Generic Name: Levofloxacin Brand Name(s): Generics only. No brands available.

Uses

What is levofloxacin used for?

Levofloxacin is commonly used to treat a wide variety of bacterial infections. Levofloxacin belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria.

This medication will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness

How should I take levofloxacin?

Drinking extra fluids while you are taking levofloxacin is recommended. Check with your doctor for instructions.

Levofloxacin is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using levofloxacin at home, a health care provider will teach you how to use it. Be sure you understand how to use levofloxacin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use levofloxacin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Levofloxacin works best if it is used at the same time each day.

To clear up your infection completely, use levofloxacin for the full course of treatment. Keep using it even if you feel better in a few days.

How do I store levofloxacin?

Levofloxacin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store levofloxacin in the bathroom or the freezer. There may be different brands of levofloxacin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush levofloxacin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using levofloxacin?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of levofloxacin or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have a history of severe or persistent diarrhea, skin sensitivity to the sun, diabetes or high blood sugar, low blood sugar, low blood potassium levels, chest pain, angina, heart problems (e.g., enlarged heart, heart failure), a heart attack, irregular heartbeat, or if you have a family member with a history of irregular heartbeat (e.g., QT prolongation).
  • You have a stomach infection, brain or nervous system problems, myasthenia gravis, increased pressure in the brain, brain blood vessel problems, or a history of seizures.
  • You have a history of bone, joint, or tendon problems; rheumatoid arthritis; liver problems; kidney problems or decreased kidney function; myasthenia gravis; nerve problems; or a heart, kidney, or lung transplant.
  • You participate in strenuous physical work or exercise.
  • You take any medicines that may increase the risk of seizures. Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of seizures.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using levofloxacin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking levofloxacin. Levofloxacin is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from levofloxacin?

Less serious side effects may include:

  • Mild diarrhea, constipation, vomiting
  • Sleep problems (insomnia)
  • Mild headache or dizziness
  • Vaginal itching or discharge

Stop using levofloxacin and call your doctor at once if you have a serious side effect such as:

  • Chest pain and severe dizziness, fainting, fast or pounding heartbeats
  • Sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints
  • Diarrhea that is watery or bloody
  • Confusion, hallucinations, depression, tremors, feeling restless or anxious, unusual thoughts or behavior, insomnia, nightmares, seizure (convulsions)
  • Severe headache, ringing in your ears, nausea, vision problems, pain behind your eyes
  • Pale skin, fever, weakness, easy bruising or bleeding
  • Nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Urinating less than usual or not at all
  • Numbness, burning pain, or tingly feeling in your hands or feet
  • The first sign of any skin rash, no matter how mild
  • Severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with levofloxacin?

Levofloxacin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Antiarrhythmics (e.g., amiodarone, dofetilide, procainamide, quinidine, sotalol), arsenic, asenapine, bepridil, chloroquine, cisapride, citalopram, clozapine, crizotinib, dolasetron, droperidol, halofantrine, haloperidol, iloperidone, imidazoles (e.g., fluconazole, ketoconazole), macrolides (e.g., erythromycin), maprotiline, methadone, nilotinib, ondansetron, paliperidone, pentamidine, phenothiazines (e.g., chlorpromazine), pimozide, quetiapine, romidepsin, tacrolimus, telithromycin, tetrabenazine, toremifene, tricyclic antidepressants (e.g., nortriptyline), tyrosine kinase inhibitors (e.g., sunitinib), vandetanib, or ziprasidone because the risk of serious heart problems, including irregular heartbeat, may be increased.
  • Insulin or oral diabetes medicines (e.g., glyburide) because the risk of high or low blood sugar may be increased.
  • Corticosteroids (e.g., prednisone) because the risk of tendon problems may be increased.
  • Anticoagulants (e.g., warfarin) because the risk of bleeding may be increased.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) or theophylline because the risk of serious side effects, including seizures, may be increased.

Does food or alcohol interact with levofloxacin?

Levofloxacin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with levofloxacin?

Levofloxacin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using levofloxacin.

What is the dose of levofloxacin for an adult?

Usual Adult Dose for Nosocomial Pneumonia:

750 mg orally or IV every 24 hours for 7 to 14 days.

Usual Adult Dose for Pneumonia:

750 mg orally or IV every 24 hours for 5 days.

