Generic Name: Medrol Brand Name(s): Generics only. No brands available.


What is Medrol® (methylprednisolone) used for?

Medrol® is used for treating severe allergies, arthritis, asthma, certain blood disorders, and skin conditions. It may also be used for other conditions as determined by your doctor.

How should I take Medrol® (methylprednisolone)?

Use Medrol® as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Medrol® by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Ask your health care provider any questions you may have about how to use Medrol®.

How do I store Medrol® (methylprednisolone)?

Medrol® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Medrol® in the bathroom or the freezer. There may be different brands of Medrol® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Medrol® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Medrol® (methylprednisolone)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Medrol® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have a history of heart problems (e.g., congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, or any mental or mood problems.
  • You have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles.
  • You have HIV or tuberculosis (TB), or if you have ever had a positive TB skin test.
  • You have any stomach problems (e.g., ulcers), intestinal problems (e.g., blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus.
  • You have weak bones (e.g., osteoporosis) or muscle problems (e.g., myasthenia gravis).
  • You have had any recent vaccinations (e.g., smallpox).

Do not use Medrol® if:

  • You are taking mifepristone.
  • You have a systemic fungal infection.
  • You are scheduled to have a smallpox vaccine.

Medrol® may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Notify your doctor of any signs of infection, including fever, sore throat, rashes, or chills, within 12 months after stopping Medrol® (methylprednisolone).

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Medrol® may cause serious increases in blood pressure, salt and water retention, and increased potassium loss. Dietary salt restriction and potassium supplements may be necessary.

Medrol® may cause calcium loss and can promote the development of osteoporosis (brittle bones). Take adequate calcium and vitamin D supplements.

Tell your doctor or dentist that you take Medrol® before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients – Medrol® may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Talk with your doctor before you receive any vaccine.

Lab tests, such as adrenal function tests or blood pressure monitoring, may be performed while you use Medrol®. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Medrol®.

Medrol® should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Medrol® (methylprednisolone)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Dizziness
  • Facial flushing
  • Feeling of whirling motion
  • Headache
  • Increased sweating

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Bloody, black, or tarry stools
  • Changes in body fat
  • Changes in menstrual period
  • Chest pain
  • Fainting
  • Fever, chills, or sore throat
  • Increased hunger, thirst, or urination
  • Mental or mood changes
  • Muscle pain, weakness, or wasting
  • Seizures
  • Severe nausea or vomiting
  • Slow wound healing
  • Stomach pain
  • Sudden, severe dizziness or headache
  • Swelling of the feet or legs
  • Tendon, bone, or joint pain
  • Thinning of the skin
  • Unusual bruising or bleeding
  • Unusual skin sensation
  • Unusual weight gain
  • Vision changes or other eye problems
  • Vomit that looks like coffee grounds

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Medrol® (methylprednisolone)?

Medrol® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Barbiturates (e.g., phenobarbital), carbamazepine, hydantoins (e.g., phenytoin), lithium, or rifampin because they may decrease Medrol® (methylprednisolone)’s effectiveness.
  • Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems, may occur.
  • Aspirin, live vaccines, mifepristone, or ritodrine because their actions and the risk of their side effects may be increased by Medrol® (methylprednisolone)

Does food or alcohol interact with Medrol® (methylprednisolone)?

Medrol® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Medrol® (methylprednisolone)?

Medrol® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Medrol® (methylprednisolone).

What is the dose of Medrol® (methylprednisolone) for an adult?

Allergic Conditions

Day 1: 8 mg PO before breakfast, 4 mg after lunch and after dinner, and 8 mg at bedtime

Day 2: 4 mg PO before breakfast, after lunch, and after dinner and 8 mg at bedtime

Day 3: 4 mg PO before breakfast, after lunch, after dinner, and at bedtime

Day 4: 4 mg PO before breakfast, after lunch, and at bedtime

Day 5: 4 mg PO before breakfast and at bedtime

Day 6: 4 mg PO before breakfast

May be tapered over 12 days (to decrease chance of dermatitis flareup)

Acute Exacerbations of Multiple Sclerosis

160 mg IV once daily for 1 week, then 64 mg IV every other day for 1 month

Pneumocystis (carinii) jiroveci Pneumonia in AIDS Patients (Off-label)

30 mg IV q12hr for 5 days, then 30 mg IV q24hr for 5 days, then 15 mg IV q24hr for 11 days

Acute Spinal Cord Injury (Off-label)

1st hour: 30 mg/kg IV over 15 minutes.

Next 23 hours: 5.4 mg/kg/hr IV by continuous infusion

Severe Lupus Nephritis (Off-label)

0.5-1 g IV over 1 hour once daily for 3 days

What is the dose of Medrol® (methylprednisolone) for a child?


0.5-1.7 mg/kg/day IV/PO/IM divided q12hr.

Status Asthmaticus

<12 years: 1-2 mg/kg IV/IM in 2 divided doses until peak expiratory flow is 70% of predicted or personal best; not to exceed 60 mg/day.

>12 years: 40-80 mg/day IM divided q12-24hr until peak expiratory flow is 70% of predicted or personal best; not to exceed 60 mg/day.

Pneumocystis (carinii) jiroveci Pneumonia in AIDS Patients (Off-label)

>13 years: 30 mg IV q12hr for 5 days, then 30 mg IV q24hr for 5 days, then 15 mg IV q24hr for 11 days

Severe Lupus Nephritis (Off-label)

30 mg/kg IV every other day for 6 doses

How is Medrol® (methylprednisolone) available?

Medrol® is available in the following dosage forms and strengths:

  • Tablet: 4mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Medrol®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 10, 2017 | Last Modified: September 2, 2017

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