By Medically reviewed by hellodoktor

Generic Name: Lubiprostone Brand Name(s): Generics only. No brands available.


What is Lubiprostone used for?

This medication is used to treat certain types of constipation (chronic idiopathic constipation, irritable bowel syndrome with constipation). Chronic idiopathic constipation has an unknown cause and is not due to diet, other diseases, or drugs.

Lubiprostone is also used to treat constipation caused by narcotic (opiate-type) medications in people with ongoing pain due to medical conditions other than cancer.

This medication may improve symptoms such as bloating and abdominal discomfort, improve stool texture, lessen the need to strain, and decrease the feeling of not completely relieving oneself. Lubiprostone belongs to a class of drugs known as chloride channel activators. It works by increasing the amount of fluid within your intestines, making the passage of stool easier.

How should I take Lubiprostone?

Take this medication by mouth with food and water as directed by your doctor, usually twice daily. Swallow the medication whole. Do not break or chew the medication.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly in order to get the most benefit from it. Remember to take it at the same times each day.

You should talk to your doctor regularly about whether you still need this treatment.

Inform your doctor if your condition persists or worsens.

How do I store Lubiprostone?

Lubiprostone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Lubiprostone in the bathroom or the freezer. There may be different brands of Lubiprostone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Lubiprostone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Lubiprostone?

Before taking lubiprostone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain stomach/intestinal problems (blockage, severe diarrhea), liver disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk, but it may have undesirable effects (such as causing diarrhea) on a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Lubiprostone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Lubiprostone. Lubiprostone is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Lubiprostone?

Nausea, diarrhea, gas, vomiting, dry mouth, runny nose, cough, fever, headache, joint/back pain, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: swelling of arms/legs, mental/mood changes.

This medication may cause low blood pressure and possibly fainting. Diarrhea and vomiting may increase the risk of theseside effects. Stop taking this medication and tell your doctor right away if any of these serious side effects occur: fainting, dizziness, severe diarrhea/vomiting.

Lubiprostone may rarely cause trouble breathing and chest tightness within 30 to 60 minutes after the first dose. This reaction is usually not serious and generally goes away within 3 hours. It may happen again with other doses. However, you may not be able to tell this reaction apart from a rare, severe reaction that also causes trouble breathing and/or chest pain. Therefore, get medical help right away if you develop any trouble breathing or chest tightness/discomfort/pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Lubiprostone?

Lubiprostone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Lubiprostone?

Lubiprostone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Lubiprostone?

Lubiprostone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Lubiprostone.

What is the dose of Lubiprostone for an adult?

Usual Adult Dose for Constipation – Chronic

24 mcg orally 2 times a day

Comments: The effectiveness of this drug in the treatment of opioid-induced constipation in patients taking diphenylheptane opioids (e.g., methadone) has not been established.

Use: Treatment of chronic idiopathic constipation and of opioid-induced constipation in adults with chronic non-cancer pain.

Usual Adult Dose for Irritable Bowel Syndrome

8 mcg orally 2 times a day

Use: Treatment of irritable bowel syndrome with constipation (IBS-C) in women age 18 years and older.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Patients with Chronic Idiopathic Constipation or Opioid-Induced Constipation:

Initial Dose:

-Mild Liver Dysfunction (Child-Pugh A): Dose adjustment not required.

-Moderate Liver Dysfunction (Child-Pugh B): 16 mcg orally 2 times a day

-Severe Liver Dysfunction (Child-Pugh C): 8 mcg orally 2 times a day

Patients with IBS-C:

-Mild (Child-Pugh A) and Moderate (Child-Pugh B) Liver Dysfunction: Dose adjustment not required.

-Severe Liver Dysfunction (Child-Pugh C): 8 mcg orally once a day

Maintenance Dose: If the initial dose is tolerated and an adequate response has not been obtained after an appropriate interval, escalate dose to full dosing with appropriate monitoring of patient response.


No adjustment recommended.

Other Comments

Administration Advice:

-Take doses with food and water.

-Swallow drug capsules whole; do not break apart or chew them.

Storage Requirements:

-Store at 25 degrees Celsius (77 degrees Fahrenheit); excursions permitted to 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit).

-Store in the original container to protect from light and moisture.

-Use drug within 4 weeks after opening the original container.


-Following 4 weeks of twice-daily treatment, withdrawal of this drug did not result in a rebound effect.


-Assessment of need for continued therapy (periodically)

Patient Advice:

-Contact your healthcare provider immediately if you experience severe nausea, diarrhea, or dyspnea during treatment.

What is the dose of Lubiprostone for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Lubiprostone available?

Lubiprostone is available in the following dosage forms and strengths:

  • Oral Capsule

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Lubiprostone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 23, 2018 | Last Modified: September 12, 2019