By Medically reviewed by hellodoktor

Generic Name: Liotrix Brand Name(s): Generics only. No brands available.


What is Liotrix used for?

Liotrix is used to treat an underactive thyroid (hypothyroidism). It replaces or provides more of a certain natural substance (thyroid hormone) that is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery. Having enough thyroid hormone in your bloodstream is important for maintaining normal mental and physical activity. In children, having enough thyroid hormone is important for normal mental and physical development.

This medication is also used to treat other types of thyroid disorders (e.g., certain types of goiters, thyroid cancer).

This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.

How should I take Liotrix?

Take this medication by mouth, usually once a day on an empty stomach, 30 minutes to 1 hour before breakfast, or as directed by your doctor.

Dosage is based on your medical condition, laboratory test results, and response to treatment. For children, the dosage is also based on age. Your doctor will usually start you on a low dose and slowly increase your dose as needed.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Do not stop taking this medication without first consulting with your doctor. Thyroid replacement treatment is usually taken for life.

Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heartbeat, or sensitivity to cold. Tell your doctor if your condition worsens or persists after several weeks of taking this medication.

How do I store Liotrix?

Liotrix is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Liotrix that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Liotrix down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Liotrix?

Before taking liotrix, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: increased thyroid hormones (thyrotoxicosis), a heart attack (acute myocardial infarction), adrenal gland problem (e.g., uncorrected adrenal insufficiency).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., coronary artery disease, irregular heartbeat), high blood pressure, diabetes, other hormone disorders (e.g., decreased pituitary hormone).

If you have diabetes, this medication may increase your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar, such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects on the heart caused by high thyroid hormone level.

Current information shows that this drug may be used during pregnancy. Tell your doctor if you are pregnant or if you become pregnant because your dose may need to be adjusted.

Small amounts of this medication pass into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Liotrix during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Liotrix. Liotrix is pregnancy risk category A according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Liotrix?

Some hair loss may occur during the first few months of starting this drug. This effect is usually temporary as your body adjusts to this medication. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious effects of high thyroid hormone levels occur: diarrhea, bone pain, headache, mental/mood changes (e.g., nervousness, mood swings), shaking (tremor), sensitivity to heat, increased sweating, tiredness.

Seek immediate medical attention if any of these rare but very serious effects of high thyroid hormone levels occur: chest pain, fast/pounding/irregular heartbeat, seizures, swelling of the ankles/feet.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Liotrix?

Some products that may interact with this drug include: androgens/anabolic steroids, beta blockers (e.g., propranolol), “blood thinners” (e.g., warfarin), corticosteroids (e.g., dexamethasone), cytokines (e.g., interferon-alpha, interleukin-2), digoxin, drugs affecting liver enzymes that remove liotrix from your body (such as phenobarbital, rifamycins including rifabutin, certain anti-seizure medicines including phenytoin), drugs that can decrease thyroid hormone levels (e.g., amiodarone, medications containing iodide/iodine, lithium), estrogen-containing products (including birth control pills), growth hormones, medications for depression (e.g., maprotiline, tricyclic antidepressants such as amitriptyline, SSRIs such as sertraline).

Certain medications (cholestyramine, colestipol, antacids, sucralfate, simethicone, iron, sodium polystyrene sulfonate, calcium carbonate, orlistat) can decrease the amount of liotrix that is absorbed by your body . If you are taking any of these drugs, separate them from this medication by at least 4 hours.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients such as decongestants or caffeine that could increase your heart rate or blood pressure. Ask your pharmacist about using those products safely.

Liotrix may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Liotrix?

Liotrix may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Liotrix?

Liotrix may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Liotrix.

What is the dose of Liotrix for an adult?

