Generic Name: Fondaparinux Brand Name(s): Generics only. No brands available.

Know the basics

What is fondaparinux used for?

Fondaparinux is used to treat serious blood clots in the legs and/or lungs. It is usually used with another “blood thinner” medication (warfarin). If untreated, blood clots can travel to the lungs, heart, or brain, causing serious (possibly fatal) breathing problems, heart attack, or stroke. This drug may also be used to prevent blood clots after certain surgeries with an increased risk of blood clots (such as hip fracture, abdominal, knee/hip replacement).

Fondaparinux is known as a “blood thinner” (anticoagulant). It is a drug similar toheparin that works by blocking certain natural substances in the blood that cause clotting.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by yourhealth care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat certain types of heart attack and a specific type of chest pain called unstable angina.

How should I take fondaparinux?

This medication is given by injection under the skin of the stomach/abdomen as directed by your doctor, usually once daily. Do not inject into a muscle. The dosage and length of treatment are based on your medical condition and response to treatment. The dosage may also be based on your weight. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the product package. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not mix any other medication in the same injection. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. To minimize bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely.

When treating a blood clot, another “blood thinner” (warfarin) is usually started within 3 days after you start using fondaparinux. Your doctor will direct you to use both of these medications until the warfarin is working well. Do not stop either of these medications until your doctor directs you to stop.

To prevent blood clots due to surgery, your doctor may direct you to start using this medication after surgery (such as 6 to 8 hours after knee/hip replacement surgery) and continue for several days. Follow your doctor’s directions closely. Starting this medication too soon after surgery may increase the risk of serious bleeding.

This medication may also be given by injection into a vein by a health care professional, as directed by your doctor.

How do I store fondaparinux?

Fondaparinux is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store fondaparinux in the bathroom or the freezer. There may be different brands of fondaparinux that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush fondaparinux down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using fondaparinux?

Before using fondaparinux injection,

  • tell your doctor and pharmacist if you have had a serious allergic reaction (difficulty breathing or swallowing or swelling of the face, throat, tongue, lips, or eyes) to fondaparinux. Your doctor will probably tell you not to use fondaparinux. Also tell your doctor if you are allergic to any other medications, or any of the ingredients in fondaparinux injection. Ask your pharmacist for a list of the ingredients. Also tell your doctor and pharmacist if you are allergic to latex.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you weigh 110 pounds (50 kg) or less, are bleeding anywhere on your body or have a low number of platelets (blood clotting cells) in your blood, endocarditis (an infection in the heart), or kidney disease. Your doctor will probably tell you not to use fondaparinux injection.
  • tell your doctor if you have or have ever had ulcers in your stomach or intestines, high blood pressure, a stroke or ministroke (TIA), eye disease due to diabetes, or liver disease. Also tell your doctor if you have recently had brain, eye, or spinal surgery.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking fondaparinux injection, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking fondaparinux injection

Is it safe to take fondaparinux during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Know the side effects

What are the side effects of fondaparinux?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using fondaparinux and call your doctor at once if you have a serious side effect such as:

  • unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;
  • easy bruising, purple or red pinpoint spots under your skin;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • black or bloody stools, coughing up blood or vomit that looks like coffee grounds;
  • numbness, tingling, or muscle weakness (especially in your legs and feet);
  • loss of movement in any part of your body;
  • sudden weakness, severe headache, confusion, or problems with speech, vision, or balance;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, limp feeling).

Less serious side effects may include:

  • sleep problems (insomnia);
  • mild skin rash;
  • dizziness;
  • minor bleeding, rash, or itching where the medicine was injected.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with fondaparinux?

Fondaparinux may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with fondaparinux, especially other medicines used to treat or prevent blood clots, such as:

  • abciximab, clopidogrel, dipyridamole, eptifibatide, ticlopidine, tirofiban;
  • alteplase, reteplase, tenecteplase, urokinase;
  • apixaban, argatroban, bivalirudin, dabigatran, desirudin, lepirudin, rivaroxaban; or
  • dalteparin, enoxaparin, heparin, tinzaparin.
  • This list is not complete. Other drugs may interact with fondaparinux, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Does food or alcohol interact with fondaparinux?

Fondaparinux may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with fondaparinux?

Fondaparinux may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Bleeding problems;
  • Blood vessel problems;
  • Catheter insertion in the spine;
  • Diabetic retinopathy (eye problem);
  • Hypertension (high blood pressure), uncontrolled;
  • Liver disease;
  • Stomach or bowel problems (eg, ulcers), active;
  • Stroke, recent or history of;
  • Surgery (eg, eye, brain, or spine), recent or history of—Use with caution. The risk of bleeding may be increased.
  • Heart infection;
  • Kidney disease, severe;
  • Major bleeding, active;
  • Thrombocytopenia (low platelet count in the blood);
  • Weight of less than 110 pounds—Should not be used in patients with these conditions.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal from the body.

Understand the Dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before using this medication.

What is the dose of Fondaparinux for an adult?

Usual Adult Dose for Deep Vein Thrombosis

Dosage is based on patient’s weight:
-Under 50 kg: 5 mg subcutaneously once a day
-50 to 100 kg: 7.5 mg subcutaneously once a day
-Over 100 kg: 10 mg subcutaneously once a day
Duration of therapy: At least 5 days, until INR of 2 to 3 achieved with warfarin

Usual Adult Dose for Pulmonary Embolism

Dosage is based on patient’s weight:
-Under 50 kg: 5 mg subcutaneously once a day
-50 to 100 kg: 7.5 mg subcutaneously once a day
-Over 100 kg: 10 mg subcutaneously once a day
Duration of therapy: At least 5 days, until INR of 2 to 3 achieved with warfarin

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Abdominal Surgery

2.5 mg subcutaneously once a day after hemostasis is established, starting no sooner than 6 to 8 hours after surgery
Duration of therapy: 5 to 9 days

Usual Adult Dose for Deep Vein Thrombosis – Prophylaxis

2.5 mg subcutaneously once a day after hemostasis is established, starting no sooner than 6 to 8 hours after surgery
Duration of therapy: 5 to 9 days

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

2.5 mg subcutaneously once a day after hemostasis is established, starting no sooner than 6 to 8 hours after surgery
Duration of therapy: 5 to 9 days

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery

2.5 mg subcutaneously once a day after hemostasis is established, starting no sooner than 6 to 8 hours after surgery
Duration of therapy: 5 to 9 days

What is the dose of Fondaparinux for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is fondaparinux available?

Fondaparinux is available in the following dosage forms and strengths:

Solution, Subcutaneous, as sodium: 2.5 mg/0.5 mL, 5 mg/0.4 mL, 7.5 mg/0.6 mL, 10 mg/0.8 mL
Solution, subcutaneous, as sodium [preservative free]: 2.5 mg/0.5 mL, 5 mg/0.4 mL, 7.5 mg/0.6 mL, 10 mg/0.8 mL.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of fondaparinux, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 4, 2017 | Last Modified: January 4, 2017

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