Grepiflox

By Medically reviewed by hellodoktor

Generic Name: Grepiflox Brand Name(s): Generics only. No brands available.

Uses

What is grepiflox (levofloxacin) used for?

Grepiflox is commonly used for treating bacterial infections of the skin, sinuses, kidneys, bladder, or prostate. It is also used to treat infections that cause bronchitis or preumonia, and to prevent anthrax or plague in certain patients.

Grepiflox may be used for other purposes, ask your doctor for more information.

How should I take grepiflox (levofloxacin)?

Grepiflox is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using grepiflox at home, a health care provider will teach you how to use it. Be sure you understand how to use grepiflox. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Drinking extra fluids while you are taking grepiflox is recommended. Check with your doctor for instructions.

Do not use grepiflox if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Grepiflox works best if it is used at the same time each day.

To clear up your infection completely, use grepiflox for the full course of treatment. Keep using it even if you feel better in a few days.

How do I store grepiflox (levofloxacin)?

Grepiflox is usually handled and stored by a health care provider. If you are using grepiflox at home, store grepiflox as directed by your pharmacist or health care provider. Keep grepiflox out of the reach of children and away from pets.

Precautions & warnings

What should I know before using grepiflox (levofloxacin)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in grepiflox or to any other quinolone antibiotic (e.g., ciprofloxacin).
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Also, there is some important safety information that you may notice:

  • Grepiflox may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use grepiflox with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Nerve problems in the arms, hands, legs, or feet can happen in people taking grepiflox. These nerve problems can happen soon after grepiflox is started and may be permanent. Call your doctor right away if you have symptoms or nerve problems (e.g., not able to handle heat or cold; decreased sensation of touch; unusual burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet).
  • Grepiflox only works against bacteria; it does not treat viral infections (e.g., the common cold).
  • Be sure to use grepiflox for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of grepiflox may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Tell your doctor right away if you experience pain or swelling of a tendon or weakness or loss of use of a joint area. Rest the area and avoid exercise until further instruction from your doctor.
  • Grepiflox may cause you to become sunburned more easily. Avoid sunlamps or tanning booths, and try to limit your time in the sun. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Do not receive a live vaccine (e.g., typhoid) while you are taking grepiflox. Talk with your doctor before you receive any vaccine.
  • Diabetes patients: grepiflox may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Grepiflox may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using grepiflox.
  • Lab tests, including liver and kidney function and complete blood cell counts, may be performed while you use grepiflox. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use grepiflox with caution in the elderly; they may be more sensitive to its effects, especially tendon problems, irregular heartbeat, and liver problems.
  • Grepiflox should be used with extreme caution in children younger than 18 years old; they may be more sensitive to its effects, especially joint and tendon problems.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using grepiflox during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking grepiflox. Grepiflox is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Lactation:

Drug excreted in breast milk; not recommended.

Side effects

What side effects can occur from grepiflox (levofloxacin)?

Check with your doctor if any of these most common side effects persist or become bothersome:

  • Constipation
  • Diarrhea
  • Dizziness
  • Gas
  • Headache
  • Nausea
  • Trouble sleeping

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness)
  • Bloody or tarry stools
  • Chest pain
  • Decreased or painful urination
  • Fainting
  • Fast or irregular heartbeat
  • Fever, chills, persistent sore throat, or unusual cough
  • Hallucinations
  • Inability to move or bear weight on a joint or tendon area
  • Moderate or severe sunburn
  • Mood or mental changes (e.g., new or worsening anxiety, nervousness, agitation, confusion, depression, paranoia, restlessness, sleeplessness)
  • Muscle pain or weakness
  • New or worsening nightmares
  • Pain, soreness, redness, swelling, weakness, or bruising of a tendon or joint area
  • Red, swollen, blistered, or peeling skin
  • Seizures
  • Severe or persistent diarrhea
  • Severe or persistent dizziness, light-headedness, headache, tiredness, or weakness
  • Severe or persistent stomach pain or cramps
  • Shortness of breath or trouble breathing
  • Suicidal thoughts or actions
  • Symptoms of high or low blood sugar (e.g., dizziness; fainting; fast breathing; flushing; increased thirst, hunger, or urination; increased sweating; vision changes)
  • Symptoms of liver problems (e.g., dark urine, loss of appetite, pale stools, stomach pain, unusual nausea or vomiting, yellowing of the skin or eyes)
  • Tremors
  • Unusual bruising or bleeding
  • Vaginal discharge, irritation, or odor
  • Vision changes (e.g., blurred vision)
  • Wheezing

Interactions

What drugs may interact with grepiflox (levofloxacin)?

