Generic Name: Famotidine Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: B

Uses

What is Famotidine used for?

Famotidine is known as an H2 blocker. It works by reducing the amount of acid in your stomach. It is used to prevent and treat heartburn and other symptoms caused by too much acid in the stomach (acid indigestion).

How should I take Famotidine?

To treat heartburn and acid indigestion, take 1 tablet or capsule with a glass of water as needed, unless otherwise directed by your doctor. Swallow the tablets and capsules whole without chewing. If you are using the chewable tablets, chew completely and swallow one tablet as needed. Do not swallow whole. Famotidine can be taken with or without food.

To prevent heartburn and acid indigestion, take famotidine 15-60 minutes before eating food or drinking beverages that can cause indigestion.

Do not take more than 2 tablets in 24 hours unless directed by your doctor. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

Stop taking this medication and call your doctor promptly if your symptoms continue after you begin taking it, or if they do not improve after you have been taking this medication for 14 days in a row. Do not take this medication for more than 14 days in a row without talking with your doctor.

How do I store Famotidine?

Famotidine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Famotidine in the bathroom or the freezer. Do not allow the liquid medicine to freeze. Throw away any unused liquid medicine that is older than 30 days. There may be different brands of Famotidine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Famotidine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Famotidine?

Before taking famotidine, tell your doctor or pharmacist if you are allergic to it; or to other H2 blockers (e.g., cimetidine, ranitidine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this medication: kidney problems, liver problems, other stomach problems (e.g., tumors).

Some symptoms may actually be signs of a more serious condition. Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss.

In addition, before you self-treat with this medication, get medical help right away if you have any of these signs of a serious condition: trouble/pain swallowing food, bloody vomit, vomit that looks like coffee grounds, bloody/black stools, heartburn for over 3 months, frequent chest pain, frequent wheezing (especially with heartburn), nausea/vomiting, stomach pain.

This chewable form of this medication contains aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist regarding the safe use of this medication.

Do not use this medication in children younger than 12 unless directed by the doctor.

Older adults may be more sensitive to the side effects of this drug, especially confusion.

During pregnancy, this medication should only be used if clearly needed. Discuss the risks and benefits with your doctor. Tell your doctor if you are pregnant before using this medication.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Famotidine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Famotidine. Famotidine is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Famotidine?

Headache, constipation or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, fast/slow/irregular heartbeat, signs of infection (such as sore throat that doesn’t go away, fever, chills), mental/mood changes (e.g., restlessness, confusion, depression, hallucinations), seizure.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Famotidine?

Some products need stomach acid so that the body can absorb them properly. Famotidine decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, dasatinib, delavirdine, certain azole antifungals (such as itraconazole, ketoconazole), pazopanib, among others.

Do not take this medication with other products that contain famotidine or other H2 blockers (cimetidine, nizatidine, ranitidine).

Famotidine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Famotidine?

Famotidine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Famotidine?

Famotidine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Famotidine.

What is the dose of Famotidine for an adult?

Usual Adult Dose for Duodenal Ulcer

Oral:

-Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day

-Maintenance dose: 20 mg orally once a day at bedtime

-Duration of therapy: 4 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comments:

-Most patients who received oral formulations healed within 4 weeks, with few patients requiring treatment for 6 to 8 weeks; there are no safety data for the treatment of uncomplicated active duodenal ulcer beyond 8 weeks. Studies have not been conducted in patients receiving oral maintenance therapy for longer than 1 year.

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

Uses:

-Short-term treatment of active duodenal ulcer

-Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer

-Hospitalized patients with intractable ulcers, or as an alternative to the oral dosage forms for short-term use in patients who are unable to take oral medication for active duodenal ulcers

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for duodenal ulcer maintenance therapy

Usual Adult Dose for Peptic Ulcer

Oral:

-Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day

-Maintenance dose: 20 mg orally once a day at bedtime

-Duration of therapy: 4 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comments:

-Most patients who received oral formulations healed within 4 weeks, with few patients requiring treatment for 6 to 8 weeks; there are no safety data for the treatment of uncomplicated active duodenal ulcer beyond 8 weeks. Studies have not been conducted in patients receiving oral maintenance therapy for longer than 1 year.

