Generic Name: Geodon Brand Name(s): Generics only. No brands available.


What is Geodon® (ziprasidone) used for?

Geodon® is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Geodon® is used to treat schizophrenia and the manic symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Geodon® may also be used for purposes not listed in this medication guide.

How should I take Geodon® (ziprasidone)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with food. Swallow the capsule whole.

While using Geodon®, you may need frequent blood tests. Your kidney or liver function may also need to be checked.

If you are diabetic, check your blood sugar levels on a regular basis while you are taking Geodon®.

Use Geodon® regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

It may take several weeks before your symptoms improve. Do not stop using Geodon® suddenly, even if you feel fine. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

How do I store Geodon® (ziprasidone)?

Geodon® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Geodon® in the bathroom or the freezer. There may be different brands of Geodon® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Geodon® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Geodon® (ziprasidone)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Geodon® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Geodon® if you are allergic to ziprasidone, or if you have:

  • A heart rhythm disorder
  • A personal or family history of Long QT syndrome
  • Uncontrolled or untreated heart failure
  • If you have recently had a heart attack

Geodon® is not approved for use in psychotic conditions related to dementia. Geodon may increase the risk of death in older adults with dementia-related conditions.

Geodon® should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur:

  • Anagrelide
  • Methadone
  • Tacrolimus
  • Medicine to prevent nausea or vomiting – dolasetron, droperidol, ondansetron
  • An antibiotic – azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine
  • Cancer medicine – arsenic trioxide, vandetanib
  • An antidepressant – citalopram, escitalopram
  • Anti-malaria medication – chloroquine, halofantrine, mefloquine
  • Heart rhythm medicine – amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol
  • Medicine to treat a psychiatric disorder – chlorpromazine, haloperidol, mesoridazine, pimozide, thioridazine

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Geodon®, do not stop taking it without your doctor’s advice.

It is not known whether ziprasidone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Older adults may be more sensitive to the effects of this medicine.

Geodon® is not approved for use by anyone younger than 18 years old.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Geodon® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Geodon®. Geodon® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Geodon® (ziprasidone)?

Get emergency medical help if you have signs of an allergic reaction to Geodon®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Geodon® may cause a severe skin reaction that can be fatal if it spreads to other parts of the body. Stop using this medicine and call your doctor right away if you have a new or worsening skin rash with fever, swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough, or trouble breathing.

Also call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Chest pain, fast or pounding heartbeats
  • Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Low white blood cell counts – sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, pain when swallowing
  • High blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss
  • Severe nervous system reaction – very stiff (rigid) muscles, high fever, sweating, confusion, agitation
  • Severe skin reaction – fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling

Common side effects may include:

  • Dizziness, drowsiness, unusual tiredness
  • Nausea, upset stomach
  • Diarrhea, constipation
  • Feeling restless
  • Tremors
  • Rash
  • Runny nose, new or worsening cough

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Geodon® (ziprasidone)?

Geodon® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Any heart problems
  • A history of heart attack or stroke
  • A history of bone marrow or blood cell disorder
  • A history of breast cancer
  • Low blood levels of potassium or magnesium
  • Diabetes (ziprasidone may raise your blood sugar)
  • Seizures or epilepsy
  • A history of suicidal thoughts
  • Alzheimer’s disease
  • Trouble swallowing
  • Liver disease
  • Kidney disease

Does food or alcohol interact with Geodon® (ziprasidone)?

Geodon® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Geodon® (ziprasidone)?

Geodon® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Geodon® (ziprasidone).

What is the dose of Geodon® (ziprasidone) for an adult?

Usual Adult Dose for Schizophrenia:


  • Initial dose: 20 mg orally twice a day
  • Maintenance dose: Adjust as clinically indicated at intervals of not less than 2 days
  • Maximum dose: 100 mg twice a day


  • Recommended dose: 10 to 20 mg IM; may repeat 10 mg IM every 2 hours or 20 mg IM every 4 hours up to maximum daily dose
  • Maximum dose: 40 mg IM per day
  • Duration of therapy: Use beyond 3 consecutive days has not been studied

Usual Adult Dose for Bipolar Disorder:

Acute Treatment of Manic or Mixed Episodes:

  • Initial dose: 40 mg orally twice daily
  • Increase dose to 60 mg or 80 mg twice daily on the second day; subsequently adjust dose based on tolerance and efficacy within the dose range of 40 to 80 mg orally twice a day
  • Maintenance Treatment (as adjunct to lithium or valproate): Once stabilized, continue on same dose within the range of 40 to 80 mg orally twice daily.

What is the dose of Geodon® (ziprasidone) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Geodon® (ziprasidone) available?

Geodon® is available in the following dosage forms and strengths:

  • Capsule; injection: ziprasidone hydrochloride 20mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Geodon®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 28, 2017 | Last Modified: September 2, 2017

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