Usual Adult Dose for Hypothyroidism

Initial dose: Levothyroxine 25 mcg-liothyronine 6.25 mcg orally once a day; increase in increments of 1 tablet of levothyroxine 12.5 mcg-liothyronine 3.1 mcg every 2 to 3 weeks

-A lower initial dose is recommended in patients with long-standing myxedema: Levothyroxine 12.5 mcg-liothyronine 3.1 mcg orally once a day is recommended, particularly if cardiovascular impairment is suspected; extreme caution should be used.

Maintenance dose: Most patients require levothyroxine 50 mcg-liothyronine 12.5 mcg (1 tablet) to levothyroxine 100 mcg-liothyronine 25 mcg (1 tablet) orally per day


-Failure to respond to doses of levothyroxine 150 mcg-liothyronine 37.5 mcg (1 tablet) suggests lack of compliance or malabsorption.

Uses: For use as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis

Dose Adjustments

Patients with cardiac disease/angina pectoris and the elderly:

-Initiate at lower doses; i.e., levothyroxine 12.5 mcg-liothyronine 3.1 mcg or levothyroxine 25 mcg-liothyronine 6.25 mcg

-When in such patients a euthyroid state can only be reached at the expense of aggravation of cardiovascular disease, thyroid hormone dosage should be reduced.

Other Comments

Administration advice:

-Therapy is usually initiated at lower doses and titrated based on cardiovascular status of patient.

-Therapy should be initiated immediately upon diagnosis and maintained for life, unless transient hypothyroidism is suspected, in which case therapy can be interrupted for 2 to 8 weeks after 3 years of age to reassess condition.

-Cessation of therapy may be justified in patients who have maintained a normal TSH during those 2 to 8 weeks.

-Adequate therapy usually results in normal TSH and T4 levels after 2 to 3 weeks of therapy.

-Readjustment of thyroid hormone dose should occur within the first 4 weeks of therapy, following proper clinical and laboratory evaluations, including serum levels of T4, bound and free, and TSH.

Storage requirements:

-Store at 2C to 8C (36F to 46F).

-Store in a tight, light resistant container.


-Thyroid hormones should be used cautiously in patients in whom there is strong suspicion of thyroid gland autonomy, in view of the fact that exogenous hormone effects will be additive to the endogenous source.


-Cardiovascular: Measure prothrombin time frequently if concomitant oral anticoagulant therapy is being used.

-Endocrine: Periodically obtain thyroid function tests; monitor glucose levels in patients with diabetes mellitus or insipidus

Patient advice:

-Immediately seek treatment if signs/symptoms of thyroid hormone toxicity occur at any point during treatment, including chest pain, increased pulse rate, palpitations, excessive sweating, heat intolerance, nervousness, or any other unusual event.

What is the dose of Liotrix for a child?

Usual Pediatric Dose for Hypothyroidism

0 to 6 months: Levothyroxine 12.5 mcg-liothyronine 3.1 mcg to levothyroxine 25 mcg-liothyronine 6.25 mcg orally per day

6 to 12 months: Levothyroxine 25 mcg-liothyronine 6.25 mcg to levothyroxine 37.5 mcg-liothyronine 9.35 mcg orally per day

1 to 5 years: Levothyroxine 37.5 mcg-liothyronine 9.35 mcg to levothyroxine 50 mcg-liothyronine 12.5 mcg orally per day

6 to 12 years: Levothyroxine 50 mcg-liothyronine 12.5 mcg to levothyroxine 75 mcg-liothyronine 18.75 mcg orally per day

Over 12 years: Doses over levothyroxine 75 mcg-liothyronine 18.75 mcg orally per day


-Infants with congenital hypothyroidism should begin therapy with full doses as soon as the diagnosis is made.

-Routine determination of thyroid status, including serum T4 and/or thyroid stimulating hormone (TSH) are recommended in all patients, especially neonates, in view of the deleterious effects of thyroid deficiency on growth and development.

Use: For the treatment of congenital hypothyroidism

How is Liotrix available?

Liotrix is available in the following dosage forms and strengths:

  • Oral Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Liotrix, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 17, 2018 | Last Modified: September 12, 2019

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