By Medically reviewed by hellodoktor

Generic Name: Hyposulfene Brand Name(s): Generics only. No brands available.


What is Hyposulfene (sodium thiosulfate) used for?

Hyposulfene may be used to lessen some of the side effects of cisplatin (a cancer medicine). It is also used with another medicine in the emergency treatment of cyanide poisoning.

Hyposulfene is to be administered only by or under the immediate supervision of your doctor.

How should I take Hyposulfene (sodium thiosulfate)?

Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended.

How do I store Hyposulfene (sodium thiosulfate)?

Hyposulfene is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Hyposulfene in the bathroom or the freezer. There may be different brands of Hyposulfene that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Hyposulfene down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Hyposulfene (sodium thiosulfate)?

Patients should be monitored for at least 24-48 hours after injection administration, for adequacy of oxygenation and perfusion and for recurrent signs and symptoms of cyanide toxicity. When possible, hemoglobin/hematocrit should be obtained when treatment is initiated.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Hyposulfene during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Hyposulfene. Hyposulfene is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Hyposulfene (sodium thiosulfate)?

If any of the following side effects occur while taking Hyposulfene, check with your doctor immediately:

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Hyposulfene (sodium thiosulfate)?

Hyposulfene may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Hyposulfene (sodium thiosulfate)?

Hyposulfene may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Hyposulfene (sodium thiosulfate)?

Hyposulfene may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Hyposulfene (sodium thiosulfate).

What is the dose of Hyposulfene (sodium thiosulfate) for an adult?

Hyposulfene tablet:

The recommended dose is 4-8 tablets a day, divide in to 2-3 times.

Slow intravenous use only:

The dose of sodium thiosulfate whether used alone or in combination with other cyanide antidotes is 12.5 grams given intravenously over approximately 10 minutes.

Patients should be closely monitored for 24 to 48 hours for symptoms of cyanide poisoning to reappear. In the event symptoms return, sodium thiosulfate administration should be repeated at one half the original dose.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

As a precautionary measure, a filter must be used for the withdrawal and administration of all lots of this product.

What is the dose of Hyposulfene (sodium thiosulfate) for a child?

Slow intravenous use only

The dosage for children is 7 grams per square meter of body surface area, with a maximum dose of 12.5 grams.

How is Hyposulfene (sodium thiosulfate) available?

Hyposulfene is available in the following dosage forms and strengths:

  • Hyposulfene 0.33 g x 60 Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Hyposulfene, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 12, 2017 | Last Modified: September 13, 2019

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