Generic Name: Holoxan Brand Name(s): Generics only. No brands available.


What is Holoxan® (ifosfamide) used for?

Holoxan®  is an antineoplastic. It works by stopping the growth of certain cancers.

Holoxan® is commonly used for treating certain types of cancer (such as breast cancer, lymph cancer, lung cancer) in combination with other medicines.

How should I take Holoxan® (ifosfamide)?

Your doctor will perform blood and urine tests to make sure you do not have conditions that would prevent you from safely using this medicine.

Ifosfamide is injected into a vein through an IV. A healthcare provider will give you this injection.

If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

Ifosfamide is given in a 21-day treatment cycle, but you will only need to take the medicine during the first 5 days of each cycle. Your doctor will determine how long to treat you with ifosfamide.

Drink plenty of liquids while you are taking ifosfamide.

How do I store Holoxan® (ifosfamide)?

Holoxan® is usually handled and stored by a health care provider. If you are using Holoxan® at home, store Holoxan® as directed by your pharmacist or health care provider. Keep Holoxan®, as well as needles and syringes, out of the reach of children and away from pets.

You should not flush Holoxan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Holoxan® (ifosfamide)?

Before using Holoxan®, tell your doctor if:

  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You have had radiation therapy or have received other chemotherapy medicines

Also, do not use Holoxan® if:

  • You are in your first 3 months of pregnancy.

When using this drug, you should notice that:

  • Holoxan® may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Holoxan® with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Empty your bladder regularly. Your doctor may recommend that you get up at least once during the night to urinate.
  • Holoxan® may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding.
  • Holoxan® may decrease your body’s ability to heal itself. To prevent wounds, avoid situations where bruising or injury may occur.
  • Holoxan® may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • Check with your doctor before having vaccinations while you are using Holoxan®.
  • Lab tests, including kidney function, complete blood cell count, other blood tests, and urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Holoxan® with caution in the elderly; they may be more sensitive to its effects.
  • Use Holoxan® with extreme caution in children; safety and effectiveness have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Holoxan®  during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Holoxan®. Holoxan® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Holoxan® (ifosfamide)?

Some side effects may occur when using this drug, including:

  • Hair loss
  • Loss of appetite
  • Nausea
  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Blood in the urine or dark urine
  • Coma
  • Confusion
  • Decrease in the amount of urine produced
  • Dizziness
  • Fever, chills, sore throat, or cough
  • Hallucinations
  • Irregular or absent menstrual periods
  • Joint pain
  • Mental or mood changes
  • Painful or frequent urination
  • Seizures
  • Shortness of breath
  • Sleepiness
  • Sores on the mouth or lips
  • Stomach pain
  • Unusual bruising or bleeding
  • Unusual fatigue
  • Vomiting
  • Yellowing of the skin or eyes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Holoxan® (ifosfamide)?

Holoxan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Digoxin

Does food or alcohol interact with Holoxan® (ifosfamide)?

Holoxan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Holoxan® (ifosfamide)?

Holoxan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Tell your doctor if you have:

  • Liver or kidney problems
  • Bone marrow problems
  • Cancer (that has spread to the bone marrow)
  • An infection
  • Chickenpox
  • Shingles


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Holoxan® (ifosfamide).

What is the dose of Holoxan® (ifosfamide) for an adult?

Testicular cancer

The recommended dose is 1.2 g/m2, diluted to 50 mg/ml IV over 30 minutes once a day with mesna (intravenous, oral, or continuous intravenous infusion) just before and 4 and 8 hours after each dose and aggressive (usually IV) hydration (2 to 4 L/day).
Ifosfamide is usually given for 5 days, with 5 day regimens repeated every 3 to 4 weeks, and after recovery from hematologic toxicity.

Cervical cancer

The recommended dose is 5,000 mg/m2 IV over 24 hours on day 2. Cycle repeated every 21 days.
Or, The recommended dose is 2,000 mg/m2 IV on days 1 through 3.Cycle repeated every 21 days.

What is the dose of Holoxan® (ifosfamide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Holoxan® (ifosfamide) available?

Holoxan® is available in the following dosage forms and strengths:

  • Intravenous powder for injection 1g, intravenous solution 1g

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Holoxan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: February 10, 2017 | Last Modified: February 10, 2017

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