Generic Name: Magnevist Brand Name(s): Generics only. No brands available.

Uses

What is Magnevist® (gadopentetate dimeglumine) used for?

Magnevist® is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

Magnevist® is used to help diagnose certain disorders of the brain, blood vessels, and spin (central nervous system).

Magnevist® may also be used for other purposes, ask your doctor for more information.

How should I take Magnevist® (gadopentetate dimeglumine)?

Magnevist® is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

How do I store Magnevist® (gadopentetate dimeglumine)?

Magnevist® injection should be stored at controlled room temperature, between 15 – 30° C and protected from light. Do not freeze. Should freezing occur in the vial, Magnevist® injection should be brought to room temperature before use. If allowed to stand at room temperature for a minimum of 90 minutes, Magnevist® injection should return to a clear, colorless to slightly yellow solution. Before use, examine the product to assure that all solids are re-dissolved and that the container and closure have not been damaged. Should solids persist, discard vial.

Precautions & warnings

What should I know before using Magnevist® (gadopentetate dimeglumine)?

Before using this drug, tell your doctor if:

  • You have kidney disease or if you are on dialysis. You may not be able to receive Magnevist®.
  • You have recently received any contrast agent similar to gadopentetate dimeglumine.
  • You have diabetes, high blood pressure, liver disease, a heart rhythm disorder, asthma or allergies.
  • You are over 60 years old.
  • You have ever had a reaction to a contrast agent.
  • You have recently had an injury, surgery, or severe infection.

Magnevist® can cause a life-threatening condition in people with advanced kidney disease. The symptoms of this condition include:

  • Burning, itching, swelling, scaling, and tightening or hardening of your skin
  • Muscle weakness
  • Joint stiffness in your arms, hands, legs, or feet
  • Deep bone pain in your ribs or your hips
  • Trouble moving
  • Skin redness or discoloration

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Magnevist® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Magnevist®. Magnevist® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Magnevist® (gadopentetate dimeglumine)?

Less serious side effects may include:

  • Headache
  • Dizziness
  • Nausea
  • Feeling unusually hot
  • Unusual or unpleasant taste in your mouth
  • Flushing (warmth, redness, or tingly feeling)
  • Numbness
  • Cold feeling, warmth, pain, or burning (where the medicine was injected)

Tell your caregivers at once if you have a serious side effect such as:

  • Urinating less than usual or not at all
  • Drowsiness
  • Confusion
  • Mood changes
  • Increased thirst
  • Loss of appetite
  • Swelling
  • Weight gain
  • Feeling short of breath
  • Swelling, bruising, redness, itching, burning, or skin changes (where the injection was given)

Get emergency medical help if you have any of these signs of an allergic reaction to Magnevist® including hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Magnevist® (gadopentetate dimeglumine)?

Magnevist® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

These products may include:

  • Lithium (Eskalith, Lithobid)
  • methotrexate (Rheumatrex, Trexall)
  • pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others
  • Medicines treating ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine)
  • Medicines preventing organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf)
  • IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled)
  • Antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte)
  • Cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid)

Does food or alcohol interact with Magnevist® (gadopentetate dimeglumine)?

Magnevist® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Magnevist® (gadopentetate dimeglumine)?

Magnevist® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially, if you have any of these other conditions:

  • Diabetes
  • High blood pressure
  • Liver disease
  • A heart rhythm disorder
  • Asthma
  • Hay fever
  • A history of food or drug allergies

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Magnevist® (gadopentetate dimeglumine).

What is the dose of Magnevist® (gadopentetate dimeglumine) for an adult?

MRI Contrast Agent

The recommended dose is 0.2 ml/kg IV bolus; not to exceed infusion rate of 10 mL/15 seconds.

What is the dose of Magnevist® (gadopentetate dimeglumine) for a child?

MRI Contrast Agent

<2 years: Safety and efficacy not established.

>2 years: As adults; 0.2 mL/kg IV bolus; not to exceed infusion rate of 10 ml/15 seconds.

How is Magnevist® (gadopentetate dimeglumine) available?

Magnevist® is available in the following dosage forms and strengths:

  • Magnevist® 10 mmol/20 ml (469.01 mg/ml) solution
  • Magnevist® 10 mmol/20 ml (469.01 mg/ml) syringe
  • Magnevist® 2.5 mmol/5 ml (469.01 mg/ml) solution
  • Magnevist® 469.01 mg/ml (46.9 %) solution
  • Magnevist® 5 mmol/10 ml (469.01 mg/ml) solution
  • Magnevist® 7.5 mmol/15 ml (469.01 mg/ml) solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

Since Magnevist® is used only during your MRI, you will not be on a dosing schedule.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 25, 2017 | Last Modified: March 25, 2017

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