Generic Name: Lyrica Brand Name(s): Generics only. No brands available.

Uses

What is Lyrica® (pregabalin) used for?

Lyrica® is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Lyrica® also affects chemicals in the brain that send pain signals across the nervous system.

Lyrica® is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia, or neuropathic pain associated with spinal cord injury.

Lyrica® may also be used for other purposes not listed in this medication guide.

How should I take Lyrica® (pregabalin)?

Take Lyrica® exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take Lyrica® with or without food.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not change your dose of Lyrica® without your doctor’s advice. Tell your doctor if the medication does not seem to work as well in treating your condition.

How do I store Lyrica® (pregabalin)?

Lyrica® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Lyrica® in the bathroom or the freezer. There may be different brands of Lyrica® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Lyrica® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Lyrica® (pregabalin)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Lyrica® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You may have thoughts about suicide while taking Lyrica®. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor if you have any problems with your vision while taking Lyrica. If you are taking Lyrica® to prevent seizures, keep taking it even if you feel fine. You may have an increase in seizures if you stop taking Lyrica®. Follow your doctor’s instructions.

Do not stop using Lyrica® without first talking to your doctor, even if you feel fine. You may have increased seizures or withdrawal symptoms such as headache, sleep problems, nausea, and diarrhea. Ask your doctor how to avoid withdrawal symptoms when you stop using Lyrica®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Lyrica® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Lyrica®. Lyrica® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Lyrica® (pregabalin)?

Less serious side effects may include:

  • Dizziness
  • Drowsiness
  • Loss of balance or coordination
  • Problems with memory or concentration
  • Breast swelling
  • Tremors
  • Dry mouth
  • Constipation

Call your doctor at once if you have any of these serious side effects while using Lyrica®:

  • Muscle pain, weakness, or tenderness (especially if you also have a fever and feel tired)
  • Vision problems
  • Easy bruising or bleeding
  • Swelling in your hands or feet
  • Rapid weight gain

Report any new or worsening symptoms to your doctor, such as:

  • Mood or behavior changes
  • Anxiety
  • Panic attacks
  • Trouble sleeping
  • Impulsive
  • Irritable
  • Agitated
  • Hostile
  • Aggressive
  • Restless
  • Hyperactive (mentally or physically)
  • More depressed
  • Have thoughts about suicide or hurting yourself

Get emergency medical help if you have any of these signs of an allergic reaction to Lyrica®: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Lyrica® (pregabalin)?

Lyrica® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Rosiglitazone (Avandia, Avandamet, Avandaryl)
  • Heart or blood pressure medication such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others

Does food or alcohol interact with Lyrica® (pregabalin)?

Lyrica® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Lyrica® (pregabalin)?

Lyrica® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Congestive heart failure
  • Diabetes (unless you are taking Lyrica to treat diabetic neuropathy)
  • Kidney disease (or if you are on dialysis)
  • A bleeding disorder
  • Low levels of platelets in your blood
  • A history of depression or suicidal thoughts
  • A history of drug or alcohol addiction
  • A severe allergic reaction

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Lyrica® (pregabalin).

What is the dose of Lyrica® (pregabalin) for an adult?

Neuropathic Pain Associated with Diabetic Peripheral Neuropathy

The maximum recommended dose is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min.

Begin dosing at 50 mg three times a day (150 mg/day).

The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Postherpetic Neuralgia

The recommended dose is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min.

Begin dosing at 75 mg two times a day, or 50 mg three times a day (150 mg/day).

The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Adjunctive Therapy for Adult Patients with Partial Onset Seizures

Lyrica® at doses of 150 to 600 mg/day has been shown to be effective as adjunctive therapy in the treatment of partial onset seizures in adults.

Both the efficacy and adverse event profiles of Lyrica® have been shown to be dose-related. Administer the total daily dose in two or three divided doses.

In general, it is recommended that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day).

Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day.

Management of Fibromyalgia

The recommended dose for fibromyalgia is 300 to 450 mg/day. Begin dosing at 75 mg two times a day (150 mg/day).

The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day).

Neuropathic Pain Associated with Spinal Cord Injury

The recommended dose range for the treatment of neuropathic pain associated with spinal cord injury is 150 to 600 mg/day.

The recommended starting dose is 75 mg two times a day (150 mg/day).

The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Patients who do not experience sufficient pain relief after 2 to 3 weeks of treatment with 150 mg two times a day and who tolerate Lyrica® may be treated with up to 300 mg two times a day.

What is the dose of Lyrica® (pregabalin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Lyrica® (pregabalin) available?

Lyrica® is available in the following dosage forms and strengths:

  • Capsule, oral solution pregabalin 25mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Lyrica®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

 

Sources

Review Date: July 13, 2017 | Last Modified: July 13, 2017

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