What is indinavir sulfate used for?
Indinavir sulfate is an HIV protease inhibitor. It works by blocking the growth of HIV.
Indinavir sulfate is commonly used for treating HIV infection in combination with certain other medicines.
How should I take indinavir sulfate?
Use indinavir sulfate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take indinavir sulfate by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take indinavir sulfate with water. You may also take it with other liquids such as skim or nonfat milk, juice, coffee, or tea.
Drinking extra fluids while you are taking indinavir sulfate is recommended. You should drink at least 1.5l of water a day unless otherwise directed by your doctor.
Take indinavir sulfate on a regular schedule to get the most benefit from it. Taking indinavir sulfate at the same time each day will help you remember to take it.
Continue to take indinavir sulfate even if you feel well. Do not miss any doses.
Ask your health care provider any questions you may have about how to use indinavir sulfate.
How do I store indinavir sulfate?
Indinavir sulfate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store indinavir sulfate in the bathroom or the freezer. There may be different brands of indinavir sulfate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush indinavir sulfate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using indinavir sulfate?
Before using indinavir sulfate, tell your doctor if:
- You are allergic to any ingredient in indinavir sulfate.
- You are taking sildenafil for pulmonary arterial hypertension (PAH).
- You take colchicine and also have kidney or liver problems.
- You are pregnant, planning to become pregnant, or are breastfeeding.
- You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
- You have allergies to medicines, foods, or other substances.
If you take didanosine, ask your doctor or pharmacist how to take it with indinavir sulfate.
Large amounts of garlic may decrease the effectiveness of indinavir sulfate. Talk with your doctor before including garlic in your diet.
Tell your doctor or dentist that you take indinavir sulfate before you receive any medical or dental care, emergency care, or surgery.
Indinavir sulfate may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use indinavir sulfate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Indinavir sulfate is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
Indinavir sulfate does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (e.g., condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking indinavir sulfate, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
Indinavir sulfate may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (e.g., fever, sore throat, weakness, cough, shortness of breath) after you start indinavir sulfate.
Changes in body fat (e.g., an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking indinavir sulfate. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
Indinavir sulfate may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
Diabetes patients: Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Hemophilia patients: Some people with hemophilia have developed increased bleeding while taking protease inhibitors, such as indinavir sulfate. Report all bleeding episodes to your doctor.
Hormonal birth control (e.g., birth control pills) may not work as well while you are using indinavir sulfate. To prevent pregnancy, use an extra form of birth control (e.g., condoms).
Lab tests, including liver function, cholesterol, complete blood cell counts, and CD4 counts, may be performed while you use indinavir sulfate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Caution is advised when using indinavir sulfate in children; they may be more sensitive to its effects, especially kidney stones.
Is it safe during pregnancy or breastfeeding?
There isn’t enough information about the safety of using indinavir sulfate during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking indinavir sulfate.
What side effects can occur from indinavir sulfate?
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:
- Bad taste in the mouth
- Mild stomach pain or upset
Seek medical attention right away if any of these severe side effects occur:
- Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
- Back, flank, or side pain
- Bloody or cloudy urine
- Change in the amount of urine produced
- Changes in appetite
- Chest, jaw, or arm pain
- Dark urine
- Ingrown toenails
- Joint pain
- Loss of appetite
- Numbness of the mouth
- One-sided numbness or weakness
- Pain while urinating
- Pale stools
- Red, swollen, blistered, or peeling skin
- Severe or persistent stomach pain or upset
- Shortness of breath
- Speech problems
- Sudden, unusual sweating
- Swelling of the stomach
- Unusual hair loss
- Unusual paleness
- Unusual tiredness or weakness
- Unusually dry skin
- Vision changes
- Yellowing of the skin or eyes
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with indinavir sulfate?
Indinavir sulfate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Products that may interact with your drug, such as:
- Oral midazolam
- John’s wort
Does food or alcohol interact with indinavir sulfate?
Indinavir sulfate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Indinavir sulfate?
Indinavir sulfate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
Especially if you have:
- Liver problems (e.g., cirrhosis)
- Kidney problems
- High blood sugar
- High cholesterol
- Kidney stones
- Urinary problems (e.g., white blood cells in the urine)
- Certain blood problems (e.g., hemophilia, hemolytic anemia)
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using indinavir sulfate.
What is the dose of indinavir sulfate for an adult?
The recommended dose is 800mg (usually two 400 mg capsules) orally, every 8 hours.
Reduce indinavir sulfate to 600mg every 8 h when administering delavirdine 400 mg 3 times a day.
Co-administration should be at least 1 h apart on an empty stomach.
Reduce indinavir sulfate to 600mg every 8 h when co-administered with itraconazole 200 mg twice daily.
Dosage reduction of indinavir sulfate to 600mg every 8 h is recommended when coadministering ketoconazole.
Reduce rifabutin to half the standard dose and increase dosage of indinavir sulfate to 1,000mg every 8 h when rifabutin and indinavir sulfate are co-administered.
Mild to moderate hepatic insufficiency caused by cirrhosis
The recommended dose is 600mg orally, every 8 hours.
What is the dose of indinavir sulfate for a child?
HIV-1 Infection (Off-label)
Neonates/infants: Safety and efficacy not established; should not be administered to neonates due to the risks associated with hyperbilirubinemia.
4-15 years (investigational): the recommended dose is 500 mg/m² PO q8hr.
How is indinavir sulfate available?
Indinavir sulfate is available in the following dosage forms and strengths:
- Capsules 100 mg
- Capsules 200 mg
- Capsules 400 mg
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of indinavir sulfate by more than 2 hours, do not take that dose. Take your next dose as scheduled.
If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of indinavir sulfate. Do not take 2 doses at once.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Review Date: April 5, 2017 | Last Modified: April 5, 2017
Indinavir sulfate. https://www.drugs.com/cdi/indinavir sulfate .html. Accessed December 8, 2016
Indinavir sulfate. https://www.drugs.com/ppa/indinavir-sulfate.html. Accessed December 8, 2016
Indinavir sulfate (Rx). http://reference.medscape.com/drug/crixivan-idv-indinavir sulfate -342620. Accessed December 8, 2016.