Usual Adult Dose for Sinusitis:

500 mg orally or IV every 24 hours for 10 to 14 days or 750 mg orally or IV every 24 hours for 5 days.

Usual Adult Dose for Bronchitis:

500 mg orally or IV once a day for 7 days.

Usual Adult Dose for Skin or Soft Tissue Infection:

  • Uncomplicated: 500 mg orally or IV once a day for 7 to 10 days.
  • Complicated: 750 mg orally or IV once a day for 7 to 14 days.

Usual Adult Dose for Prostatitis:

500 mg orally or IV every 24 hours for 28 days

Usual Adult Dose for Urinary Tract Infection:

Complicated:

Due to Enterococcus faecalis, Enterobacter cloacae, E coli, K pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa: 250 mg orally or IV once a day for 10 days

Due to E coli, K pneumoniae, or P mirabilis: 750 mg orally or IV once a day for 5 days

Uncomplicated: 250 mg orally or IV once a day for 3 days.

Usual Adult Dose for Pyelonephritis.

Acute:

Due to Escherichia coli: 250 mg orally or IV once a day for 10 days

Due to E coli (including cases with concurrent bacteremia): 750 mg orally or IV once a day for 5 days

Usual Adult Dose for Cystitis:

250 mg orally or IV once a day for 3 days

Usual Adult Dose for Anthrax Prophylaxis:

Prophylaxis postexposure to inhalational Bacillus anthracis: 500 mg orally or IV once a day for 60 days after exposure

Usual Adult Dose for Plague:

For treatment of plague (including pneumonic and septicemic plague) and prophylaxis for plague: 500 mg orally or IV once a day for 10 to 14 days/

Drug administration should begin as soon as possible after suspected or confirmed exposure to Yersinia pestis. Higher doses (750 mg orally or IV once a day) can be used for treatment of plague if clinically indicated.

Usual Adult Dose for Plague Prophylaxis:

For treatment of plague (including pneumonic and septicemic plague) and prophylaxis for plague: 500 mg orally or IV once a day for 10 to 14 days. Drug administration should begin as soon as possible after suspected or confirmed exposure to Yersinia pestis. Higher doses (750 mg orally or IV once a day) can be used for treatment of plague if clinically indicated.

Usual Adult Dose for Inhalation Bacillus anthracis.

Mass casualty treatment: 500 mg orally or IV once a day for 60 days

Usual Adult Dose for Tuberculosis – Active:

500 to 1000 mg orally or IV once a day

Usual Adult Dose for Nongonococcal Urethritis:

CDC recommendations: 500 mg orally once a day for 7 days

Usual Adult Dose for Chlamydia Infection:

CDC recommendations: 500 mg orally once a day for 7 days

Usual Adult Dose for Pelvic Inflammatory Disease:

Mild to moderately severe acute PID: 500 mg orally once a day for 14 days

Usual Adult Dose for Epididymitis – Sexually Transmitted:

CDC recommendations: 500 mg orally once a day for 10 days

What is the dose of levofloxacin for a child?

Usual Pediatric Dose for Anthrax Prophylaxis

Prophylaxis postexposure to inhalational B anthracis:

6 months or older:

Less than 50 kg: 8 mg/kg orally or IV every 12 hours for 60 days; not to exceed 250 mg per dose

50 kg or more: 500 mg orally or IV every 24 hours for 60 days

Usual Pediatric Dose for Plague

For treatment of plague (including pneumonic and septicemic plague) and prophylaxis for plague:

6 months or older:

Less than 50 kg: 8 mg/kg orally or IV every 12 hours for 10 to 14 days; not to exceed 250 mg per dose

50 kg or more: 500 mg orally or IV every 24 hours for 10 to 14 days

Usual Pediatric Dose for Plague Prophylaxis

For treatment of plague (including pneumonic and septicemic plague) and prophylaxis for plague:

6 months or older:

Less than 50 kg: 8 mg/kg orally or IV every 12 hours for 10 to 14 days; not to exceed 250 mg per dose

50 kg or more: 500 mg orally or IV every 24 hours for 10 to 14 days

How is levofloxacin available?

Levofloxacin is available in the following dosage forms and strengths:

  • Solution, Oral: 25 mg/mL.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of levofloxacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: July 31, 2017 | Last Modified: July 31, 2017

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