Ibandronate

By Medically reviewed by hellodoktor

Generic Name: Ibandronate Brand Name(s): Ibandronate, Ibandronate and Ibandronate. Avability: Rx Pregnancy Category: C

Uses

What is Ibandronate used for?

Ibandronate is used to prevent and treat certain types of bone loss (osteoporosis). Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases after menopause, as you age, or if you take corticosteroid medications (such as prednisone) for long periods.

This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Ibandronate belongs to a class of medications called bisphosphonates.

How should I take Ibandronate?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Ibandronate tablets are taken once per month. Ibandronate injection is given into a vein through an IV once every 3 months.

Ibandronate tablets can be taken at home, but a healthcare provider must give the ibandronate injection.

Take the ibandronate tablet first thing in the morning, at least 60 minutes before you eat or drink anything or take any other medicine. Take the medicine on the same day each month and always first thing in the morning.

Take the ibandronate tablet with a full glass of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an ibandronate tablet. Swallow it whole.

For at least 60 minutes (1 full hour) after taking an ibandronate tablet:

  • Do not lie down or recline.
  • Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while using ibandronate. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using ibandronate.

Ibandronate is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor’s instructions very closely.

How do I store Ibandronate?

Ibandronate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Ibandronate in the bathroom or the freezer. There may be different brands of Ibandronate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Ibandronate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Ibandronate?

Before taking ibandronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate, etidronate, pamidronate, risedronate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Some people taking ibandronate may have serious jawbone problems. Your doctor should check your mouth before you start this medication. Tell your dentist that you are taking this medication before you have any dental work done. To help prevent jawbone problems, have regular dental exams and learn how to keep your teeth and gums healthy. If you have jaw pain, tell your doctor and dentist right away.

Before having surgery (especially dental procedures), tell your doctor and dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking ibandronate before your surgery. Ask for specific instructions about stopping or starting this medication.

Caution is advised if you are pregnant or planning to become pregnant in the future. This medication may stay in your body for many years. Its effects on an unborn baby are not known. Discuss the risks and benefits with your doctor before starting treatment with ibandronate.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Ibandronate during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Ibandronate. Ibandronate is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Ibandronate?

Stomach upset, diarrhea, pain in arms/legs, or mild flu-like symptoms (such as fatigue, muscle ache) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: increased or severe bone/joint/muscle pain, new or unusual hip/thigh/groin pain, jaw pain, vision changes.

This medication may rarely cause irritation and ulcers in your stomach or esophagus. Get medical help right away if any of these serious side effects occur: new/severe/worsening heartburn, chest pain, difficult or painful swallowing, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Ibandronate?

This medication may interfere with certain laboratory tests (bone-imaging agents), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Ibandronate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Ibandronate?

Ibandronate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Ibandronate?

Ibandronate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: esophagus problems (such as heartburn, narrowing of the esophagus, achalasia), low blood calcium levels (hypocalcemia), inability to sit upright or stand for 60 minutes, difficult or painful swallowing, stomach/intestinal disorders (such as ulcers), severe kidney disease.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Ibandronate.

What is the dose of Ibandronate for an adult?

Usual Adult Dose for Osteoporosis

Oral:

150 mg orally once a month on the same day each month

IV Injection:

3 mg by IV injection over 15 to 30 seconds every three months.

Comments:

-The IV injection should not be administered more frequently than once every 3 months.

-Obtain serum creatinine prior administration of each IV injection.

-Perform a routine oral examination prior administration of IV injection

Uses: Treatment and prevention of postmenopausal osteoporosis, to increase bone mineral density (BMD) and to reduce the incidence of vertebral fractures

Usual Adult Dose for Prevention of Osteoporosis

Oral:

150 mg orally once a month on the same day each month

IV Injection:

3 mg by IV injection over 15 to 30 seconds every three months.

Comments:

-The IV injection should not be administered more frequently than once every 3 months.

-Obtain serum creatinine prior administration of each IV injection.

-Perform a routine oral examination prior administration of IV injection

Uses: Treatment and prevention of postmenopausal osteoporosis, to increase bone mineral density (BMD) and to reduce the incidence of vertebral fractures

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min or more): No adjustment recommended.

Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

No adjustment recommended.

Other Comments

Administration advice:

Oral:

-To maximize absorption, take this drug at least 60 minutes before the first food or drink (other than water) of the day, or before taking any other medication or supplements, including calcium, antacids, or vitamins.

-Avoid the use of water with supplements, including mineral water (they may have higher concentration of calcium).

-Swallow the tablets whole with a full glass of plain water (6 to 8 ounces) in upright position to reduce the potential for esophageal irritation.

-Avoid lying down for 60 minutes after taking this drug.

-Tablets should not be chewed or sucked because of a potential for oropharyngeal ulceration.

-Food, drink (except plain water), and other medications should not be taken for at least 60 minutes after taking this drug.

IV Injection:

-This drug should be administered intravenously only by a health care professional.

-Care must be taken not to administer intra-arterially or paravenously as this could lead to tissue damage.

-Appropriate medical support and monitoring measures should be readily available when the injection is administered.

-If anaphylactic or other severe hypersensitivity/allergic reactions occur, discontinue the injection immediately and initiate appropriate treatment.

-Inspect the liquid in the vial for particulate matter and discoloration before administration; vial with particulate matter or discoloration should not be used.

-Discard any unused portion.

-Calcium-containing solutions or other intravenously administered drugs should not be mixed with this drug.

Recommendations for Calcium and Vitamin D Supplementation:

-Take supplemental calcium and vitamin D if dietary intake is inadequate.

-The use of calcium supplements within 60 minutes of administration of this drug should be avoided.

Administration Instructions for Missed Doses:

Oral:

-If the next scheduled dose is more than 7 days away, take one tablet in the morning after remembering.

-If the next scheduled dose is only 1 to 7 days away, wait until the next month’s scheduled day to take the tablet.

-Resume the next dose on its regular schedule.

IV Injectable:

-Administer the missed dose as soon as it can be re-scheduled.

-The next dose should be scheduled every 3 months from the date of the last injection.

Limitations of Use:

-The optimal duration of use has not been determined.

-All patients on bisphosphonate therapy should be reevaluated for continued therapy on a periodic basis.

-Patients at low-risk for fracture should consider drug discontinuation after 3 to 5 years of use.

-Reevaluate risk for fractures periodically after discontinuing therapy.

Monitoring:

-Metabolic: Serum calcium and symptoms of hypocalcemia

Patient advice:

-Patients should read the Medication Guide that comes with this drug before start treatment and with each refill.

-Report any side effect that bothers or that does not go away.

-Failure to follow administration instructions for this drug may increase the risk of esophageal adverse reactions.

-Discontinue this drug and seek medical attention if dysphagia, odynophagia, retrosternal pain or new or worsening heartburn develop.

What is the dose of Ibandronate for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Ibandronate available?

Ibandronate is available in the following dosage forms and strengths:

  • Oral tablet,
  • Intravenous kit,
  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Ibandronate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: August 14, 2018 | Last Modified: September 12, 2019

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