Glucophage

By Medically reviewed by hellodoktor

Generic Name: Glucophage Brand Name(s): Glucophage and Glucophage.

Uses

What is Glucophage® (metformin) used for?

Glucophage® is commonly prescribed for patients with type 2 diabetes to control high blood sugar.

How should I take Glucophage® (metformin)?

For orally taken form, you should:

  • Take Glucophage® by mouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using Glucophage®.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store Glucophage® (metformin)?

Glucophage® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Glucophage® in the bathroom or the freezer. There may be different brands of Glucophage® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Glucophage® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Glucophage® (metformin)?

Before using Glucophage®, tell your doctor if you have:

  • Allergic reaction to excipients using for dosage form containing Glucophage®.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Used any other health conditions, drugs that have a risk of interaction with Glucophage®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Glucophage® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Glucophage®. Glucophage® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Glucophage® (metformin)?

As taking others medicines, taking Glucophage® can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of side effects are listed below:

  • Muscle pain
  • Weakness
  • Numb or cold feeling in your arms and legs
  • Trouble breathing
  • Feeling dizzy or light-headed
  • Stomach pain, nausea with vomiting
  • Slow or uneven heart rate
  • Feeling short of breath, even with mild exertion
  • Swelling or rapid weight gain
  • Flu symptoms (such as fever, chills, body aches)
  • Headache
  • Diarrhea

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Glucophage® (metformin)?

Glucophage® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Acetazolamide(Diamox)
  • Amiloride (Midamor, In Moduretic)
  • Angiotensin-Converting Enzyme (Ace) inhibitors such as Benazepril (Lotensin), Captopril (Capoten), Enalapril (Vasotec), Fosinopril (Monopril), Lisinopril (Prinivil, Zestril), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), And Trandolapril (Mavik)
  • Beta-Blockers such as Atenolol (Tenormin), Labetalol (Normodyne), Metoprolol (Lopressor, Toprol Xl), Nadolol (Corgard), and Propranolol (Inderal)
  • Calcium Channel Blockers such as Amlodipine (Norvasc), Diltiazem (Cardizem, Dilacor, Tiazac, Others), Felodipine (Plendil), Isradipine (Dynacirc), Nicardipine (Cardene), Nifedipine (Adalat, Procardia), Nimodipine (Nimotop), Nisoldipine (Sular), and Verapamil (Calan, Isoptin, Verelan)
  • Cimetidine (Tagamet)
  • Digoxin (Lanoxin)
  • Diuretics (Water Pills)
  • Furosemide (Lasix)
  • Hormone Replacement Therapy
  • Insulin or other medications for diabetes
  • Isoniazid
  • Medications for asthma and colds
  • Medications for mental illness and nausea
  • Medications for thyroid disease
  • Morphine (Ms Contin, Others)
  • Niacin
  • Oral contraceptives (Birth Control Pills)
  • Oral steroids such as Dexamethasone (Decadron, Dexone), Methylprednisolone (Medrol), and Prednisone (Deltasone)
  • Phenytoin (Dilantin, Phenytek)
  • Procainamide (Procanbid)
  • Quinidine
  • Quinine
  • Ranitidine (Zantac)
  • Topiramate (Topamax)
  • Triamterene (Dyazide, Maxzide, Others)
  • Trimethoprim (Primsol)
  • Vancomycin (Vancocin)
  • Zonisamide (Zonegran)

Does food or alcohol interact with Glucophage® (metformin)?

Glucophage® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Glucophage® (metformin)?

Glucophage® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as:

  • Alcohol, excessive use
  • Underactive adrenal glands
  • Underactive pituitary gland
  • Undernourished condition
  • Weakened physical condition
  • Any other condition that causes low blood sugar
  • Anemia (low levels of red blood cells)
  • Vitamin B12 deficiency
  • Congestive heart failure, acute or unstable
  • Dehydration
  • Heart attack, acute
  • Hypoxemia (decreased oxygen in the blood)
  • Liver disease
  • Sepsis (blood poisoning)
  • Shock (low blood pressure, blood circulation is poor)
  • Diabetic ketoacidosis (ketones in the blood)
  • Kidney disease, severe
  • Metabolic acidosis (extra acids in the blood)
  • Type 1 diabetes
  • Fever
  • Infection
  • Surgery
  • Trauma

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Glucophage® (metformin).

What is the dose of Glucophage® (metformin) for an adult?

Consult your doctor for information about the dose of Glucophage®.

Recommended doses in some cases are listed below:

  • Immediate-release:
    • Initial dose: 500 mg orally twice a day or 850 mg orally once a day.
    • Dose titration: Increase in 500 mg weekly increments or 850 mg every 2 weeks as tolerated.
    • Maintenance dose: 2000 mg daily.
    • Maximum dose: 2550 mg daily.
  • Extended-release:
    • Initial dose: 500 to 1000 mg orally once a day.
    • Dose titration: Increase in 500 mg weekly increments as tolerated.
    • Maintenance dose: 2000 mg daily.
    • Maximum dose: 2500 mg daily.

What is the dose of Glucophage® (metformin) for a child?

Consult your doctor for information about the dose of Glucophage®.

Recommended doses in some cases are listed below:

Diabetes type 2: applied for children from 10 years or older:

  • Immediate-release:
    • Initial dose: 500 mg orally twice a day.
    • Dose titration: Increase in 500 mg weekly increments as tolerated.
    • Maintenance dose: 2000 mg daily.
    • Maximum dose: 2000 mg daily.

The dosage has not been established in pediatric patients less than 10 years. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Glucophage® (metformin) available?

Glucophage® is available in the following dosage forms and strengths:

  • Tablet Extended Release, Oral: 500 mg, 1000 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Glucophage®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: January 8, 2017 | Last Modified: September 12, 2019

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