Levobunolol

By Medically reviewed by hellodoktor

Generic Name: Levobunolol Brand Name(s): Generics only. No brands available.

Uses

What is Levobunolol used for?

This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Levobunolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.

How should I take Levobunolol?

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch, usually once or twice daily or as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed or if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before using the other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

How do I store Levobunolol?

Levobunolol is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Levobunolol in the bathroom or the freezer. There may be different brands of Levobunolol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Levobunolol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Levobunolol is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Levobunolol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Levobunolol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Levobunolol?

Before using levobunolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, metipranolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride, sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g., cardiogenic shock, severe heart failure).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e.g., cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis).

Before having surgery, tell your doctor or dentist that you are using this medication.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Levobunolol during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Levobunolol. Levobunolol is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Levobunolol?

Temporary burning/stinging of the eye, itchy/red eyes, headache, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, reduced feeling in eye, slow/irregular heartbeat, muscle weakness, hair loss, mental/mood changes, vision changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.

Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest pain, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Levobunolol?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, drugs for high blood pressure (e.g., clonidine, reserpine, oral beta blockers such as propranolol, calcium channel blockers such as diltiazem), epinephrine, fingolimod, phenothiazines (e.g., prochlorperazine).

Levobunolol may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Levobunolol?

Levobunolol may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Levobunolol?

Levobunolol may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Levobunolol.

What is the dose of Levobunolol for an adult?

Usual Adult Dose for Intraocular Hypertension

0.25% solution: One to two drops in the affected eye(s) twice a day

0.5% solution: One to two drops in the affected eye(s) once a day

Comments:

-In patients with more severe or uncontrolled glaucoma, the 0.5% solution can be administered twice a day.

-If intraocular pressure is not at a satisfactory level, concomitant therapy with dipivefrin and/or epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted.

-Patients should not use two or more topical ophthalmic beta-adrenergic blocking drugs concomitantly.

Use: Lowering intraocular pressure in patients with chronic open-angle glaucoma and intraocular hypertension

Usual Adult Dose for Glaucoma (Open Angle)

0.25% solution: One to two drops in the affected eye(s) twice a day

0.5% solution: One to two drops in the affected eye(s) once a day

Comments:

-In patients with more severe or uncontrolled glaucoma, the 0.5% solution can be administered twice a day.

-If intraocular pressure is not at a satisfactory level, concomitant therapy with dipivefrin and/or epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted.

-Patients should not use two or more topical ophthalmic beta-adrenergic blocking drugs concomitantly.

Use: Lowering intraocular pressure in patients with chronic open-angle glaucoma and intraocular hypertension

Other Comments

Storage requirements:

-Protect from light

-Do not store above 25 C (77 F)

Patient advice:

-The systemic absorption may be reduced when using nasolacrimal occlusion or closing the eyelids for 2 minutes.

What is the dose of Levobunolol for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Levobunolol available?

Levobunolol is available in the following dosage forms and strengths:

  • Ophthalmic solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Levobunolol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 17, 2018 | Last Modified: September 12, 2019

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