Generic Name: Isoprenaline (isoproterenol) Brand Name(s): Generics only. No brands available.

Uses

What is isoprenaline (isoproterenol) used for?

Isoprenaline is a sympathomimetic. It works by relaxing blood vessels and helping the heart pump blood more efficiently. It helps to relax the airway during anesthesia to help you breathe more easily.

Isoprenaline is commonly used for treating certain heart problems (e.g., heart attack, congestive heart failure), blood vessel problems (e.g., shock), and certain types of irregular heartbeat (e.g., heart block). It is also used during anesthesia to treat airway constriction.

It may also be used for other conditions; ask your doctor for more information.

How should I take isoprenaline (isoproterenol)?

Isoprenaline is usually administered as an injection at your doctor’s office, hospital, or clinic. If you are using isoprenaline at home, carefully follow the injection procedures taught to you by your health care provider.

If isoprenaline contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.

Ask your health care provider any questions you may have about how to use isoproterenol.

How do I store isoprenaline (isoproterenol)?

There are two ways to store this drug:

Room temperature

Isoprenaline is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store isoprenaline in the bathroom or the freezer. There may be different brands of isoprenaline that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush isoprenaline down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Refrigerator

Isoprenaline is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of isoprenaline that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush isoprenaline down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using isoprenaline (isoproterenol)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in isoproterenol.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances (especially sulfites).
  • You are sensitive to sympathomimetic amines (e.g., phenylephrine).

There are some important safety information that you may notice:

  • Isoprenaline may cause blurred vision or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to isoproterenol. Using isoprenaline alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Some of these products contain sulfites, which can cause allergic reactions in certain individuals (e.g., asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using isoproterenol.
  • Lab tests, including blood pressure, blood gases, urine flow, heart rate, and heart function, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use isoprenaline with extreme caution in children. Safety and effectiveness have not been confirmed.

Is it safe during pregnancy or breastfeeding?

Pregnancy

It is unknown if isoprenaline can cause harm to the fetus. If you become pregnant while taking isoproterenol, discuss with your doctor the benefits and risks of using isoprenaline during pregnancy.

Breastfeeding

It is unknown if isoprenaline is excreted in breast milk. If you are or will be breastfeeding while you are using isoproterenol, check with your doctor or pharmacist to discuss the risks to your baby.

Side effects

What side effects can occur from isoprenaline (isoproterenol)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Dizziness
  • Flushing
  • Headache
  • Mild tremors
  • Nausea
  • Nervousness
  • Paleness
  • Sweating
  • Weakness

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Blurred vision
  • Chest pain
  • Fast or irregular heartbeat
  • Severe headache or dizziness
  • Wheezing

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with isoprenaline (isoproterenol)?

Isoprenaline may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Catechol-O-methyltransferase (COMT) inhibitors (e.g., tolcapone)
  • Droxidopa
  • Epinephrine
  • Inhaled anesthetics (e.g., halothane)

Does food or alcohol interact with isoprenaline (isoproterenol)?

Isoprenaline may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with isoprenaline (isoproterenol)?

Isoprenaline may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Asthma
  • Diabetes
  • Heart problems
  • Heart blood vessel problems (e.g., coronary artery disease)
  • An overactive thyroid
  • High blood pressure
  • Irregular heartbeat (e.g., tachyarrhythmia)
  • A fast heartbeat or heart block (caused by digoxin toxicity)

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using isoprenaline (isoproterenol).

What is the dose of isoprenaline (isoproterenol) for an adult?

Adams-stokes attacks, cardiac arrest, or heart block

The recommended dose is 0.02-0.06 mg (1-3 ml of a 1:50,000 dilution), initially, then doses of 0.01-0.2 mg.

The recommended dose is 5 mcg/min (1.25 ml of a 1:250,000 dilution), initially, then doses of 2-20 mcg/min based on patient’s response by IV infusion.

Shock

The recommended dose is 0.5-5 mcg/min (0.25-2.5 ml of a 1:250,000 dilution) by IV infusion.

Bronchospasm during anesthesia

The recommended dose is 0.01-0.02 mg IV repeat PRN.

What is the dose of isoprenaline (isoproterenol) for a child?

Adams-stokes attacks (off-label)

The initially dose is 0.1 mcg/kg/min IV infusion.

The usual dose is 0.1-1 mcg/kg/min IV infusion.

Cardiac arrest (Off-label)

The initially dose is 0.1 mcg/kg/min IV infusion.

The usual dose is 0.2 to 1 mcg/kg/min.

Heart Block (Off-label)

The initially dose is 0.1 mcg/kg/min IV infusion.

The usual dose is 0.3 to 1 mcg/kg/min IV infusion.

Postoperative cardiac patients with bradycardia

The recommended dose is 0.029 mcg/kg/min.

How is Isoprenaline (isoproterenol) available?

Isoprenaline is available in the following dosage forms and strengths:

  • Isoprenaline 0.2 mg/ml solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of isoprenaline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 17, 2017 | Last Modified: February 17, 2017

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