What is Nateglinide used for?
Nateglinide is used alone or with other medications to control high blood sugar along with a proper diet and exercise program. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It works by stimulating the body to produce more insulin. Insulin is a natural substance that allows the body to properly use sugar from the diet.
How should I take Nateglinide?
Take this medication by mouth 1-30 minutes before each main meal, usually 3 times daily, or as directed by your doctor. Take this drug no earlier than 30 minutes before the meal. Do not take a dose of medication if you are skipping that meal.
If you are having liquid meals, a higher dose of this medication may be necessary to control your blood sugar. Consult your doctor for more details.
The dosage is based on your medical condition, number of meals per day, and response to treatment.
Use this medication regularly as directed by your doctor in order to get the most benefit from it. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.
Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. This is very important in order to determine the correct dose. Tell your doctor if your blood sugar measurements are too high or too low. Your treatment plan may need to be changed.
How do I store Nateglinide?
Nateglinide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Nateglinide in the bathroom or the freezer. There may be different brands of Nateglinide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Nateglinide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using Nateglinide?
Before taking nateglinide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
Limit alcohol while taking this medication because it can increase the risk of developing low blood sugar.
During times of stress, such as fever, infection, injury, or surgery, it may be more difficult to control your blood sugar. Consult your doctor because increased stress may require a change in your treatment plan, medications, or blood sugar testing.
During pregnancy, this medication should be used only when clearly needed. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy. Discuss the risks and benefits of different treatments (such as diet, exercise, and medications including insulin).
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Is it safe during pregnancy or breast-feeding?
There are no adequate studies in women for determining risk when using this Nateglinide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Nateglinide. Nateglinide is pregnancy risk category C according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk,
- B=No risk in some studies,
- C=There may be some risk,
- D=Positive evidence of risk,
What side effects can occur from Nateglinide?
Weight gain may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Nateglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes. Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar. Symptoms may include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose, raise your blood sugar quickly by eating a quick source of sugar such as table sugar, honey, candy, or drinking a glass of fruit juice or non-diet soda. Check with your doctor or pharmacist to find out what you should do if you miss a meal.
Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medication(s).
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Nateglinide?
Many drugs can affect your blood sugar, making it harder to control. Examples include corticosteroids (such as prednisone), psychiatric medicines (such as olanzapine), fluoroquinolone antibiotics (such as ciprofloxacin), among others. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Check the labels on all your nonprescription medicines (such as cough-and-cold products) because they may contain ingredients that could affect your blood sugar. Ask your pharmacist about the safe use of those products.
Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.
Other medications can affect the results of urine tests for sugar or ketones. Consult your doctor or pharmacist for more information.
Nateglinide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Nateglinide?
Nateglinide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Nateglinide?
Nateglinide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Nateglinide.
What is the dose of Nateglinide for an adult?
Usual Adult Dose for Diabetes Type 2
Initial dose: 120 mg orally 3 times a day before meals
Maintenance dose: 60 to 120 mg orally 3 times a day before meals
-For patients who are near goal HbA1c when therapy is initiated, therapy should be initiated at 60 mg orally 3 times.
-May be used as monotherapy, or in combination with metformin or a thiazolidinedione.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Mild hepatic impairment: No adjustment recommended
Moderate to severe hepatic impairment: Use caution
Elderly: No adjustment recommended; however, some individuals may have a greater sensitivity to therapy.
Insulin therapy may be temporarily needed in times of fever, infection, trauma, or surgery.
-Take orally 1 to 30 minutes before a meal.
-Patients who skip a meal should be instructed to skip the dose for that meal.
-This drug is not indicated to treat patients with type 1 diabetes or diabetic ketoacidosis as these conditions should be treated with insulin.
-Secondary failure may occur; prior to classifying a patient as a secondary failure it is important to assess dose and dietary adherence.
-Periodic measures of fasting blood glucose and glycosylated hemoglobin should be performed to assess efficacy.
-Patients should understand the importance of adhering to dietary instructions and regular physical activity; patients should understand strenuous exercise and alcohol intake may increase the risk of hypoglycemia.
-Patients should be aware of the symptoms of hypoglycemia and its management; they should be cautioned about driving and the use of machinery, especially when optimum stabilization has not been achieved, e.g., during a transition from other medications or during irregular use.
-During periods of stress such as fever, trauma, infection, or surgery, management of diabetes may change and patients should be advised to seek medical advice.
-Drug interactions may occur and patients should speak with their healthcare provider regarding all their medications, prescription and over the counter drugs.
-Advise patient to speak to physician or health care professional if pregnant, intend to become pregnant, or are breastfeeding.
What is the dose of Nateglinide for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is Nateglinide available?
Nateglinide is available in the following dosage forms and strengths:
- Oral tablet
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Nateglinide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Nateglinide Dosage. https://www.drugs.com/dosage/nateglinide.html. Accessed March 27, 2018.
Nateglinide. https://www.webmd.com/drugs/2/drug-20313/nateglinide-oral/details. Accessed March 27, 2018.
Review Date: April 5, 2018 | Last Modified: April 5, 2018