Generic Name: Narcan Brand Name(s): Generics only. No brands available.

Uses

What is Narcan® (naloxone hydrochloride) used for?

Narcan® is commonly used for completely or partially reversing the effects of narcotics. It may also be used to diagnose overdose of narcotics. It may also be used for other conditions as determined by your doctor.

Narcan® is a narcotic antagonist. It works by blocking opiate receptor sites, which reverses or prevents toxic effects of narcotic (opioid) analgesics.

How should I take Narcan® (naloxone hydrochloride)?

Use Narcan® as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Narcan® is usually given as an injection at your doctor’s office, hospital, or clinic.

Do not use Narcan® if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Ask your health care provider any questions you may have about how to use Narcan®.

How do I store Narcan® (naloxone hydrochloride)?

Narcan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Narcan® in the bathroom or the freezer. There may be different brands of Narcan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Narcan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Narcan® (naloxone hydrochloride)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Narcan® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have heart disease or a history of substance abuse.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Narcan® (naloxone hydrochloride)?

Common side effects are:

  • Change in mood
  • Increased sweating
  • Nausea
  • Nervousness
  • Restlessness
  • Trembling
  • Vomiting

Call your doctor immediately if you have:

  • Severe allergic reactions: rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue
  • Dizziness
  • Fainting
  • Fast or irregular pulse
  • Flushing, headache
  • Heart rhythm changes
  • Seizures
  • Sudden chest pain

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Narcan® (naloxone hydrochloride)?

Narcan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

If you are using any narcotic pain medication, the pain-relieving effects of the narcotic will be reversed while you are also receiving naloxone (Narcan®).

Tell your doctor about all other medicines you use, especially:

  • Buprenorphine (Buprenex, Subutex)
  • Methohexital (Brevital)
  • Narcotic pain medication such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), oxycodone (OxyContin, Percocet), fentanyl (Actiq, Duragesic), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), and many others

Does food or alcohol interact with Narcan® (naloxone hydrochloride)?

Narcan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Narcan® (naloxone hydrochloride)?

Narcan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • CV Disorders
  • Liver Disease
  • Renal
  • Septic Shock

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Narcan® (naloxone hydrochloride) for an adult?

Initial Dosing

The recommended initial dose of Narcan® Nasal Spray is one spray delivered by intranasal administration into one nostril.

Repeated Dosing

Seek emergency medical assistance as soon as possible after administering the first dose of Narcan® Nasal Spray.

The requirement for repeat doses of Narcan® Nasal Spray depends upon the amount, type, and route of administration of the opioid being antagonized.

Administer Narcan® Nasal Spray in alternate nostrils with each dose.

If the patient responds to Narcan® Nasal Spray and relapses back into respiratory depression before emergency assistance arrives, administer an additional dose of Narcan® Nasal Spray, using a new Narcan® Nasal Spray and continue surveillance of the patient.

If the desired response is not obtained after 2 or 3 minutes, administer an additional dose of Narcan® Nasal Spray using a new Narcan® Nasal Spray. If there is still no response and additional doses are available, administer additional doses of Narcan® Nasal Spray every 2 to 3 minutes using a new Narcan® Nasal Spray with each dose until emergency medical assistance arrives.

Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.

What is the dose of Narcan® (naloxone hydrochloride) for a child?

Initial Dosing

The recommended initial dose of Narcan® Nasal Spray is one spray delivered by intranasal administration into one nostril.

Repeated Dosing

Seek emergency medical assistance as soon as possible after administering the first dose of Narcan® Nasal Spray.

The requirement for repeat doses of Narcan® Nasal Spray depends upon the amount, type, and route of administration of the opioid being antagonized.

Administer Narcan® Nasal Spray in alternate nostrils with each dose.

If the patient responds to Narcan® Nasal Spray and relapses back into respiratory depression before emergency assistance arrives, administer an additional dose of Narcan® Nasal Spray, using a new Narcan® Nasal Spray and continue surveillance of the patient.

If the desired response is not obtained after 2 or 3 minutes, administer an additional dose of Narcan® Nasal Spray using a new Narcan® Nasal Spray. If there is still no response and additional doses are available, administer additional doses of Narcan®  Nasal Spray every 2 to 3 minutes using a new Narcan® Nasal Spray with each dose until emergency medical assistance arrives.

Additional supportive and/or resuscitative measures may be helpful while awaiting emergency medical assistance.

How is Narcan® (naloxone hydrochloride) available?

Narcan® is available in the following dosage forms and strengths:

  • Nasal spray: naloxone hydrochloride 4mg in 0.1mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Overdose symptoms may include seizure (convulsions), feeling light-headed, or fainting.

What should I do if I miss a dose?

If you miss a dose of Narcan®, contact your doctor right away.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: July 23, 2017 | Last Modified: July 23, 2017

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