By Medically reviewed by hellodoktor

Generic Name: Guanethidine Brand Name(s): Generics only. No brands available.

Know the basics

What is guanethidine used for?

Guanethidine drug (Abapressin®) is mainly used in the treatment for patients with:

  • Moderate and severe hypertension;
  • Renal hypertension as nephritis – kidney pool;
  • Starch degradation in the kidney and renal artery stenosis;
  • Drugs used to treat chronic open-angle glaucoma and eye diseases such as endocrine convex eyes, paralyzed eyes, eyelids slowly.

Guanethidine only be used for a small number of patients with hypertension that cannot tolerate or cannot be treated with other drugs.

How should I take guanethidine?

For orally taken form, you should:

  • Take guanethidine by mouth as directed by your doctor concerning: dose, schedule;
  • Read the label carefully before using guanethidine;
  • Consult your doctor for any information on the label that you do not clearly understand.

For injection form, you should:

  • Receive guanethidine injected by a dose calculated from your doctor;
  • Read the label carefully before using guanethidine hydrochloride;
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store guanethidine?

Guanethidine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store guanethidine in the bathroom or the freezer. There may be different brands of guanethidine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush guanethidine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using guanethidine?

Before using guanethidine, tell your doctor if you have:

  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals;
  • Pediatric;
  • Geriatric;
  • Used any other health conditions, drugs that have a risk of interaction with guanethidine.

Is it safe during pregnancy or breastfeeding?

Do not use this medication for pregnant women in the first 3 months and at least 2 weeks before birth or parturition, because the drug can cause intestinal obstruction in infant paralysis.

With therapeutic doses, guanethidine excretes in breast milk in very small amounts, so negligible effect on newborns.

Know the side effects

What side effects can occur from guanethidine?

As taking others medicines, taking guanethidine can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Posture hypotension or after practice (manifested as weakness, fatigue, dizziness, fainting);
  • Swelling and weight gain;
  • Congestive heart failure;
  • Increases peristalsis and severe diarrhea;
  • Inhibiting ejaculation, urinary night;
  • Tired;
  • Loss of appetite, nausea, vomiting, dry mouth;
  • Dermatitis;
  • Increase blood urea;
  • Bradycardia or atrioventricular block-button completely;
  • Depression;
  • Muscle pain, muscle vibration.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with guanethidine?

Guanethidine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

  • Clorpromazin®, phenothiazines derivatives, the tricyclic antidepressant, the oral contraceptive pill;
  • Antihypertensives;
  • Antiarrhythmic drugs and digitalis;
  • Monoamine oxidase inhibitors.

Does food or alcohol interact with guanethidine?

Guanethidine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with guanethidine?

Guanethidine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using guanethidine.

What is the dose of guanethidine for an adult?

Consult your doctor for information about the dose of guanethidine hydrochloride.

Recommended doses in some cases are listed below:

  • For ambulatory patients: the dose began, 10 mg / day, then increased from 10 to 12.5 mg / day; depending on the response of the patient, or the average dose of 25-50 mg / day.
  • Hospitalized patients: the initial dose, 25 – 50 mg, can be adjusted to 25 – 50 mg per day or every other day. The dose may be increased to 400 mg / day, if necessary.
  • Elderly: 5 mg once / day.
  • Use in ophthalmology: for the treatment of chronic open-angle glaucoma or endocrine-eyed, small 5% eye drops solution 1 or 2 drops in each eye, a small day 2 or 4 times.

What is the dose of guanethidine for a child?

Consult your doctor for information about the dose of guanethidine hydrochloride.

Recommended doses in some cases are listed below:

  • Children: 0.2 mg starting dose / kg / day once, after incrementing an initial amount equal doses, spaced about 1-2 weeks, up to a maximum of 3 mg / kg / day, if necessary.

How is guanethidine available?

Guanethidine is available in the following dosage forms and strengths:

  • Tablet: 5 mg, 10 mg, 25 mg, 50 mg;
  • Eyedrops: 5%.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of guanethidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: September 24, 2016 | Last Modified: September 13, 2019

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