By Medically reviewed by hellodoktor

Generic Name: Fentanyl Brand Name(s): Generics only. No brands available.

Know the basics

What is fentanyl used for?

Fentanyl is one of the narcotic analgesics commonly used for relieving severe pain during and after surgery by acting in the central nervous system or brain.

How should I take fentanyl?

For injection form, you should:

  • Receive fentanyl injected by health care professional in hospital by a dose calculated by your doctor.
  • Read the label carefully before using fentanyl hydrochloride.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store fentanyl?

Fentanyl is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store fentanyl in the bathroom or the freezer. There may be different brands of fentanyl that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush fentanyl down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using fentanyl?

Before using fentanyl, tell your doctor if you have:

  • Allergic reaction: to fentanyl, excipients using for dosage form containing Fentanyl. The information is detailed in the leaflet.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Pediatric.
  • Geriatric.
  • Used any other health conditions, drugs that have a risk of interaction with fentanyl.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using fentanyl during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking fentanyl.

Know the side effects

What side effects can occur from fentanyl?

As taking others medicines, taking fentanyl can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Chest pain or discomfort;
  • Difficult or troubled breathing;
  • Irregular, fast or slow, or shallow breathing;
  • Lightheadedness, dizziness, or fainting;
  • Pale or blue lips, fingernails, or skin;
  • Severe muscle stiffness;
  • Shortness of breath;
  • Slow or irregular heartbeat;
  • Unusual tiredness;
  • Blurred vision;
  • Change in consciousness;
  • Chills;
  • Confusion;
  • Cough;
  • Difficulty with swallowing;
  • Fast heartbeat;
  • Feeling cold;
  • Headache;
  • Hives;
  • Inability to move the eyes;
  • Inability to sit still;
  • Increased blinking or spasms of the eyelid;
  • Itching;
  • Low blood pressure or pulse;
  • Nervousness;
  • Pounding in the ears;
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue;
  • Restlessness;
  • Seeing, hearing, or feeling things that are not there;
  • Skin rash;
  • Sticking out the tongue when not meaning to;
  • Sweating;
  • Tightness in the chest;
  • Uncontrolled twisting movements of the neck, trunk, arms, or legs;
  • Unusual facial expressions.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with fentanyl?

Fentanyl may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, such as:

Blinatumomab; Bromazepam; Brompheniramine; Buprenorphine; Buspirone; Butabarbital; Butalbital; Butorphanol; Carbamazepine; Carbinoxamine; Carisoprodol; Carphenazine; Ceritinib; Chloral Hydrate; Chlordiazepoxide; Chlorpheniramine; Chlorpromazine; Chlorzoxazone; Cimetidine; Ciprofloxacin; Citalopram; Clarithromycin; Clobazam; Clonazepam; Clorazepate; Clorgyline; Clozapine; Cocaine; Codeine; Conivaptan; Crizotinib; Cyclobenzaprine; Cyclosporine; Dabrafenib; Darunavir; Delavirdine; Desipramine; Desogestrel; Desvenlafaxine; Dexmedetomidine; Dextromethorphan; Diacetylmorphine; Diazepam; Dichloralphenazone; Dienogest; Difenoxin; Dihydrocodeine; Diltiazem; Diphenhydramine; Diphenoxylate; Dolasetron; Donepezil; Doxepin; Doxylamine; Droperidol; Drospirenone; Duloxetine; Eletriptan; Enflurane; Enzalutamide; Erythromycin; Escitalopram; Estazolam; Estradiol; Eszopiclone; Ethchlorvynol; Ethinyl Estradiol; Ethopropazine; Ethylmorphine; Ethynodiol; Etonogestrel;

Amprenavir; Benperidol; Bicalutamide;



Flibanserin; Fluconazole; Flunitrazepam; Fluoxetine; Fluphenazine; Flurazepam; Fluspirilene; Fluvoxamine; Fosamprenavir; Fosaprepitant; Fosphenytoin; Fospropofol; Frovatriptan; Furazolidone; Ginkgo Biloba; Goldenseal; Golimumab; Granisetron; Halazepam; Haloperidol; Halothane; Hexobarbital; Hydrocodone; Hydromorphone; Hydroxytryptophan; Hydroxyzine; Idelalisib; Imatinib; Imipramine; Indinavir; Iproniazid; Isocarboxazid; Isoflurane; Isoniazid; Itraconazole; Ketamine; Ketazolam; Ketobemidone; Ketoconazole; Levomilnacipran; Levonorgestrel; Levorphanol; Linezolid; Lithium; Lomitapide; Lorazepam; Lorcaserin; Lumacaftor; Meclizine; Melperone; Meperidine; Mephobarbital; Meprobamate; Meptazinol; Mesoridazine; Mestranol; Metaxalone; Methadone;

Atazanavir; Boceprevir; Cobicistat; Lopinavir; Mifepristone; Naltrexone; Nelfinavir; Ritonavir; Saquinavir; Telaprevir; Tipranavir; Abiraterone; Acepromazine; Alefacept; Amitriptyline; Amlodipine; Amobarbital; Amoxapine;


