Ifosfamide

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Generic Name: Ifosfamide Brand Name(s): Generics only. No brands available.

Uses

What is ifosfamide used for?

Ifosfamide solution is an antineoplastic. It works by stopping the growth of certain cancers.

Ifosfamide is commonly used for treating certain types of cancer in combination with other medicines.

How should I take ifosfamide?

Ifosfamide solution is usually given as an injection at your doctor’s office, hospital, or clinic.

Do not use ifosfamide solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Drinking extra fluids while you are taking ifosfamide solution is recommended.

If your skin comes into contact with ifosfamide solution, wash the skin immediately with soap and water. If a mucous membrane (e.g., lips, tongue, nostrils) comes into contact with ifosfamide solution, rinse well with water.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Ask your health care provider any questions you may have about how to use ifosfamide solution.

How do I store ifosfamide?

Ifosfamide is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of ifosfamide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush ifosfamide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using ifosfamide?

Before using this drug, there is some important information that you may notice:

  • Ifosfamide solution may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use ifosfamide solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Empty your bladder regularly. Your doctor may recommend that you get up at least once during the night to urinate.
  • Ifosfamide solution may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding.
  • Ifosfamide solution may decrease your body’s ability to heal itself. To prevent wounds, avoid situations where bruising or injury may occur.
  • Ifosfamide solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • Check with your doctor before having vaccinations while you are using ifosfamide solution.
  • Lab tests, including kidney function, complete blood cell count, other blood tests, and urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ifosfamide solution with caution in the elderly; they may be more sensitive to its effects.
  • Use ifosfamide solution with extreme caution in children; safety and effectiveness have not been confirmed.

Also, do not use ifosfamide solution if:

  • You are allergic to any ingredient in ifosfamide solution.
  • You have severe bone marrow depression.
  • You are in your first 3 months of pregnancy.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using ifosfamide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking ifosfamide. Ifosfamide is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from ifosfamide?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Hair loss
  • Loss of appetite
  • Nausea

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Blood in the urine or dark urine
  • Coma
  • Confusion
  • Decrease in the amount of urine produced
  • Dizziness
  • Fever, chills, sore throat, or cough
  • Hallucinations
  • Irregular or absent menstrual periods
  • Joint pain
  • Mental or mood changes
  • Painful or frequent urination
  • Seizures
  • Shortness of breath
  • Sleepiness
  • Sores on the mouth or lips
  • Stomach pain
  • Unusual bruising or bleeding
  • Unusual fatigue
  • Vomiting
  • Yellowing of the skin or eyes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with ifosfamide?

Ifosfamide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, especially digoxin because its effectiveness may be decreased by ifosfamide solution

Does food or alcohol interact with ifosfamide?

Ifosfamide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with ifosfamide?

Ifosfamide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Liver or kidney problems
  • Bone marrow problems
  • Cancer
  • An infection
  • Chickenpox
  • Shingles
  • Radiation therapy

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using ifosfamide.

What is the dose of ifosfamide for an adult?

Germ cell testicular cancer

(Indicated in combination with other antineoplastic agents for third-line germ cell testicular cancer)

The recommended dose is 1.2 g/m²/day IV infusion over 30 minutes on days 1-5 q3-4wk or after recovering from hematologic toxicity (>100,000 cells/mm³ plateletes or ≥4,000 cells/mm³ WBC).

Off-label: The recommended dose is 2 g/m²/day IV infusion on days 1-3 (MAID regimen, for total dose of 6 g/m²); doses as high as 5 g/m² over 24hr via continuous IV infusion in combination with other antineoplastic agents used.

What is the dose of ifosfamide for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is ifosfamide available?

Ifosfamide is available in the following dosage forms and strengths:

  • Ifex injection 1g solution
  • Ifex injection 3g solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of ifosfamide solution, contact your doctor right away for dosing instructions.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 12, 2017 | Last Modified: March 12, 2017

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