Memantine

By

Generic Name: Memantine Brand Name(s): Generics only. No brands available.

Uses

What is Memantine used for?

Memantine is used to treat moderate to severe confusion (dementia) related to Alzheimer’s disease. It does not cure Alzheimer’s disease, but it may improve memory, awareness, and the ability to perform daily functions. This medication works by blocking the action of a certain natural substance in the brain (glutamate) that is believed to be linked to symptoms of Alzheimer’s disease.

How should I take Memantine?

Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. When you first start taking this medication, you will usually take it once daily. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Once your dose increases to more than 5 milligrams per day, take this medication twice daily or as directed by your doctor.

If you are taking memantine oral liquid, read the manufacturer’s instruction sheet that comes with the bottle. Follow the directions exactly. Use the oral syringe that comes with the product to measure out your dose. Do not use a household spoon because you may not get the correct dose. Swallow the medication directly from the syringe. Do not mix it with water or other liquids. Rinse the syringe with water after each use. Consult your doctor or pharmacist if you have any questions.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition worsens.

How do I store Memantine?

Memantine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Memantine in the bathroom or the freezer. There may be different brands of Memantine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Memantine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Memantine?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, severe urinary tract infections, recent dietary change (from a high-protein diet to a vegetarian diet).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Memantine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Memantine. Memantine is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Memantine?

Body aches, dizziness, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Memantine?

Some products that may interact with this drug include: carbonic anhydrase inhibitors (such as acetazolamide, methazolamide), sodium bicarbonate.

Memantine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Memantine?

Memantine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Memantine?

Memantine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Memantine.

What is the dose of Memantine for an adult?

Usual Adult Dose for Alzheimer’s Disease

IMMEDIATE-RELEASE:

Week 1: 5 mg orally once a day.

Week 2: 10 mg orally/day (Administer 5 mg twice a day.)

Week 3: 15 mg orally/day (Administer 5 mg and 10 mg as separate doses.)

Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day.)

EXTENDED-RELEASE:

-Initial Dose: 7 mg orally once a day.

-Maintenance and Maximum Dose: 28 mg orally once a day; increase the initial dose in 7 mg increments to the recommended maintenance dose.

Comments: The minimum recommended interval between dose increases is one week; only increase dosage if the previous dose has been well tolerated.

Use: Treatment of moderate to severe dementia of the Alzheimer’s type.

Renal Dose Adjustments

-Mild and Moderate Renal Impairment (CrCl 30 to 80 mL/min): No adjustment recommended.

-Severe Renal Impairment (CrCl 5 to 29 mL/min): Immediate-Release: 5 mg orally twice a day; Extended-Release (Maintenance and Maximum Dose): 14 mg orally once a day.

Liver Dose Adjustments

-Mild and Moderate Hepatic Impairment (Child-Pugh A and B): No adjustment recommended.

-Severe Hepatic Impairment (Child-Pugh C): Immediate-Release: Use with caution; Extended-Release: Data not available.

Dose Adjustments

SWITCHING FROM IMMEDIATE-RELEASE (IR) TO EXTENDED RELEASE (XR):

-Patient on Regimen of 10 Mg IR Twice a Day: Switch to 28 mg XR once a day on the day following the last dose of the IR drug.

-Patients with Severe Renal Impairment (CrCl 5 to 29 mL/min): Switch to 14 mg XR once a day on the day following the last dose of the IR drug.

-Comments: There is no study data addressing the comparative efficacy of the 10 mg IR twice a day and 28 mg XR once a day regimens.

FAILING TO TAKE THE DRUG (IR or XR) FOR SEVERAL DAYS: Consider resuming treatment at a lower dose and re-titrate according to the standard titration scheme.

What is the dose of Memantine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Memantine available?

Memantine is available in the following dosage forms and strengths:

  • Oral tablet,
  • Oral kit,
  • Oral solution,
  • Oral capsule, extended release.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Memantine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 23, 2018 | Last Modified: March 23, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.
You might also like