Generic Name: Interferon Gamma-1B Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Interferon Gamma-1B used for?

Interferon Gamma-1B is used to reduce the frequency and severity of serious infections due to chronic granulomatous disease, a disorder that runs in families. This drug is often used along with antibiotics to help prevent these serious infections.

This medication is also used to slow the worsening of malignant osteopetrosis, another disorder that runs in families, that affects bones, nerves, and blood.

This medication is the same as a protein that your body naturally produces (interferon). In the body, it is thought to work by affecting cell function/growth and the body’s natural defenses (immune system) in many ways. Adding more interferon may help your body fight off serious infections.

How should I take Interferon Gamma-1B?

This medication is given by injection under the skin as directed by your doctor, usually 3 times weekly (e.g., Monday, Wednesday, and Friday). This medication is best used in the evening before bedtime to reduce side effects.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Do not shake the solution. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

It is important to change the location of the injection site with each dose to avoid problem areas under the skin. Therefore, choose a different injection site with each dose. The thighs and upper arms are recommended sites for the injection. Do not inject into skin that is irritated, sore, or infected.

The dosage is based on your body size, medical condition, and response to treatment. Do not change the dose or how often you use this medication without your doctor’s approval. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each evening that you have a scheduled dose.

How do I store Interferon Gamma-1B?

Interferon Gamma-1B is best stored in the refrigerator. To prevent drug damage, do not freeze. You may take the medicine out of the refrigerator and allow it to reach room temperature before injecting your dose.

Do not leave the medicine at room temperature for longer than 12 hours. Throw the medicine if it has been at room temperature for more than 12 hours. Do not put it back in the refrigerator.

There may be different brands of Interferon Gamma-1B that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.                         You should not flush Interferon Gamma-1B down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Interferon Gamma-1B?

Before using interferon, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as dry natural rubber/latex found in the packaging), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., angina, irregular heartbeat, congestive heart failure), liver disease, seizure disorder, blood cell disorders (e.g., anemia, neutropenia, thrombocytopenia).

Do not have immunizations/vaccinations without the consent of your doctor.

Children, especially those younger than 1 year, may be at greater risk for effects on the liver while using this drug. The manufacturer recommends regular laboratory tests (liver function tests), especially in children younger than 1 year.

This medication is not recommended for use during pregnancy. Consult your doctor for more details.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Interferon Gamma-1B during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Interferon Gamma-1B. Interferon Gamma-1B is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

 

Side effects

What side effects can occur from Interferon Gamma-1B?

Injection site reactions (pain/swelling/redness), diarrhea, upset stomach, nausea, or vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Flu-like symptoms such as headache, tiredness, fever, chills, and muscle aches may occur, especially when you first start this medication. These symptoms usually last about 1 day after the injection and improve or go away after a few months of continued use. You can reduce these side effects by injecting this medicine at bedtime and using a fever reducer/pain reliever such as acetaminophen before or after each dose. Consult your doctor or pharmacist for more information.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: lightheadedness, fainting, mental/mood changes (e.g., confusion, depression), shaking (tremors), trouble walking, slow/fast/irregular heartbeat, shortness of breath, swelling of the ankles/feet, increasing tiredness, joint pain, butterfly-shaped rash on the face, easy bleeding/bruising, persistent nausea/vomiting, signs of infection (e.g., fever, persistent sore throat), stomach/abdominal pain, black/tarry stools, dark urine, signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin.

Get medical help right away if any of these rare but very serious side effects occur: chest/jaw/left arm pain, weakness on one side of the body, slurred speech, sudden vision changes, seizures, pain/redness/swelling of the arms/legs, calf pain/swelling that is warm to the touch, coughing up blood.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Interferon Gamma-1B?

Some products that may interact with this drug include: drugs that may affect your immune system (e.g., cancer chemotherapy, prednisone, cyclosporine), hydroxyurea, theophyllines (e.g., aminophylline, theophylline).

Interferon Gamma-1B may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Interferon Gamma-1B?

Interferon Gamma-1B may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you tired or cause mental changes. Alcohol or marijuana can make you more tired or cause mental changes. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Interferon Gamma-1B?

Interferon Gamma-1B may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Interferon Gamma-1B.

What is the dose of Interferon Gamma-1B for an adult?

Usual Adult Dose for Osteopetrosis

BSA: greater than 0.5 m2

50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2

1.5 mcg/kg/dose subcutaneously three times weekly.

Usual Adult Dose for Chronic Granulomatous Disease

BSA: greater than 0.5 m2

50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2

1.5 mcg/kg/dose subcutaneously three times weekly.

Usual Adult Dose for Idiopathic Pulmonary Fibrosis

Study (n = 9)

200 mcg subcutaneously three times weekly (in combination with prednisolone 7.5 mg/day) for 12 months.

Usual Adult Dose for Cutaneous T-cell Lymphoma

Case study (Granulomatous slack skin)

2,000,000 units IV daily for 14 days.

Dose Adjustments

Decrease dose by 50% if severe reactions occur or discontinue therapy until adverse reaction abates.

What is the dose of Interferon Gamma-1B for a child?

Usual Pediatric Dose for Chronic Granulomatous Disease

Greater than or equal to 1 year old:

BSA: greater than 0.5 m2

50 mcg/m2 (1 million intl units/m2) subcutaneously three times weekly.

BSA: less than or equal to 0.5 m2

1.5 mcg/kg/dose subcutaneously three times weekly

How is Interferon Gamma-1B available?

Interferon Gamma-1B is available in the following dosage forms and strengths:

  • Subcutaneous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Interferon Gamma-1B, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 13, 2018 | Last Modified: November 13, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.