By Medically reviewed by hellodoktor

Generic Name: Intrazoline Brand Name(s): Generics only. No brands available.


What is intrazoline used for?

Intrazoline is commonly used to treat many kinds of bacterial infections, including severe or life-threatening forms, involving the lung, bone, joint, stomach, blood, heart valve and urinary tract. Intrazoline will not treat a viral infection such as the flu or a common cold.

Intrazoline may be used for other purposes, ask your doctor for more information.

How should I take intrazoline?

Intrazoline is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

Intrazoline must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Shake the mixture well just before you measure a dose. Do not use the medicine if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

How do I store intrazoline?

To unmixed intrazoline

Intrazoline is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store intrazoline in the bathroom or the freezer. There may be different brands of intrazoline that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush intrazoline down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

To mixed intrazoline

After mixing intrazoline with a diluent, you may store the mixture in the refrigerator and use it within 10 days. Do not freeze. Follow the storage directions on your medicine label.

You may store the mixture for up to 24 hours at room temperature.

Precautions & warnings

What should I know before using intrazoline?

Intrazoline can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using intrazoline.

You should not use intrazoline if:

  • You have ever had a severe allergic reaction to any type of cephalosporin antibiotic (Omnicef, Cefzil, Ceftin, Keflex, and others).
  • You are malnourished.
  • You are allergic to any type of penicillin.

Intrazoline is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

Intrazoline can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using intrazoline during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking intrazoline. Intrazoline is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from intrazoline?

Common side effects may include:

  • Stomach pain
  • Loss of appetite
  • Rectal itching
  • Vaginal itching or discharge

Call your doctor at once if you have:

  • Diarrhea (watery or bloody)
  • White patches or sores inside your mouth or on your lips
  • Swollen glands
  • Joint pain
  • General ill feeling
  • Seizure (convulsions)
  • Liver problems including upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Severe skin reaction including fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash (especially in the face or upper body)

Get emergency medical help if you have signs of an allergic reaction such as hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with intrazoline?

Intrazoline may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially if you have ever had a severe allergic reaction to cefazolin or any other cephalosporin antibiotic, such as:

  • Cefaclor (Raniclor)
  • Cefadroxil (Duricef)
  • Cefdinir (Omnicef)
  • Cefazolin (Ancef)
  • Cefditoren (Spectracef)
  • Cefpodoxime (Vantin)
  • Cefprozil (Cefzil)
  • Ceftibuten (Cedax)
  • Cefuroxime (Ceftin)
  • Cephalexin (Keflex)
  • Cephradine (Velosef)

Does food or alcohol interact with intrazoline?

Intrazoline may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with intrazoline?

Intrazoline may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • Kidney disease
  • Liver disease
  • A stomach or intestinal disorder such as colitis


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using intrazoline.

What is the dose of intrazoline for an adult?

Moderate to severe infections

The recommended dose is 0.5-1 g IV q6-8hr.

Mild infections with Gram-Positive Cocci

The recommended dose is 250-500 mg IV q8hr.

Mild to moderate cholecystitis

The recommended dose is 1-2 g IV q8hr for 4-7 days.

Uncomplicated urinary tract infection

The recommended dose is 1 g IV q12hr.

Preparation for surgery – prophylaxis against infection

Preoperatively: The recommended dose is 1-2 g IV/IM ≤60 minutes before procedure (may be repeated in 2-5 hours intraoperatively).

Postoperatively: The recommended dose is 0.5-1 g IV q6-8hr for 24 hours.

Surgical infection

Cardiac procedures, hysterectomy, oral or pharyngeal procedures, craniotomy, joint replacement, thoracic procedures, arterial procedures, amputation, traumatic wounds; high-risk esophageal, gastroduodenal, or biliary tract procedures: The recommended dose is 1-2 g IV.

Colorectal procedures: The recommended dose is 1-2 g IV plus metronidazole 0.5 g IV.

High-risk cesarean section, 2nd trimester abortion: The recommended dose is 1 g IV.

Ophthalmic procedures: The recommended dose is 100 mg subconjunctivally.


The recommended dose is 1 g IV/IM 30-60 minutes before procedure.

American Heart Association (AHA) guidelines: Endocarditis prophylaxis recommended only for high-risk patients.

Bacterial Keratitis (Off-label)

1 drop instilled into affected eye(s) q1-2hr; typically alternated every other hour with antibiotic providing gram-negative coverage (e.g., tobramycin).

Extemporaneous compounded fortified cefazolin 50 mg/ml.

Dilute 500 mg parenteral cefazolin powder in sterile water to form 10 ml solution.

Store refrigerated; preparation expires in 7 days.

Dosing Modifications

Renal impairment

  • CrCl 35-54 ml/min: Give full dose at intervals >8hr.
  • CrCl 10-35 ml/min: Give therapeutic dose q12hr.
  • CrCl ≤10 ml/min: Give therapeutic dose q24hr.

What is the dose of intrazoline for a child?

Infections with Gram-Positive Cocci

Neonates (<28 days)

  • <7 days: The recommended dose is 40 mg/kg/day IV/IM divided q12hr.
  • >7 days, <2 kg: The recommended dose is 40 mg/kg/day IV/IM divided q12hr.
  • >7 days, >2 kg: The recommended dose is 60 mg/kg/day IV/IM divided q8hr.

Infants & children

  • The recommended dose is 25-100 mg/kg/day IV/IM divided q6-8hr; not to exceed 6 g/day.

Endocarditis – prophylaxi

The recommended dose is 50 mg/kg IV/IM ≤30-60 minutes before procedure; not to exceed 1 g.

AHA guidelines: Endocarditis prophylaxis recommended only for high-risk patients.

Community-Acquired Pneumonia

>3 months and children: The recommended dose is 150 mg/kg/day IV/IM divided q8hr (moderate to severe infections, methicillin susceptible S. Aureus preferred.

How is intrazoline available?

Intrazoline is available in the following dosage forms and strengths:

  • Intrazoline injection, cefazoline sodium 1g

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of intrazoline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 1, 2017 | Last Modified: September 12, 2019

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