Grepiflox may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, including:

  • Antiarrhythmics (e.g., amiodarone, dofetilide, procainamide, quinidine, sotalol), arsenic, asenapine, bepridil, chloroquine, cisapride, citalopram, clozapine, crizotinib, dolasetron, droperidol, halofantrine, haloperidol, iloperidone, imidazoles (e.g., fluconazole, ketoconazole), macrolides (e.g., erythromycin), maprotiline, methadone, nilotinib, ondansetron, paliperidone, pentamidine, phenothiazines (e.g., chlorpromazine), pimozide, quetiapine, romidepsin, tacrolimus, telithromycin, tetrabenazine, toremifene, tricyclic antidepressants (e.g., nortriptyline), tyrosine kinase inhibitors (e.g., sunitinib), vandetanib, or ziprasidone because the risk of serious heart problems, including irregular heartbeat, may be increased.
  • Insulin or oral diabetes medicines (e.g., glyburide) because the risk of high or low blood sugar may be increased.
  • Corticosteroids (e.g., prednisone) because the risk of tendon problems may be increased.
  • Anticoagulants (e.g., warfarin) because the risk of bleeding may be increased.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) or theophylline because the risk of serious side effects, including seizures, may be increased.

Does food or alcohol interact with grepiflox (levofloxacin)?

Grepiflox may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with grepiflox (levofloxacin)?

Grepiflox may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • A history of severe or persistent diarrhea
  • Skin sensitivity to the sun
  • Diabetes
  • High blood sugar
  • Low blood sugar
  • Low blood potassium levels
  • Chest pain
  • Angina
  • Heart problems (e.g., enlarged heart, heart failure)
  • A stomach infection
  • Brain or nervous system problems
  • Myasthenia gravis
  • Increased pressure in the brain
  • Brain blood vessel problems
  • A history of seizures
  • A history of bone, joint, or tendon problems
  • Rheumatoid arthritis
  • Liver problems
  • Kidney problems or decreased kidney function
  • Nerve problems
  • A heart, kidney, or lung transplant
  • A certain type of irregular heartbeat (QT prolongation, long QT syndrome)

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using grepiflox (levofloxacin).

What is the dose of grepiflox (levofloxacin) for an adult?

Community-Acquired Pneumonia

The recommended dose is 500 mg PO/IV once daily for 7-14 days or 750 mg PO/IV once daily for 5 days.

Nosocomial Pneumonia

The recommended dose is 750 mg PO/IV once daily for 7-14 days.

Acute Bacterial Sinusitis

The recommended dose is 500 mg PO/IV once daily for 10-14 days or 750 mg PO/IV once daily for 5 days.

Acute Bacterial Exacerbation of Chronic Bronchitis

The recommended dose is 500 mg PO/IV once daily for ≥7 days.

Inhalational Anthrax – Post-exposure therapy

The recommended dose is 500 mg PO once daily for 60 days, beginning as soon as possible after exposure.

Skin/Skin Structure Infections

Uncomplicated: The recommended dose is 500 mg PO/IV once daily for 7-10 days.

Complicated: The recommended dose is 750 mg PO/IV once daily for 7-14 days.

Chronic Bacterial Prostatitis

The recommended dose is 500 mg PO/IV once daily for 28 days.

Complicated Urinary Tract Infections & Acute Pyelonephritis

The recommended dose is 250 mg PO/IV once daily for 10 days or 750 mg PO/IV once daily for 5 days.

Uncomplicated Urinary Tract Infections

The recommended dose is 250 mg PO/IV once daily for 3 days.

Plague

Indicated for treatment and prophylaxis of plague, including pneumonic and septicemic plague, caused by Yersinia pestis in adults and pediatric patients, aged 6 months or older.

The recommended dose is 500 mg PO/IV once daily for 10-14 days.

Acne Vulgaris (Off-label)

The recommended dose is 100 mg PO q8hr for 4 weeks.

Epididymitis (Off-label)

The recommended dose is 500 mg PO qDay for 10 days.

What is the dose of grepiflox (levofloxacin) for a child?

Inhalational Anthrax – Post-exposure therapy

≥6 months and <50 kg: The recommended dose is 8 mg/kg PO q12hr for 60 days, beginning as soon as possible after exposure; individual dose not to exceed 250 mg.

≥6 months and >50 kg: The recommended dose is 500 mg PO once daily for 60 days, beginning as soon as possible after exposure.

Plague

Indicated for treatment and prophylaxis of plague, including pneumonic and septicemic plague, caused by Yersinia pestis in adults and pediatric patients, aged 6 months or older.

≥6 months and <50 kg: The recommended dose is 8 mg/kg PO/IV q12hr for 10-14 days; individual dose not to exceed 250 mg.

≥50 kg: The recommended dose is 500 mg PO/IV once daily for 10-14 days.

Acute Bacterial Rhinosinusitis (Off-label)

The recommended dose is 10-20 mg/kg/day PO qDay or divided q12hr.

Community Acquired Pneumonia (Off-label)

S. pneumonia

  • 6 months – 5 years: The recommended dose is 16-20 mg/kg/day PO qDay for 10 days.
  • 5-16 years: The recommended dose is 8-10 mg/kg/day PO qDay for 10 days; not to exceed 750 mg/day.

M. pneumonia, C. trachomatis, C. pneumonia

  • Adolescents with skeletal maturity: The recommended dose is 500 mg PO qDay for 10 days; not to exceed 750 mg/day.

How is grepiflox (levofloxacin) available?

Grepiflox is available in the following dosage forms and strengths:

  • Levofloxacin infusion solution 500mg/100ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of grepiflox, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once or more than 1 dose in 1 day.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 10, 2017 | Last Modified: September 13, 2019

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