Generic Name: Glyburide Brand Name(s): Generics only. No brands available.


What is glyburide used for?

Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used to treat type 2 diabetes. This medicine is not for treating type 1 diabetes.

Glyburide may also be used for purposes not listed in this medication guide.

How should I take glyburide?

Take glyburide exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take glyburide with your first meal of the day, unless your doctor tells you otherwise.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor’s office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Older adults may be more likely to have low blood sugar while taking glyburide.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor’s advice.

Also check your blood sugar levels very closely during pregnancy.

If your doctor changes your brand, strength, or type of glyburide, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of glyburide you receive at the pharmacy.

How do I store glyburide?

Glyburide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store glyburide in the bathroom or the freezer. There may be different brands of glyburide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush glyburide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using glyburide?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of glyburide or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use this medicine if:

  • You are being treated with bosentan (Tracleer).
  • You have type 1 diabetes.
  • You are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure glyburide is safe for you, tell your doctor if you have:

  • Hemolytic anemia (a lack of red blood cells)
  • An enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD)
  • A nerve disorder affecting bodily functions
  • Liver or kidney disease
  • If you have taken chlorpropamide in the past 2 weeks
  • If you are allergic to sulfa drugs
  • If you have been using insulin or taking chlorpropamide (Diabinese)

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking glyburide.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using glyburide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking glyburide. Glyburide is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from glyburide?

Get emergency medical help if you have any signs of an allergic reaction to glyburide: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • Easy bruising or bleeding (nosebleeds, bleeding gums)
  • Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing
  • Liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Low levels of sodium in the body–headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady

Common side effects may include:

  • Nausea, upset stomach, heartburn, feeling full
  • Muscle or joint pain
  • Blurred vision
  • Mild rash or skin redness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with glyburide?

Glyburide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Exenatide (Byetta)
  • Probenecid (Benemid)
  • Aspirin or other salicylates (including Pepto Bismol)
  • A blood thinner (warfarin, Coumadin, Jantoven)
  • Sulfa drugs (Bactrim, SMZ-TMP, SMX-TMP, and others)
  • A monoamine oxidase inhibitor (MAOI)
  • Insulin or other oral diabetes medications

Does food or alcohol interact with glyburide?

Glyburide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with glyburide?

Glyburide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using glyburide.

What is the dose of glyburide for an adult?

Usual Adult Dose for Diabetes Type 2:

Initial dose: 2.5 mg (standard) or 1.5 mg (micronized) orally once a day in the morning with breakfast.

Maintenance dose: 1.25 to 20 mg (standard) or 0.75 to 12 mg (micronized) orally in 1 or 2 divided doses.

Maximum dose: 20 mg/day (standard) or 12 mg/day (micronized).

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

What is the dose of glyburide for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is glyburide available?

Glyburide is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of glyburide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 22, 2017 | Last Modified: September 2, 2017

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