Methdilazine; Methocarbamol; Methohexital; Methotrimeprazine; Methylene Blue; Miconazole; Midazolam; Milnacipran; Mirtazapine; Moclobemide; Molindone; Moricizine; Morphine; Morphine Sulfate Liposome; Nalbuphine; Naratriptan; Nefazodone; Nialamide; Nicardipine; Nicomorphine; Nifedipine; Nilotinib; Nitrazepam; Nitrous Oxide; Norelgestromin; Norethindrone; Norgestimate; Norgestrel; Nortriptyline; Olanzapine; Opium; Opium Alkaloids; Orphenadrine; Osimertinib; Ospemifene; Oxazepam; Oxycodone; Oxymorphone; Palonosetron; Papaveretum; Paregoric; Pargyline; Paroxetine; Pazopanib; Pentazocine; Pentobarbital; Perazine; Periciazine; Perphenazine; Phenelzine; Phenobarbital; Phenytoin; Pimozide; Piperacetazine; Piperaquine; Pipotiazine; Piritramide; Posaconazole; Prazepam; Primidone; Procarbazine; Prochlorperazine; Promazine; Promethazine; Propofol; Propoxyphene; Quazepam; Quetiapine; Ramelteon;

Alfentanil; Almotriptan; Alprazolam; Amiodarone; Amisulpride;

Ranitidine; Ranolazine; Rasagiline; Regorafenib; Remifentanil; Remoxipride; Rifabutin; Rifampin; Rifapentine; Rizatriptan; Safinamide; Secobarbital; Secukinumab; Selegiline; Sertindole; Sertraline; Sibutramine; Siltuximab; Sodium Oxybate; St John’s Wort; Sufentanil; Sulpiride; Sumatriptan; Suvorexant; Tapentadol; Telithromycin; Temazepam; Thiethylperazine; Thiopental; Thiopropazate; Thioridazine; Ticagrelor; Tilidine; Tizanidine; Tolonium Chloride; Toloxatone; Topiramate; Tramadol; Tranylcypromine; Trazodone; Triazolam; Trifluoperazine; Trifluperidol; Triflupromazine; Trimeprazine; Troleandomycin; Tryptophan; Venlafaxine; Verapamil; Vilazodone; Voriconazole; Vortioxetine; Zaleplon; Zileuton; Ziprasidone; Zolmitriptan; Zolpidem; Zopiclone; Zotepine; Azithromycin; Clotrimazole; Dirithromycin; Econazole; Josamycin; Mepartricin; Miokamycin; Nevirapine; Rokitamycin; Roxithromycin; Spiramycin;

Anileridine; Aprepitant; Aripiprazole; Asenapine;

Does food or alcohol interact with fentanyl?

Fentanyl may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with fentanyl?

Fentanyl may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as:

  • Bradycardia (slow heart rhythm);
  • Breathing problems or difficult breathing;
  • Chronic obstructive pulmonary disease (COPD) ;
  • Heart rhythm problems (eg, QT prolongation) ;
  • Hypertension (high blood pressure);
  • Brain tumor;
  • Head injury;
  • Heart disease;
  • Hypokalemia (eg, low potassium in the blood);
  • Hypomagnesemia;
  • Kidney disease;
  • Liver disease.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using fentanyl.

What is the dose of fentanyl for an adult?

Consult your doctor for information about the  dose of fentanyl hydrochloride.  Recommended doses in some cases are listed below:

Surgery Premedication: 50-100 mcg/dose  IM or slow IV can be taken 30-60 min prior to surgery.

Adjunct to regional anesthesia: 25-100 mcg/dose slow IV over 1-2 min.

General Anesthesia

  • Minor surgical procedures: 0.5-2 mcg/kg/dose IV.
  • Major surgery: 2-20 mcg/kg/dose initially; 1-2 mcg/kg/hr maintenance infusion IV; discontinue infusion 30-60 min prior to end of surgery; limit total fentanyl doses to 10-15 mcg/kg for fast tracking and early extubation.
  • Adjunct to general anesthesia (rarely used): 20-50 mcg/kg/dose IV.

Analgesia (Off-label)

  • Analgesia: 1-2 mcg/kg IV bolus or 25-100 mcg/dose PRN or 1-2 mcg/kg/hr by continuous IV infusion or 25-200 mcg/hr.
  • Severe pain: 50-100 mcg/dose IV/IM q1-2hr PRN (patients with prior opioid exposure may tolerate higher initial doses).
  • Patient controlled anesthesia (PCA): 10 mcg/mL IV (usual concentration); 20 mcg demand dose with 5-10 min lockout time interval and base rate of ≤50mcg/hr.

What is the dose of fentanyl for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is fentanyl available?

Fentanyl is available in the following dosage forms and strengths:

  • Contains fentanyl citrate the equivalent of 50 micrograms of fentanyl in 1ml.
  • Each 2ml ampoule contains 100 micrograms of Fentanyl as fentanyl citrate.
  • Each 10ml ampoule contains 500 micrograms of Fentanyl as fentanyl citrate.

What should I do if I miss a dose?

If you miss a dose of fentanyl, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 6, 2016 | Last Modified: September 13, 2019

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