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

Uses:

-Short-term treatment of active duodenal ulcer

-Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer

-Hospitalized patients with intractable ulcers, or as an alternative to the oral dosage forms for short-term use in patients who are unable to take oral medication for active duodenal ulcers

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for duodenal ulcer maintenance therapy

Usual Adult Dose for Gastric Ulcer

Oral:

-Usual dose: 40 mg orally once a day at bedtime

-Duration of therapy: 6 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comments:

-Most patients who received oral formulations healed within 6 weeks; there are no safety data for the treatment of uncomplicated active benign gastric ulcer beyond 8 weeks.

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

Uses:

-Short-term treatment of active benign gastric ulcer

-Hospitalized patients with intractable ulcers, or as an alternative to the oral dosage forms for short-term use in patients who are unable to take oral medication for active benign gastric ulcers

Usual Adult Dose for Gastroesophageal Reflux Disease

Oral:

-Usual dose: 20 mg orally 2 times day

-Duration of therapy: Up to 6 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comment:

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

Uses:

-Short-term treatment of gastroesophageal reflux disease (GERD)

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for GERD

Usual Adult Dose for Erosive Esophagitis

Oral:

-Usual dose: 20 to 40 mg orally 2 times a day

-Duration of therapy: Up to 12 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comment:

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

Uses:

-Short-term treatment of esophagitis due to gastroesophageal reflux disease (GERD), including erosive/ulcerative disease diagnosed by endoscopy

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for esophagitis due to GERD

Usual Adult Dose for Zollinger-Ellison Syndrome

Oral:

-Initial dose: 20 mg orally every 6 hours

-Maximum dose: 160 mg orally every 6 hours

Parenteral:

-Usual dose: 20 mg IV every 6 to 12 hours

Comments:

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

-Dosing should be determined on an individual basis.

-Treatment should be continued for as long as clinically necessary.

Uses:

-Treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and multiple endocrine adenomas

-Some hospitalized patients with pathological hypersecretory conditions

Usual Adult Dose for Pathological Hypersecretory Conditions

Oral:

-Initial dose: 20 mg orally every 6 hours

-Maximum dose: 160 mg orally every 6 hours

Parenteral:

-Usual dose: 20 mg IV every 6 to 12 hours

Comments:

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

-Dosing should be determined on an individual basis.

-Treatment should be continued for as long as clinically necessary.

Uses:

-Treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and multiple endocrine adenomas

-Some hospitalized patients with pathological hypersecretory conditions

Usual Adult Dose for Dyspepsia

Oral:

Over-the-Counter (OTC) Formulations:

-Treatment dose: 10 to 20 mg orally once

-Symptom prevention: 10 to 20 mg orally once 10 to 60 minutes prior to consuming food/beverages that cause heartburn

-Maximum dose: 2 tablets/day

-Maximum duration of therapy: 14 days

Comments:

-OTC tablet formulations should be taken with a glass of water.

-Chewable tablet formulations should be chewed completely before swallowing.

Uses:

-Relief of heartburn associated with acid indigestion and sour stomach

-Prevention of heartburn associated with acid indigestion and sour stomach brought on by eating/drinking certain foods and beverages

Renal Dose Adjustments

Mild renal dysfunction (CrCl 50 to 90 mL/min): No adjustment recommended.

Moderate (CrCl less than 50 mL/min) to severe renal dysfunction (CrCl less than 10 mL/min): Reduce the dose by 50% and/or prolong the dosing interval to 36 to 48 hours

Dose Adjustments

-Elderly patients: Dose selection should take into account age-related changes in renal function, and additional renal function monitoring may be necessary. Elderly patients with moderate to severe renal function should follow renal dose adjustments.

Other Comments

Administration advice:

-Patients may use antacids concomitantly with treatment.

-Oral suspension: Patients should shake the oral suspension vigorously for 5 to 10 seconds prior to use.

-Oral dissolving tablets (ODT): Tablets should be removed just prior to use. Patients should take the tablet out of the bottle with dry hands and place on the tongue to be dissolved and swallowed. ODTs typically disintegrate within 2 minutes.

-Tablets: Tablets may be divided, but patients should avoid chewing/crushing tablets during administration.

Storage requirements:

-The manufacturer product information should be consulted.

Reconstitution/preparation techniques:

-The manufacturer product information should be consulted.

IV compatibility:

-The manufacturer product information should be consulted.

General:

-This drug was not found to affect fasting or postprandial gastrin levels, gastric emptying, or exocrine pancreatic function.

-Patients with hypersecretory conditions have used this drug for over 1 year without experiencing tachyphylaxis or significant adverse effects.

