Generic Name: Methotrimeprazine Brand Name(s): Generics only. No brands available.


What is methotrimeprazine used for?

Methotrimeprazine, also known as Levomepromazine, is commonly used for treating mental and emotional disorders, including schizophrenia, manic-depressive syndromes, and other psychotic disorders. It can also be used in conditions associated with anxiety and tension, as a pain reliever (for certain types of pain), as a sedative, and for nausea and vomiting caused by certain conditions.

How should I take methotrimeprazine?

Take this medication as directed. This may be taken with food if it upsets your stomach. Do not increase your dose or take this more often without your doctor’s approval.

If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How do I store methotrimeprazine?

Methotrimeprazine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store methotrimeprazine in the bathroom or the freezer. There may be different brands of methotrimeprazine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush methotrimeprazine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using methotrimeprazine?

Do not take methotrimeprazine if you:

  • Are allergic to methotrimeprazine, or any ingredient of this medication.
  • Are allergic to other phenothiazines (e.g., chlorpromazine).
  • Are excessively sedated by alcohol, sleeping pills, tranquilizers, pain relievers, or narcotics.
  • Have a blood disorder.
  • Have liver problems.
  • Have brain damage.
  • Have pheochromocytoma (a tumour in the adrenal glands).
  • Are being treated with regional or spinal pain relief (epidural infusion).
  • Are experiencing severely low blood pressure or severe heart disorder.

Is it safe during pregnancy or breastfeeding?


This medication should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who used methotrimeprazine in the later part of pregnancy have had abnormal muscle movement and withdrawal symptoms, including decreased muscle tone, sleepiness, difficulty feeding and severe difficulty breathing after birth. These symptoms can be severe and need medical attention. If you become pregnant while taking this medication, contact your doctor immediately.


Methotrimeprazine passes into breast milk. If you are a breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.

Side effects

What side effects can occur from methotrimeprazine?

Drowsiness, dry mouth or constipation may occur especially the first several days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor.

Also, notify your doctor if you develop a skin rash, rapid or pounding heartbeat, difficulty urinating, unusual or jerky movements, yellowing of the skin or eyes, mental confusion, unusual weakness.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist


What drugs may interact with methotrimeprazine?

Methotrimeprazine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Narcotic pain relievers
  • Seizure medication
  • Sleep agents
  • Tranquilizers
  • Allergy medication

Does food or alcohol interact with methotrimeprazine?

Methotrimeprazine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with methotrimeprazine?

Methotrimeprazine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using methotrimeprazine.

What is the dose of methotrimeprazine for an adult?

The dose of this medication varies widely depending on the condition being treated and the circumstances and age of the person being treated.

What is the dose of methotrimeprazine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is methotrimeprazine available?

Methotrimeprazine is available in the following dosage forms and strengths:

  • Methotrimeprazine 5 mg, tablets
  • Methotrimeprazine 25 mg tablets
  • Methotrimeprazine 50 mg tablets

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of methotrimeprazine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: February 7, 2017 | Last Modified: February 7, 2017

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