Generic Name: Loratadine + Pseudoephedrine Brand Name(s): Generics only. No brands available.

Uses

What is Loratadine + Pseudoephedrine used for?

Loratadine is an antihistamine which provides relief of seasonal allergy symptoms such as watery and itching eyes, runny nose, and sneezing. Pseudoephedrine is a decongestant which helps relieve a stuffy nose, promotes sinus draining, and improves breathing.

This medication is not recommended for use in children under 12 years of age due to the high amount of pseudoephedrine.

How should I take Loratadine + Pseudoephedrine?

Take this medication by mouth as directed by your doctor, usually twice daily (every 12 hours) with a full glass of water.

Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Do not increase your dose or take this more often than directed.

Do not take this medication for several days before allergy testing since test results can be affected. Consult your doctor or pharmacist for more information.

How do I store Loratadine + Pseudoephedrine?

Loratadine + Pseudoephedrine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Loratadine + Pseudoephedrine in the bathroom or the freezer. There may be different brands of Loratadine + Pseudoephedrine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Loratadine + Pseudoephedrine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Loratadine + Pseudoephedrine?

Before taking loratadine with pseudoephedrine, tell your doctor or pharmacist if you are allergic to it; or to desloratadine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (narrow angle type), severe difficulty urinating (urinary retention), severe high blood pressure, severe heart/blood vessel disease (coronary artery disease), liver disease, experienced serious side effects with decongestants (irregular heart rhythm).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, problems urinating (e.g., enlarged prostate), high blood pressure, diabetes, heart problems (e.g., ischemic heart disease), thyroid problems (hyperthyroidism), glaucoma (open angle type).

Limit alcoholic beverages, as it may intensify drug side effects. (See also Side Effects.)

Older adults may be more sensitive to the side effects of this drug, especially fast/irregular heartbeat, dizziness, problems urinating, trouble sleeping, or confusion. Dizziness, trouble sleeping, and confusion can increase the risk of falling.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and is unlikely to cause harm to a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Loratadine + Pseudoephedrine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Loratadine + Pseudoephedrine. Loratadine + Pseudoephedrine is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Loratadine + Pseudoephedrine?

Dry mouth, mild stomach upset, trouble sleeping, dizziness, headache, nervousness, loss of appetite, or thirst may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: fast/irregular heartbeat, uncontrolled shaking or tremor.

Tell your doctor right away if any of these unlikely but serious side effects occur: seizures, mental/mood changes (such as confusion), difficulty urinating.

This medication does not usually cause drowsiness when used at recommended doses and under normal circumstances. However, this drug may make you dizzy; therefore use caution engaging in activities that require alertness such as driving or using machinery.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Loratadine + Pseudoephedrine?

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: adrenalin-like drugs (e.g., ephedrine, methylphenidate), certain high blood pressure drugs (e.g., guanethidine, methyldopa, reserpine, beta-blockers such as propranolol), herbal products containing ephedra.

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain additional decongestants that could increase your risk for side effects. Ask your pharmacist about the safe use of those products.

Loratadine is very similar to desloratadine. Do not use medications containing desloratadine while using loratadine.

This medication may interfere with certain laboratory tests (including allergy skin testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Loratadine + Pseudoephedrine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Loratadine + Pseudoephedrine?

Loratadine + Pseudoephedrine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Loratadine + Pseudoephedrine?

Loratadine + Pseudoephedrine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Loratadine + Pseudoephedrine.

What is the dose of Loratadine + Pseudoephedrine for an adult?

Usual Adult Dose for Allergic Rhinitis

1 tablet (5 mg-120 mg) orally twice a day

-or-

1 tablet (10 mg-240 mg) orally once daily.

Usual Adult Dose for Nasal Congestion

1 tablet (5 mg-120 mg) orally twice a day

-or-

1 tablet (10 mg-240 mg) orally once daily.

Renal Dose Adjustments

1 tablet (5 mg-120 mg) orally once daily

-or-

1 tablet (10 mg-240 mg) orally every other day.

Liver Dose Adjustments

The manufacturer recommends that tablets containing loratadine in fixed combination with pseudoephedrine sulfate generally not be used in patients with hepatic impairment.

Dose Adjustments

Pseudoephedrine is eliminated by the kidney and may accumulate in patients with renal dysfunction. Patients with renal dysfunction should be monitored for signs and symptoms of toxicity when using pseudoephedrine.

Dialysis

Pseudoephedrine is partially removed by hemodialysis, therefore doses should be given following dialysis sessions.

What is the dose of Loratadine + Pseudoephedrine for a child?

Usual Pediatric Dose for Allergic Rhinitis

over 12 years:

1 tablet (5 mg-120 mg) orally twice a day

-or-

1 tablet (10 mg-240 mg) orally once daily.

Usual Pediatric Dose for Nasal Congestion

over 12 years:

1 tablet (5 mg-120 mg) orally twice a day

-or-

1 tablet (10 mg-240 mg) orally once daily.

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

How is Loratadine + Pseudoephedrine available?

Loratadine + Pseudoephedrine is available in the following dosage forms and strengths:

  • Oral tablet, extended release

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Loratadine + Pseudoephedrine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 17, 2018 | Last Modified: March 17, 2018

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