe.
  • Injection: 480 mcg/0.8 ml in a single-dose prefilled syringe.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Neupogen®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: December 29, 2016 | Last Modified: September 12, 2019

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