Keppra

By Medically reviewed by hellodoktor

Generic Name: Keppra Brand Name(s): Generics only. No brands available.

Uses

What is Keppra® (levetiracetam) used for?

Keppra® is an anti-epileptic drug, also called an anticonvulsant.

Keppra® is used to treat partial onset seizures in adults and children who are at least 4 years old.

Keppra® is also used to treat tonic-clonic seizures in adults and children who are at least 6 years old, and myoclonic seizures in adults and children who are at least 12 years old.

How should I take Keppra® (levetiracetam)?

Take Keppra® exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Keppra® is usually taken once every 12 to 24 hours. Take the medicine at the same time each day. You may take this medicine with or without food.

If a child is using this medicine, tell your doctor if the child has any changes in weight. Keppra® doses are based on weight in children, and any changes may affect your child’s dose.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

How do I store Keppra® (levetiracetam)?

Keppra® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Keppra® in the bathroom or the freezer. There may be different brands of Keppra® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Keppra® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Keppra® (levetiracetam)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Keppra® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Do not stop using Keppra® without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using Keppra® suddenly. You may need to use less and less before you stop the medication completely.

Some people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Wear a medical alert tag or carry an ID card stating that you take Keppra®. Any medical care provider who treats you should know that you take seizure medication.

Keppra® may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Do not start or stop taking Keppra® during pregnancy without your doctor’s advice. Having a seizure during pregnancy could harm both the mother and the baby. Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by using Keppra®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Keppra® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Keppra®. Keppra® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Keppra® (levetiracetam)?

Common side effects may include:

Get emergency medical help if you have signs of an allergic reaction like hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Keppra® (levetiracetam)?

Keppra® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Keppra® (levetiracetam)?

Keppra® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Keppra® (levetiracetam)?

Keppra® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure Keppra® is safe for you, tell your doctor if you have:

  • Kidney disease (or if you are on dialysis)
  • Depression or other mood problems
  • A history of mental illness or psychosis
  • A history of suicidal thoughts or actions

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Keppra® (levetiracetam).

What is the dose of Keppra® (levetiracetam) for an adult?

Myoclonic Seizures

Immediate-release: 500 mg IV/PO q12hr; may increase q2week by 500 mg/dose to recommended dose of 1500 mg q12hr.

Effectiveness of doses <3000 mg/day has not been adequately studied.

Partial Onset Seizure

Used as adjunctive therapy.

Immediate-release: 500 mg PO q12hr; may increase q2week by 500 mg/dose; not to exceed 3000 mg/day.

Extended-release: 1000 mg PO qDay; may increase q2week by 1000 mg/day; not to exceed 3000 mg/day.

IV: 500 mg q12hr; may increase q2week by 500 mg/dose; not to exceed 3000 mg/day.

Primary Generalized Tonic Clonic Seizures

Immediate-release: 500 mg IV/PO q12hr; may increase q2week by 500 mg/dose to recommended dose of 1500 mg q12hr.

Effectiveness of doses <3000 mg/day has not been adequately studied.

What is the dose of Keppra® (levetiracetam) for a child?

Partial Onset Seizures

Used as adjunctive therapy.

Immediate-release tablets

  • <1 month: Safety and efficacy not established.
  • 1-6 months: 7 mg/kg PO q12hr; increase by increments of 7 mg/kg q12hr q2weeks to recommended dose of 21 mg/kg q12hr.
  • 6 months-4 years: 10 mg/kg PO q12hr, increase in increments of 10 mg/kg q12hr q2weeks to recommended dose of 25 mg/kg q12hr.
  • 4-16 years: 10 mg/kg PO q12hr; increase q2week by 10 mg/kg/dose to 30 mg/kg q12hr.
  • >16 years: 500 mg PO q12hr, increase by 500 mg q12hr q2weeks to recommended dose of 1500 mg q12hr.
  • Daily dose is 3000 mg (1500 mg BID).

Extended-release tablets

  • <12 years: Safety and efficacy not established.
  • &12 years: 1000 mg PO qDay initially; may adjust dose by 1000 mg increments q2wk to a maximum of 3000 mg/day.

Primary Generalized Tonic-Clonic Seizures

<6 years: Safety and efficacy not established.

6-16 years: 10 mg/kg PO q12hr; increase q2week by 10 mg/kg/dose to recommended dose of 30 mg/kg q12hr; efficacy of doses <60 mg/kg/day not established.

>16 years: 500 mg PO q12hr, increase by 500 mg q12hr q2weeks to recommended dose of 1500 mg q12hr.

How is Keppra® (levetiracetam) available?

Keppra® is available in the following dosage forms and strengths:

  • Keppra® tablet, immediate-release 250mg, 500mg, 750mg, 1g
  • Keppra® tablet, extended-release 500mg, 750mg
  • Keppra® oral solution 100mg/mL
  • Keppra® injectable solution: 5mg/mL, 10mg/mL, 15mg/mL, 100mg/Ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Keppra®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: June 24, 2017 | Last Modified: September 12, 2019

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