Generic Name: Lanthanum carbonate Brand Name(s): .

Uses

What is Lanthanum carbonate used for?

Lanthanum is used to lower high blood phosphate levels in people who are on dialysis due to severe kidney disease. Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced. Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and may decrease the risk of heart disease and strokes that can result from high phosphate levels.

Lanthanum is a natural mineral that works by binding to phosphate in the foods you eat. The phosphate then passes out of your body in your stool.

How should I take Lanthanum carbonate?

Take this medication by mouth as directed by your doctor, usually with or right after meals. Chew the tablets completely before swallowing to reduce the risk of stomach/abdominal side effects. You may crush the tablets to make it easier to chew them. Do not swallow the tablets whole. You do not need to swallow this medication with water.

Take this medication regularly to get the most benefit from it. The dosage is based on your medical condition, response to treatment, and laboratory test results.

Lanthanum may stop some medications from working well if you take them at the same time. Ask your pharmacist if you need to separate the time that you take your other medications from the time that you take lanthanum.

How do I store Lanthanum carbonate?

Lanthanum carbonate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Lanthanum carbonate in the bathroom or the freezer. There may be different brands of Lanthanum carbonate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Lanthanum carbonate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Lanthanum carbonate?

Before taking lanthanum, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal problems (such as ulcers, bowel blockage/surgery, cancer, constipation), diabetes.

Before having an X-ray of your stomach/abdomen, tell X-ray personnel that you are taking this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for children because it may affect the bones.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Lanthanum carbonate during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Lanthanum carbonate. Lanthanum carbonate is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Lanthanum carbonate?

Before taking lanthanum, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal problems (such as ulcers, bowel blockage/surgery, cancer, constipation), diabetes.

Before having an X-ray of your stomach/abdomen, tell X-ray personnel that you are taking this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for children because it may affect the bones.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Lanthanum carbonate?

Lanthanum may stop some medications from working well if you take them at the same time. Ask your pharmacist for details because you may need to separate the times you take lanthanum by at least 2 hours from the times you take the following medications, among others: mycophenolate, thyroid medications (such as levothyroxine), tetracycline antibiotics (such as doxycycline, tetracycline), drugs that interact with antacids.

Other medications (such as quinolone antibiotics including ciprofloxacin/levofloxacin) may require different separation time schedules. Talk with your doctor or pharmacist about how to schedule lanthanum and your other medications.

Lanthanum carbonate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Lanthanum carbonate?

Lanthanum carbonate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Lanthanum carbonate?

Lanthanum carbonate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Lanthanum carbonate.

What is the dose of Lanthanum carbonate for an adult?

Usual Adult Dose for Hyperphosphatemia of Renal Failure

Initial dose: 1500 mg orally daily; take in divided doses with meals

Titrate in increments of 750 mg/day every 2 to 3 weeks until an acceptable serum phosphate level is reached

Maximum dose: 4500 mg/day

Comments: Most patients will require daily doses between 1500 and 3000 mg to reduce plasma phosphate levels to less than 6 mg/dL.

Use: To reduce serum phosphate levels in patients with end stage renal disease.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dialysis

This drug is indicated for patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis; therefore, no dosage adjustment is recommended.

Other Comments

Administration advice:

-Take with or immediately after meals

-Tablets must be chewed completely before swallowing; may crush tablets prior to administration if needed

-Oral powder should be sprinkled on a small quantity of applesauce (or similar food) and consumed immediately; do not attempt to dissolve in liquid as powder is insoluble

General:

-Patients should adhere to recommended diets in order to control phosphate and fluid intake.

-Patients with poor dentition or those who have difficulty chewing tablets should use the oral powder to avoid the risk of serious gastrointestinal events.

Monitoring:

-Serum phosphate levels should be monitored as needed during dose titration and regularly thereafter.

-Thyroid stimulating hormone (TSH) levels should be checked in patients receiving thyroid hormone replacement.

-Hypocalcemia may develop in patients with renal dysfunction; periodic monitoring of serum calcium levels is recommended.

-Consider monitoring liver function in patients with marked reduction of bile flow.

Patient advice:

-Patients should be instructed as to proper way to take this medication to avoid risk of serious gastrointestinal adverse events.

-Gastrointestinal events are common with initiation of therapy; taking this medication with food will minimize events and with continued dosing they tend to lessen.

-Antacids, thyroid medications, and antibiotic medications may need to be taken 1 to 2 hours before or 2 to 4 hours after taking this medication; check with a health care professional for specific timing.

-Patients should let their physician know they are taking this drug prior to an abdominal X-ray.

What is the dose of Lanthanum carbonate for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Lanthanum carbonate available?

Lanthanum carbonate is available in the following dosage forms and strengths:

  • Oral tablet, chewable,
  • Oral powder for reconstitution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Lanthanum carbonate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 13, 2018 | Last Modified: March 13, 2018

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