Mafenide

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Generic Name: Mafenide Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Mafenide used for?

Mafenide is used alone or with other medications to help prevent and treat wound infections in patients with severe burns. Mafenide is a drug applied to the skin that belongs to a class of drugs known as sulfa antibiotics. It works by killing bacteria that may infect an open wound. Killing bacteria helps to promote wound healing and to decrease the risk of the bacteria spreading to surrounding skin or to the blood, thereby helping to prevent a serious blood infection (sepsis).

How should I take Mafenide?

Wash hands before and after using this medication. Use this medication on the skin only. After cleaning the affected area, apply this medication to the wound while wearing a clean pair of medical gloves (e.g., latex, vinyl), usually once or twice daily or as directed by your doctor. The layer of cream should be about one-sixteenth of 1 to 2 millimeters thick. The wound should be covered with this medication at all times. Bandages do not need to be used to cover the wound. If some of the cream rubs off the wound, re-apply it right away. Length of treatment is based on your medical condition and response to treatment.

Do not stop using this medication until told to do so by your doctor.

If possible, bathe at least once a day to help remove the dead skin from the wound to allow healing to occur. Be sure to re-apply this medication after bathing.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition persists or worsens or if you notice increasing redness/tenderness of the skin around the wound.

How do I store Mafenide?

-Cream: Dispense in a tight, light resistant container; avoid exposure to excessive heat (above 104F or 40C)

-Packets: Store in a cool, dry place.

-Reconstituted solution: Use within 48 hours of preparation.

There may be different brands of Mafenide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Mafenide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Mafenide?

Before using mafenide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (including preservatives such as parabens, sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung problems (e.g., asthma), kidney disease, metabolism problems (e.g., glucose-6-phosphate dehydrogenase deficiency-G6PD), blood disorders.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Mafenide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Mafenide. Mafenide is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Mafenide?

Pain, burning, or redness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: blisters, bleeding, fast breathing, nausea, vomiting, diarrhea, headache, change in alertness, shaking (tremors), seizures.

Tell your doctor right away if any of these rare but very serious side effects occur: weakness, dark urine, stomach/abdominal pain, arm/leg/back pain, fast heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Mafenide?

Mafenide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Mafenide?

Mafenide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Mafenide?

Mafenide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Mafenide.

What is the dose of Mafenide for an adult?

Usual Adult Dose for Bacterial Infection

Solution: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:

-Discontinue treatment if allergic manifestations occur.

-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.

-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.

-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:

-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.

-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.

-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Usual Adult Dose for Burns – External

Solution: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:

-Discontinue treatment if allergic manifestations occur.

-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.

-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.

-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:

-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.

-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.

-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Renal Dose Adjustments

Acute renal failure: Use with caution.

Dose Adjustments

If acidosis occurs and becomes difficult to control, especially in those with pulmonary dysfunction, discontinue therapy for 24 to 48 hours while continuing fluid therapy.

Other Comments

Administration advice:

-Solution: Following reconstitution, filter through a 0.22-micron filter prior to use.

Reconstitution/preparation techniques:

-Solution: Empty entire contents of the premeasured 50 g packet into a suitable container containing 1000 mL of sterile water for irrigation or 0.9% sodium chloride irrigation; mix until completely dissolved.

Monitoring:

-Dermatologic: Monitor sites for bacterial growth.

What is the dose of Mafenide for a child?

Usual Pediatric Dose for Bacterial Infection

Solution:

3 months or older: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:

-Discontinue treatment if allergic manifestations occur.

-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.

-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.

-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:

-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.

-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.

-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Usual Pediatric Dose for Burns – External

Solution:

3 months or older: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:

-Discontinue treatment if allergic manifestations occur.

-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.

-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.

-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:

-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.

-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.

-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Precautions

Solution: Safety and efficacy have not been established in patients younger than 3 months.

How is Mafenide available?

Mafenide is available in the following dosage forms and strengths:

  • Topical cream,
  • Topical powder for reconstitution,
  • Compounding powder.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Mafenide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 10, 2018 | Last Modified: August 10, 2018