Generic Name: Hytrol Brand Name(s): Generics only. No brands available.

Uses

What is hytrol (enalapril) used for?

Hytrol is commonly used for treating or preventing high blood pressure (hypertension), symptomatic heart failure and diabetic nephropathy.

How should I take hytrol (enalapril)?

You may take enalapril with or without food. Swallow it whole. Do not chew or crush.

Take enalapril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

How do I store hytrol (enalapril)?

Hytrol is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store hytrol in the bathroom or the freezer. There may be different brands of hytrol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush hytrol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using hytrol (enalapril)?

You should not use enalapril if you are allergic to it.

Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested.

Enalapril can cause kidney problems. Call your doctor at once if you have swelling, rapid weight gain, little or no urinating, or if you feel short of breath. You may also need to avoid taking enalapril with aliskiren if you have kidney disease.

You may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual.

Do not use enalapril if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Enalapril can cause injury or death to an unborn baby.

If you have diabetes, do not use enalapril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

Enalapril can affect your heart or your electrolyte levels. Call your doctor if you have chest pain, pounding heartbeats or fluttering in your chest, a slow heart rate or weak pulse, a tingly feeling, muscle weakness, or muscle tightness or contraction.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using hytrol during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking hytrol. Hytrol is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Enalapril can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using this medicine.

Side effects

What side effects can occur from hytrol (enalapril)?

Common side effects may include:

  • Dizziness
  • Tired feeling
  • Cough
  • Feeling light-headed

Call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Pounding heartbeats or fluttering in your chest
  • High potassium including slow heart rate, weak pulse, muscle weakness, tingly feeling
  • Low white blood cell counts including sudden weakness or ill feeling, fever, chills, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing
  • Signs of a kidney problem including little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath

Get emergency medical help if you have any signs of an allergic reaction to enalapril such as hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with hytrol (enalapril)?

Hytrol may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that interact with this drug, such as:

  • Lithium
  • A diuretic or “water pill”
  • Gold injections to treat arthritis
  • Medicine to prevent organ transplant rejection – everolimus, sirolimus, temsirolimus
  • NSAIDs (nonsteroidal anti-inflammatory drugs) – aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others
  • ACE inhibitors, such as benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril

Does food or alcohol interact with hytrol (enalapril)?

Hytrol may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with hytrol (enalapril)?

Hytrol may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure enalapril is safe for you, tell your doctor if you have:

  • Kidney disease (or if you are on dialysis)
  • Liver disease
  • A history of blood clot or stroke
  • An electrolyte imbalance (such as high levels of potassium in your blood)
  • Heart disease or congestive heart failure (unless you are taking enalapril for this condition)
  • A history of angioedema

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using hytrol (enalapril).

What is the dose of hytrol (enalapril) for an adult?

Hypertension

Adult

  • The initial dose is 5 mg at bedtime.
  • The maintenance dose is 10-20 mg once daily increased up to 40 mg in 2 divided doses in severe HTN if needed.

Elderly

  • The initial dose is 2.5 mg/day.

Heart failure

Adult:

  • The initial dose is 2.5 mg/day.
  • The maintenance dose is 20 mg/day as single dose or in 2 divided doses, up to 40 mg/day in 2 divided doses.

Elderly:

  • The initial dose is 2.5 mg/day.

Renal impairment: 

CrCl ≤30 ml/min: The initial dose is 2.5 mg/day.

Reconstitution: 

Dilute in up to 50 ml of dextrose 5%, NaCl 0.9%, dextrose 5% and NaCl 0.9%, dextrose 5% in lactated Ringer’s.

Incompatibility: 

Enalaprilat is incompatible w/ amphotericin B and phenytoin Na.

What is the dose of hytrol (enalapril) for a child?

Hypertension

20 to <50 kg: The initial dose is 2.5 mg once daily, may increase up to max 20 mg once daily.

≥50 kg: The initial dose is 5 mg once daily, may increase up to max 40 mg once daily.

How is hytrol (enalapril) available?

Hytrol is available in the following dosage forms and strengths:

  • Capsule/ Tablet / 5mg / 10 units
  • Capsule/ Tablet / 2.5mg / 10 units
  • Capsule/ Tablet / 10mg / 10 units

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of hytrol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 18, 2017 | Last Modified: March 18, 2017

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