Generic Name: Labetalol hydrochloride Brand Name(s): Generics only. No brands available.

Uses

What is labetalol hydrochloride used for?

Labetalol hydrochloride is commonly used for treatment hypertension (high blood pressure).

It may also be used for other purposes, ask your doctor for more information.

How should I take labetalol hydrochloride?

Labetalol hydrochloride is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using labetalol at home, a health care provider will teach you how to use it. Be sure you understand how to use labetalol. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use labetalol if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

How do I store labetalol hydrochloride?

Labetalol hydrochloride is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store labetalol hydrochloride in the bathroom or the freezer. There may be different brands of labetalol hydrochloride that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush labetalol hydrochloride down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using labetalol hydrochloride?

Before using this drug, there is some important information that you may notice:

  • You should not take labetalol hydrochloride if you are allergic to it.
  • Labetalol hydrochloride can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine.
  • If you need surgery, tell the surgeon ahead of time that you are using labetalol.
  • Your blood pressure will need to be checked often, and you may need frequent medical tests at your doctor’s office.
  • It is not known whether labetalol hydrochloride will harm an unborn baby.
  • Labetalol hydrochloride may cause heart or lung problems in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while taking labetalol.
  • Do not skip doses or stop taking labetalol hydrochloride without first talking to your doctor. Stopping suddenly may make your condition worse.
  • Labetalol hydrochloride can cause false results with certain lab tests of the urine. Tell any doctor who treats you that you are using labetalol.
  • Taking labetalol hydrochloride can make it harder for you to tell when your blood sugar is low. If you have diabetes, check your blood sugar regularly.
  • Keep using this medicine as directed, even if you feel well.High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
  • Labetalol hydrochloride is only part of a complete program of treatment for hypertension that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
  • Labetalol hydrochloride is not approved for use by anyone younger than 18 years old.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using labetalol hydrochloride during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking labetalol hydrochloride. Labetalol hydrochloride is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Labetalol hydrochloride can pass into breast milk in small amounts. Tell your doctor if you are breastfeeding.

Side effects

What side effects can occur from labetalol hydrochloride?

Common side effects may include:

  • Dizziness
  • Nausea
  • Upset stomach
  • Stuffy nose
  • Tingly feeling in your scalp

Call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Weak pulse
  • Fainting
  • Swelling
  • Rapid weight gain
  • Liver problems including nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Dangerously high blood pressure such as severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats

Get emergency medical help if you have signs of an allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with labetalol hydrochloride?

Labetalol hydrochloride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially if you are taking:

  • Cimetidine
  • Nitroglycerin
  • Insulin or oral diabetes medicine
  • An antidepressant such as amitriptyline, doxepin, desipramine, imipramine, nortriptyline, and others
  • A bronchodilator including albuterol, formoterol, salmeterol
  • Heart or blood pressure medicine such as amlodipine, digitalis, digoxin, verapamil

Does food or alcohol interact with labetalol hydrochloride?

Labetalol hydrochloride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with labetalol hydrochloride?

Labetalol hydrochloride may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure labetalol hydrochloride is safe for you, tell your doctor if you have:

  • Liver disease
  • Kidney disease
  • Pheochromocytoma (tumor of the adrenal gland)
  • Congestive heart failure
  • Diabetes
  • Allergies
  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • A serious heart condition such as second or third degree heart block, severe heart failure, or very slow heartbeats
  • A condition causing very low blood pressure

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using labetalol hydrochloride.

What is the dose of labetalol hydrochloride for an adult?

Oral:

Initial dose is 100 mg orally 2 times a day (alone or added to a diuretic regimen).

Titration: Dosage may be increased in increments of 100 mg orally 2 times a day, every 2 or 3 days.

Maintenance dose is 200 to 400 mg orally 2 times a day.

Maximum dose is Some patients may require 1200 to 2400 mg orally per day (titration increments should not exceed 200 mg orally 2 times a day).

Repeated IV injection

Immediately before the injection and at 5 and 10 minutes after injection, supine blood pressure should be measured to evaluate response.

Initial dose is 20 mg by slow IV injection over a 2-minute period.

Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg has been used.

The maximum effect usually occurs within 5 minutes of each injection.

Slow continuous IV infusion

The solution for injection should be prepared according to the manufacturer suggested guidelines for a resultant solution of 1 mg/ml or 2 mg/3 ml:

  • For 1 mg/ml, the diluted solution should be administered at a rate of 2 mL/min to deliver 2 mg/min.
  • For 2 mg/3 ml, the diluted solution should be administered at a rate of 3 mL/min to deliver approximately 2 mg/min.

Rate of infusion: The rate of infusion of the diluted solution may be adjusted according to the blood pressure response, at the discretion of the physician. To facilitate a desired rate of infusion, the diluted solution can be infused using a controlled administration mechanism, (e.g., graduated burette or mechanically driven infusion pump).

Since the half-life of this drug is 5 to 8 hours, steady-state blood levels (in the face of a constant rate of infusion) would not be reached during the usual infusion time period; the infusion should be continued until a satisfactory response is obtained and should then be stopped and the oral formulation should be started.

The effective IV dose is usually in the range of 50 to 200 mg.

A total dose of up to 300 mg IV may be required in some patients.

What is the dose of labetalol hydrochloride for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is labetalol hydrochloride available?

Labetalol hydrochloride is available in the following dosage forms and strengths:

  • Injection 5 mg/ml
  • Tablets 100 mg
  • Tablets 200 mg
  • Tablets 300 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of labetalol hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 1, 2017 | Last Modified: April 1, 2017