Lixisenatide

By Medically reviewed by hellodoktor

Generic Name: Lixisenatide Brand Name(s): Lixisenatide and Lixisenatide. Avability: Rx Pregnancy Category: N

Uses

What is Lixisenatide used for?

Lixisenatide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Lixisenatide is similar to a natural hormone in your body (incretin). It works by causing insulin release in response to high sugar levels (such as after a meal) and decreasing the amount of sugar your liver makes.

Lixisenatide is not a substitute for insulin if you require insulin treatment.

How should I take Lixisenatide?

Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin.

Inject this medication under the skin in the thigh, abdomen, or upper arm as directed by your doctor, usually once daily within 1 hour before the first meal of the day.

Lixisenatide can slow down or decrease the absorption of other drugs such as birth control pills, antibiotics, or acetaminophen. Take other medications at least 1 hour before using this medication. Take birth control pills at least 1 hour before or 11 hours after using this medication. If you must take these other medications with food, take them with a meal or snack when you are not using this product. Ask your doctor or pharmacist if you have any questions about when to take your medications.

Use this medication regularly to get the most benefit from it. To help you remember, use it with the same meal each day.

Do not share your pen device with another person, even if the needle is changed. You may give other people a serious infection, or get a serious infection from them. Learn how to store and discard medical supplies safely.

Tell your doctor if your condition does not get better or if it gets worse (your blood sugar is too high or too low).

How do I store Lixisenatide?

Storing unopened (not in use) lixisenatide: Refrigerate and protect from light. Take the injection pen out of the refrigerator and allow it to reach room temperature before using.Do not freeze lixisenatide, and throw away the medicine if it has been frozen.

Storing opened (in use) lixisenatide: Store at room temperature with the pen cap attached, and use within 14 days. Do not store the injection pen with a needle attached.

There may be different brands of Lixisenatide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Lixisenatide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Lixisenatide?

Before using lixisenatide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: disease of the pancreas (pancreatitis), kidney disease, stomach/intestinal disorders (such as gastroparesis, digestion problems).

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Lixisenatide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Lixisenatide. Lixisenatide is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Lixisenatide?

Nausea, vomiting, diarrhea, constipation, stomach upset, dizziness, or pain/itching/swelling at injection site may occur. Nausea usually lessens as you continue to use lixisenatide. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Vomiting/diarrhea that doesn’t stop may result in a serious loss of body water (dehydration). Contact your doctor promptly if you notice any symptoms of dehydration, such as unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine).

Lixisenatide has rarely caused a very serious (possibly fatal) disease of the pancreas (pancreatitis). Get medical help right away if you develop symptoms of pancreatitis, including: nausea/vomiting that doesn’t stop, severe stomach/abdominal pain.

This medication does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications, or if you do not consume enough calories from food, or if you do unusually heavy exercise. Talk with your doctor or pharmacist about whether the dose of your other diabetes medication(s) needs to be lowered. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Lixisenatide?

Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are not affected by these drugs.

Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed by your doctor. Tell your doctor about the results and of any symptoms of high or low blood sugar. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Lixisenatide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Lixisenatide?

Lixisenatide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Limit alcohol while using this medication because it can increase your risk of developing low blood sugar.

What health conditions may interact with Lixisenatide?

Lixisenatide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Lixisenatide.

What is the dose of Lixisenatide for an adult?

Usual Adult Dose for Diabetes Type 2

Initial dose: 10 mcg subcutaneously once a day for 14 days

Maintenance dose: Increase to 20 mcg subcutaneously once a day on day 15, and thereafter

Renal Dose Adjustments

-Mild to severe renal impairment (eGFR 15 to 89 mL/min/1.73 m2): Use caution; no dose adjustment required; however closely monitor for gastrointestinal adverse reactions and changes in renal function

-ESRD (eGFR less than 15 mL/min/1.73 m2): Use is not recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Not recommended in patients with severe gastroparesis

-When added to sulfonylurea or basal insulin; dose reduction of sulfonylurea or basal insulin is recommended to avoid hypoglycemia.

What is the dose of Lixisenatide for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Lixisenatide available?

Lixisenatide is available in the following dosage forms and strengths:

  • Subcutaneous kit,
  • Subcutaneous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Lixisenatide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 14, 2018 | Last Modified: September 12, 2019

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