Monitoring:

-Renal function, especially in patients with/at risk of renal dysfunction

Patient advice:

-Patients should be told to discard any oral suspension remaining after 30 days.

-Inform patients that this drug may cause dizziness, confusion, or hallucinations, and they should avoid driving or operating machinery until the full effects of the drug are seen.

-Patients should be instructed to contact their healthcare provider if symptoms do not improve or worsen during treatment.

-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

What is the dose of Famotidine for a child?

Usual Pediatric Dose for Peptic Ulcer

1 TO 16 YEARS:

Oral:

-Usual dose: 0.5 mg/kg orally once a day at bedtime OR 0.25 mg/kg orally 2 times a day

-Maximum dose: 40 mg/day

Parenteral:

-Initial dose: 0.25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours

-Maximum dose: 40 mg/day

16 YEARS AND OLDER:

Oral:

-Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day

-Maintenance dose: 20 mg orally once a day at bedtime

-Duration of therapy: 4 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comments:

-Uncontrolled clinical trials have used oral doses up to 1 mg/kg in patients 1 to 16 years of age.

-Gastric acid suppression occurred at IV doses of 0.5 mg/kg every 12 hours.

Uses:

-Short-term treatment of active duodenal ulcer

-Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer

-Hospitalized patients with intractable ulcers, or as an alternative to the oral dosage forms for short-term use in patients who are unable to take oral medication for active duodenal ulcers

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for duodenal ulcer maintenance therapy

Usual Pediatric Dose for Gastroesophageal Reflux Disease

LESS THAN 3 MONTHS:

Oral:

-Initial dose: 0.5 mg/kg orally once a day

-Duration of therapy: Up to 8 weeks

3 MONTHS TO LESS THAN 1 YEAR:

Oral:

-Initial dose: 0.5 mg/kg orally 2 times a day

-Duration of therapy: Up to 8 weeks

1 YEAR TO 16 YEARS:

Oral:

-Usual dose: 0.5 mg/kg/day orally 2 times a day

-Maximum dose: Up to 40 mg/dose

Parenteral:

-Initial dose: 0.25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours

-Maximum dose: 40 mg/day

16 YEARS AND OLDER:

Oral:

-Usual dose: 20 mg orally 2 times day

-Duration of therapy: Up to 6 weeks

Parenteral:

-Usual dose: 20 mg IV every 12 hours

Comments:

-The concomitant use of conservative measures (e.g., thickened feedings) should be considered during treatment.

-Parenteral treatment should be limited to patients who cannot tolerate oral formulations.

-Uncontrolled clinical trials have used oral doses up to 2 mg/kg in patients 1 to 16 years of age with gastroesophageal reflux disease (GERD) with/without esophagitis (including erosions ad ulcerations).

-Oral dissolving tablets may be used in patients 6 years and older, but should be taken as an intact tablet.

Uses:

-Short-term treatment of esophagitis due to gastroesophageal reflux disease, including erosive/ulcerative disease diagnosed by endoscopy

-Alternative to the oral dosage forms for short-term use in specific hospitalized patients who are unable to take oral medication for GERD

Usual Pediatric Dose for Dyspepsia

12 YEARS AND OLDER:

Oral:

Over-the-Counter (OTC) Formulations:

-Treatment dose: 10 to 20 mg orally once

-Symptom prevention: 10 to 20 mg orally once 10 to 60 minutes prior to consuming food/beverages that cause heartburn

-Maximum dose: 2 tablets/day

-Maximum duration of therapy: 14 days

Comments:

-OTC formulations should be taken with a glass of water.

-Chewable tablet formulations should be chewed completely before swallowing.

Uses:

-Relief of heartburn associated with acid indigestion and sour stomach

-Prevention of heartburn associated with acid indigestion and sour stomach brought on by eating/drinking certain foods and beverages

Precautions

Safety and efficacy of parenteral formulations have not been established in patients younger than 1 year.

Safety and efficacy of oral dissolving tablets have not been established in patients younger than 6 years, and the safety and efficacy of over-the-counter formulations have not been established in patients younger than 12 years.

 

How is Famotidine available?

Famotidine is available in the following dosage forms and strengths:

  • Oral tablet,
  • Intravenous solution,
  • Oral powder for reconstitution,
  • Oral tablet, disintegrating,
  • Oral tablet, chewable,
  • Compounding powder.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Famotidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 9, 2018 | Last Modified: August 9, 2018

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