Nepafenac (Ophthalmic)

By Medically reviewed by hellodoktor

Generic Name: Nepafenac (Ophthalmic) Brand Name(s): Nepafenac (Ophthalmic).

Uses

What is Nepafenac (Ophthalmic) used for?

Nepafenac (Ophthalmic) is used to relieve eye pain, irritation, and redness following cataract eye surgery. Nepafenac belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). It works by blocking certain natural substances (prostaglandins) in your body that cause pain and swelling.

How should I take Nepafenac (Ophthalmic)?

Apply this medication to the operated eye(s) as directed by your doctor. The instructions for use depend on the strength of the eye drops prescribed. Follow your doctor’s instructions.

If you are using nepafenac 0.1% eye drops, apply it usually 3 times daily starting 1 day before surgery, and continue use on the day of surgery and for 2 weeks after surgery, or as directed by your doctor.

If you are using nepafenac 0.3% eye drops, apply it usually once daily starting 1 day before surgery, and continue use on the day of surgery and for 2 weeks after surgery, or as directed by your doctor. Your doctor may also instruct you to apply an additional drop one-half hour to 2 hours before surgery.

To apply eye drops, wash your hands first. Shake the bottle well before each dose. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

This medication should not be used while wearing contact lenses. Consult your doctor or pharmacist for details.

Tilt your head back, look upward, and gently pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

This medication is usually used for up to 14 days after eye surgery or as directed by your doctor. Do not start using this medication early, use it more often than prescribed, or continue using it for longer than directed by your doctor. Prolonged use of nepafenac eye drops (more than 2 weeks) may increase the risk of very serious side effects of the eye.

Inform your doctor if your condition persists or worsens.

How do I store Nepafenac (Ophthalmic)?

Nepafenac (Ophthalmic) is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Nepafenac (Ophthalmic) in the bathroom or the freezer. There may be different brands of Nepafenac (Ophthalmic) that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Nepafenac (Ophthalmic) down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Nepafenac (Ophthalmic)?

Before using nepafenac, tell your doctor or pharmacist if you are allergic to it; or to aspirin, or to other NSAIDs (e.g., ibuprofen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, previous eye surgery, other eye problems (e.g., dry eye syndrome, corneal problems), diabetes, rheumatoid arthritis, asthma, nasal polyps.

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Nepafenac (Ophthalmic) during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Nepafenac (Ophthalmic). Nepafenac (Ophthalmic) is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Nepafenac (Ophthalmic)?

This medication may temporarily sting or burn your eyes for 1-2 minutes when applied. Eye redness and headache may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: eye swelling, eye discharge/extreme watering.

Tell your doctor right away if any of these rare but very serious side effects occur: vision changes, eye pain.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Nepafenac (Ophthalmic)?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: anti-platelet medications (e.g., clopidogrel), “blood thinners” (e.g., warfarin), corticosteroid drugs (e.g., prednisone), other eye medications (e.g., corticosteroid eye drops).

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) which, if used together with nepafenac, may increase your risk for bleeding. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.

Nepafenac (Ophthalmic) may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Nepafenac (Ophthalmic)?

Nepafenac (Ophthalmic) may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Nepafenac (Ophthalmic)?

Nepafenac (Ophthalmic) may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Nepafenac (Ophthalmic).

What is the dose of Nepafenac (Ophthalmic) for an adult?

Usual Adult Dose for Postoperative Ocular Inflammation

0.1% suspension: 1 drop should be applied to the affected eye 3 times per day beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period

0.3% suspension: 1 drop should be applied to the affected eye once a day beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period; an additional drop should be administered 30 to 120 minutes prior to surgery

Comments:

-This drug may be administered in conjunction with other topical ophthalmic drugs such as beta-blockers, carbonic anhydrase inhibitors, alpha-agonists, cycloplegics, and mydriatics.

-If more than one topical ophthalmic drug is being used, these drugs should be administered at least 5 minutes apart.

Use: Treatment of pain and inflammation associated with cataract surgery

Other Comments

Administration advice:

-This drug should not be injected.

Patient advice:

-Patients should be instructed not to swallow this drug.

-Patients should be instructed to avoid sunlight during treatment.

-Care should be taken not to touch the eyelids, surrounding areas or other surfaces with the dropper tip of the bottle.

-Patients should be instructed to shake the bottle well before use.

Storage requirements:

-Protect from light

-Bottle should be kept tightly closed when not in use.

What is the dose of Nepafenac (Ophthalmic) for a child?

Usual Pediatric Dose for Postoperative Ocular Inflammation

10 years or older:

0.1% suspension: 1 drop should be applied to the affected eye 3 times per day beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period

0.3% suspension: 1 drop should be applied to the affected eye once a day beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period; an additional drop should be administered 30 to 120 minutes prior to surgery

Comments:

-This drug may be administered in conjunction with other topical ophthalmic drugs such as beta-blockers, carbonic anhydrase inhibitors, alpha-agonists, cycloplegics, and mydriatics.

-If more than one topical ophthalmic drug is being used, these drugs should be administered at least 5 minutes apart.

Use: Treatment of pain and inflammation associated with cataract surgery

Precautions

Safety and efficacy have not been established in patients younger than 10 years.

How is Nepafenac (Ophthalmic) available?

Nepafenac (Ophthalmic) is available in the following dosage forms and strengths:

  • Ophthalmic suspension

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Nepafenac (Ophthalmic), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 5, 2018 | Last Modified: September 12, 2019

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