By Medically reviewed by hellodoktor

Generic Name: Invokana Brand Name(s): Invokana.


What is Invokana® (canagliflozin) used for?

Invokana® is an oral diabetes medicine that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Invokana® is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Invokana® is not for treating type 1 diabetes.

How should I take Invokana® (canagliflozin)?

Invokana® is usually taken once per day. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Invokana® is usually taken once per day, before the first meal of the day.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Drink plenty of liquids while you are taking Invokana®.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.

Invokana® is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

Invokana® can cause positive results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Invokana®.

How do I store Invokana® (canagliflozin)?

Invokana® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Invokana® in the bathroom or the freezer. There may be different brands of Invokana® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Invokana® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Invokana® (canagliflozin)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Invokana® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have severe kidney disease or if you are on dialysis.

It is not known whether Invokana® will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether canagliflozin passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine.

Invokana® is not approved for use by anyone younger than 18 years old.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Invokana® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Invokana®. Invokana® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Invokana® (canagliflozin)?

Common side effects may include:

  • Genital infections
  • Urinating more than usual

Call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Pain or burning when you urinate
  • Signs of a genital infection (penis or vagina), such as pain, burning, itching, redness, swelling, odor, or discharge
  • New pain, tenderness, sores, ulcers, or infections in your legs or feet
  • High potassium – nausea, slow or unusual heart rate, weakness, loss of movement
  • Ketoacidosis (too much acid in the blood) – nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing
  • Kidney problems – little or no urination
  • Swelling in your feet or ankles
  • Feeling tired or short of breath
  • Dehydration symptoms – feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin

Get emergency medical help if you have signs of an allergic reaction to Invokana®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may be more likely to have bone fractures (even after only a minor impact trauma) while you are taking Invokana®. Talk with your doctor about how to avoid the risk of fractures.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Invokana® (canagliflozin)?

Invokana® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • A diuretic or “water pill”
  • Digoxin, digitalis
  • Rifampin
  • Ritonavir
  • Seizure medication – phenobarbital, phenytoin

Does food or alcohol interact with Invokana® (canagliflozin)?

Invokana® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Invokana® (canagliflozin)?

Invokana® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Kidney disease
  • Liver disease
  • Bladder infections or other urination problems
  • Blood circulation problems
  • Nerve problems caused by diabetes
  • A diabetic foot ulcer or amputation
  • An electrolyte imbalance (such as high levels of potassium in your blood)
  • High cholesterol levels
  • Diabetic ketoacidosis (call your doctor for treatment with insulin)


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Invokana® (canagliflozin).

What is the dose of Invokana® (canagliflozin) for an adult?

Usual Adult Dose for Diabetes Type 2:

Initial dose: The recommended dose is 100 mg orally once daily.

Maximum dose: May increase to 300 mg orally once daily in patients with an eGFR of 60 mL/min/1.73 m2 or greater, tolerating therapy with 100 mg, and requiring additional glycemic control.

What is the dose of Invokana® (canagliflozin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Invokana® (canagliflozin) available?

Invokana® is available in the following dosage forms and strengths:

  • Tablet, film coated: canagliflozin 100mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Invokana®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: July 19, 2017 | Last Modified: September 13, 2019

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