Isosorbide mononitrate

By Medically reviewed by hellodoktor

Generic Name: Isosorbide mononitrate Brand Name(s): Generics only. No brands available.


What is isosorbide mononitrate used for?

Isosorbide mononitrate is commonly used for widens blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Isosorbide mononitrate is used to prevent angina attacks (chest pain). It will not treat an angina attack that has already begun.

Isosorbide mononitrate may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take isosorbide mononitrate?

Follow all directions on your prescription label.

Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take isosorbide mononitrate exactly as prescribed by your doctor.

Take isosorbide mononitrate by mouth with a full glass of water, do not chew or break it, swallow the whole the extended-release tablet/tablet. Should be taken on an empty stomach, in the morning right after you wake up.

Ask your health care provider any questions you may have about how to use this medication.

How do I store isosorbide mononitrate?

Isosorbide mononitrate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store isosorbide mononitrate in the bathroom or the freezer. There may be different brands of isosorbide mononitrate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush isosorbide mononitrate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using isosorbide mononitrate?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of isosorbide mononitrate or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from isosorbide mononitrate?

Isosorbide mononitrate may cause following side effects, such as:

  • Hypotension
  • Tachycardia
  • Flushing
  • Headache
  • Dizziness
  • Palpitation
  • Syncope
  • Confusion
  • Nausea
  • Vomiting
  • Restlessness
  • Weakness
  • Vertigo
  • Dry mouth
  • Chest pain
  • Back pain
  • Edema
  • Fatigue
  • Abdominal pain
  • Constipation
  • Diarrhea
  • Dyspepsia
  • Flatulence

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with isosorbide mononitrate?

Isosorbide mononitrate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • Taking isosorbide mononitrate with vasodilators medication may increase the hypotensive effects.
  • Taking isosorbide mononitrate with calcium channel blockers may lead to marked orthostatic hypotension.

Does food or alcohol interact with isosorbide mononitrate?

Isosorbide mononitrate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with isosorbide mononitrate?

Isosorbide mononitrate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • Congestive heart failure
  • Low blood pressure
  • Kidney disease (or if you are on dialysis)


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of isosorbide mononitrate for an adult?

For prevention of angina:

  • The extended-release tablets: Initial dose is 30 or 60 milligrams (mg) once a day; Your doctor may increase your dose as needed.
  • The tablets: 20 milligrams (mg) two times a day.

Your doctor may have prescribed a different dose.

What is the dose of isosorbide mononitrate for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is isosorbide mononitrate available?

Isosorbide mononitrate is available in the following dosage forms:

  • Extended Release Tablet 20 mg; 120 mg; 30 mg; 60 mg; 10 mg
  • Tablet 20 mg; 120 mg; 30 mg; 60 mg; 10 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of isosorbide mononitrate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: July 4, 2017 | Last Modified: September 13, 2019

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