Moexipril

By Medically reviewed by hellodoktor

Generic Name: Moexipril Brand Name(s): Moexipril.

Uses

What is Moexipril used for?

Moexipril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Moexipril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily.

How should I take Moexipril?

Take this medication by mouth on an empty stomach 1 hour before a meal as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

It may take several weeks before you get the full benefit of this drug.

Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase).

How do I store Moexipril?

Moexipril is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Moexipril in the bathroom or the freezer. There may be different brands of Moexipril that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Moexipril down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Moexipril?

Before taking moexipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as captopril, lisinopril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, liver disease.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and high potassium levels.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. See also Warning section.

It is unknown if moexipril passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Moexipril during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Moexipril. Moexipril is pregnancy risk category D  according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Moexipril?

Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), fainting.

Although moexipril may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause kidney problems or make them worse. Your doctor will check your kidney function while you are taking this medication. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Moexipril?

Some products that may interact with this drug include: aliskiren, gold injections, lithium, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking moexipril. Make sure all your doctors know which medicines you are using.

Moexipril may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Moexipril?

Moexipril may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Moexipril?

Moexipril may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Moexipril.

What is the dose of Moexipril for an adult?

Usual Adult Dose for Hypertension

Initial dose:

-Patients not receiving diuretic therapy: 7.5 mg orally once a day 1 hour before meals

-Patients receiving diuretic therapy: 3.75 mg orally once a day 1 hour before meals

Maintenance dose: 7.5 to 30 mg orally per day in 1 or 2 divided doses 1 hour before meals.

Maximum dose: 60 mg/day

Comments:

-Diuretic therapy should be discontinued, if possible, 2 to 3 days before starting this drug. If blood pressure remains uncontrolled with this drug alone, diuretic therapy may be restarted. If diuretic therapy cannot be discontinued, initiate this drug at a lower dose.

-Total daily doses above 60 mg have not been studied in hypertensive patients.

-The antihypertensive effect of this drug may diminish toward the end of the dosing interval. Therefore, measure blood pressure just prior to dosing.

Renal Dose Adjustments

CrCl 40 mL/min/1.73 m2 or less: Initial dose: 3.75 mg orally once a day 1 hour before meals; Maximum dose: 15 mg/day

Dose Adjustments

The antihypertensive effect of moexipril may diminish towards the end of the dosing interval. Blood pressure should, therefore, be measured just prior to dosing to determine whether satisfactory blood pressure control is obtained. If control is not adequate, increased dose or divided dosing can be tried.

Other Comments

Administration advice: Should be taken 1 hour before meals.

Monitoring:

-Monitor serum electrolytes periodically.

-Monitor renal function during the first few weeks of therapy.

-Consider monitoring white blood cell counts in patients with collagen vascular disease, especially if the disease is associated with impaired renal function.

Patient advice:

-Advise patients to immediately report any signs or symptoms of angioedema (breathing difficulty or swelling of face, extremities, eyes, lips, or tongue) and to stop taking this drug until consulting a physician.

-Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician.

-Caution patients to consult their physician if excessive perspiration, dehydration, vomiting, or diarrhea occurs as it may lead to excessive blood pressure reduction due to reduced fluid volume.

-Advise patients against using potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes without consulting their physician.

-Tell patients to promptly report any sign of infection (e.g., sore throat, fever), which may be a sign of neutropenia.

-Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.

What is the dose of Moexipril for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Moexipril available?

Moexipril is available in the following dosage forms and strengths:

  • Oral tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Moexipril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 29, 2018 | Last Modified: September 12, 2019

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