What is Humalog® (insulin lispro) used for?
Humalog® is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood.
Humalog® is used to improve blood sugar control in adults and children with diabetes mellitus.
Humalog® is used to treat type 2 diabetes in adults.
Humalog® is also used to treat type 1 diabetes in adults and children who are at least 3 years old.
How should I take Humalog® (insulin lispro)?
Use Humalog® exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Humalog® is injected under the skin, or into a vein through an IV. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
After using Humalog®, eat a meal within 15 minutes. If you did not use an injection before the meal, use the medicine right after you eat.
If you use this medicine with an insulin pump, do not mix or dilute Humalog® with any other insulin. Infusion pump tubing, catheters, and the needle location on your skin should be changed every 3 days. Change the medicine in the reservoir every 7 days.
Concentrated Humalog® (200 units/ml) must not be given with an insulin pump, or mixed with other insulins. Do not inject concentrated Humalog® into a vein.
If you use an injection pen, use only the injection pen that comes with Humalog®. A dose counter on the injection pen shows your dose in units. Do not convert your dose. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe or infusion pump.
Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.
Humalog® is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.
Keep this medicine in its original container protected from heat and light. Do not draw insulin from a vial into a syringe until you are ready to give an injection. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.
How do I store Humalog® (insulin lispro)?
Storing unopened (not in use) insulin lispro:
- Refrigerate and use until expiration date; or
- Store at room temperature and use within 28 days.
Storing opened (in use) Humalog®
- Store the vial in a refrigerator or at room temperature and use within 28 days.
- Store the cartridge or injection pen at room temperature (do not refrigerate) and use within 28 days. Do not store the injection pen with a needle attached.
- Do not use the medicine if it looks cloudy, has changed colors, or has any particles in it. Call your pharmacist for new medicine.
Precautions & warnings
What should I know before using Humalog® (insulin lispro)?
Before using this drug, tell your doctor if:
- You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
- You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
- You have allergy with any of active or inactive ingredients of Humalog® or other medications.
- You have any other illnesses, disorders, or medical conditions.
You should not use Humalog® if you are having an episode of hypoglycemia (low blood sugar).
Humalog® should not be given to a child younger than 3 years old. Humalog® should not be used to treat type 2 diabetes in a child of any age.
To make sure Humalog® is safe for you, tell your doctor if you have:
- Liver or kidney disease
- Low levels of potassium in your blood (hypokalemia)
Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.
Is it safe during pregnancy or breastfeeding?
There are no adequate studies in women for determining risk when using Humalog® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Humalog®. Humalog® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk
- B=No risk in some studies
- C=There may be some risk
- D=Positive evidence of risk
What side effects can occur from Humalog® (insulin lispro)?
Get emergency medical help if you have signs of insulin allergy to Humalog®: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.
Call your doctor at once if you have:
- Fluid retention–weight gain, swelling in your hands or feet, feeling short of breath
- Low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling
Common side effects may include:
- Low blood sugar
- Itching, mild skin rash
- Thickening or hollowing of the skin where you injected the medicine
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Humalog® (insulin lispro)?
Humalog® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Humalog® (insulin lispro)?
Humalog® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Humalog® (insulin lispro)?
Humalog® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Humalog® (insulin lispro).
What is the dose of Humalog® (insulin lispro) for an adult?
Individualize and adjust the dosage of Humalog® based on route of administration, the individual’s metabolic needs, blood glucose monitoring results and glycemic control goal.
Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness
What is the dose of Humalog® (insulin lispro) for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is Humalog® (insulin lispro) available?
Humalog® is available in the following dosage forms and strengths:
- Injection, solution: Insulin lispro 100[iU] in 1mL
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Humalog®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Review Date: September 3, 2017 | Last Modified: September 3, 2017